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The map label for this gene is hisI [H]

Identifier: 157369852

GI number: 157369852

Start: 1764347

End: 1764961

Strand: Reverse

Name: hisI [H]

Synonym: Spro_1609

Alternate gene names: 157369852

Gene position: 1764961-1764347 (Counterclockwise)

Preceding gene: 157369853

Following gene: 157369850

Centisome position: 32.39

GC content: 55.12

Gene sequence:

>615_bases
GTGTTAACAGAACAACAAAGAAACCTGCTGGACTGGGAAAAAACTGACCACCTGCTACCGGTAATCGTCCAGCATGCCGT
ATCCGGCGAAGTGCTGATGCTCGGCTATATGAATCAGGAAGCGCTGGCCGTGACCGAACAGAGCGGCAAGGTCACCTTTT
TCTCACGCACCAAACAGCGCCTGTGGACCAAGGGCGAAAGCTCTGGCCACTTCCTTAACGTAGTCAGCATTACCCCGGAT
TGCGACAACGACACGCTGTTGATTCTGGCCAATCCAATCGGCCCCACCTGCCACCTGGGTAACACCAGTTGCTTCCACCC
GGCCAGCAGCGATTGGGGTTTTCTGTATCAGCTGGAGCAACTGCTGGCAGAACGTAAAAACGCCAGCCCCGATAGCTCTT
ATACCGCCAGCCTGTACGCCAGCGGCACCAAGCGTATCGCGCAGAAAGTCGGGGAAGAAGGCGTGGAGACCGCACTGGCC
GCTACGGTGAATGACCGCGAAGAATTGACCAACGAAGCTTCTGATCTGATTTATCACCTGTTGGTGTTGCTGCAGGATCA
GGATTTGGACTTGAGCAAGGTGATTGGCCGGTTGCGCGAACGGCACCAGAAATAA

Upstream 100 bases:

>100_bases
ATGTCGATGGCGCACTGGCCGCTTCGGTGTTCCACAAACAAATCATTAATATCGGTGACCTGAAAAGGTTCTTGTCCGAA
CAAGGTGTGGAGATCCGCCT

Downstream 100 bases:

>100_bases
CCCTGTTTTTCAGGCAAAAAAAAGCCGCCGGGCGTTAACCTCGGCGGCTTTTTTATGCTTCAAACGTCGGGATTATTCCA
TCCATTCGGTATGGAACACG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MLTEQQRNLLDWEKTDHLLPVIVQHAVSGEVLMLGYMNQEALAVTEQSGKVTFFSRTKQRLWTKGESSGHFLNVVSITPD
CDNDTLLILANPIGPTCHLGNTSCFHPASSDWGFLYQLEQLLAERKNASPDSSYTASLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLIYHLLVLLQDQDLDLSKVIGRLRERHQK

Sequences:

>Translated_204_residues
MLTEQQRNLLDWEKTDHLLPVIVQHAVSGEVLMLGYMNQEALAVTEQSGKVTFFSRTKQRLWTKGESSGHFLNVVSITPD
CDNDTLLILANPIGPTCHLGNTSCFHPASSDWGFLYQLEQLLAERKNASPDSSYTASLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLIYHLLVLLQDQDLDLSKVIGRLRERHQK
>Mature_204_residues
MLTEQQRNLLDWEKTDHLLPVIVQHAVSGEVLMLGYMNQEALAVTEQSGKVTFFSRTKQRLWTKGESSGHFLNVVSITPD
CDNDTLLILANPIGPTCHLGNTSCFHPASSDWGFLYQLEQLLAERKNASPDSSYTASLYASGTKRIAQKVGEEGVETALA
ATVNDREELTNEASDLIYHLLVLLQDQDLDLSKVIGRLRERHQK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=81.7733990147783, Blast_Score=340, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319819, Length=205, Percent_Identity=30.7317073170732, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22768; Mature: 22768

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEQQRNLLDWEKTDHLLPVIVQHAVSGEVLMLGYMNQEALAVTEQSGKVTFFSRTKQR
CCCCCHHCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVSITPDCDNDTLLILANPIGPTCHLGNTSCFHPASSDWGFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHH
LLAERKNASPDSSYTASLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLIYHL
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDLSKVIGRLRERHQK
HHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTEQQRNLLDWEKTDHLLPVIVQHAVSGEVLMLGYMNQEALAVTEQSGKVTFFSRTKQR
CCCCCHHCCCCHHHCCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEHHHHHHH
LWTKGESSGHFLNVVSITPDCDNDTLLILANPIGPTCHLGNTSCFHPASSDWGFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHH
LLAERKNASPDSSYTASLYASGTKRIAQKVGEEGVETALAATVNDREELTNEASDLIYHL
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LVLLQDQDLDLSKVIGRLRERHQK
HHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]