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The map label for this gene is tesB [H]

Identifier: 157369354

GI number: 157369354

Start: 1223721

End: 1224584

Strand: Reverse

Name: tesB [H]

Synonym: Spro_1111

Alternate gene names: 157369354

Gene position: 1224584-1223721 (Counterclockwise)

Preceding gene: 157369356

Following gene: 157369348

Centisome position: 22.47

GC content: 58.45

Gene sequence:

>864_bases
ATGAGCCAGGCACTGCAAAACCTCCTCGATCTGCTGGATCTGGAGAAAATTGAAGAAGGGCTGTTCCGCGGCCAAAGTGA
AGATCTGGGATTACGCCAGGTCTTCGGCGGCCAGGTGGTGGGTCAGGCGCTGTATGCCGCCAAGCAAACGGTGCCTGCCG
AGCGCAGCGTCCACTCGTTCCACAGCTATTTCCTGCGTCCGGGCGACAGCAGTAAGCCAATCATTTATGACGTGGAAATT
CTGCGCGATGGCAACAGCTTCAGCGCCCGTCGCGTCAGCGCCATTCAGCACGGTAAACCGATTTTCTACATGACCGCCTC
CTTCCAAAGTCCGGAAGAAGGCTTTGAACACCAGAACACCATGCCGGACGTGCCGCCGCCAGAAGGGCTGATGTCTGAGT
CAGACATTGCCCAAAAACTGTCGCATATGCTGCCGGACAAGGTGCGTGAGAAGTTTATCGGCCAGAAACCGATTGAGATG
CGTCCGGTCAAATTCCACAATCCGCTGAAAGGCAGTGTGGAAGAACCGCACCGCTACGTATGGTTCCGCGCCAACGGCAC
CATGCCGGACGATCTGCGCATCCATCAGTACCTGCTGGGTTATGCGTCTGACTTCAACTTCCTGCCGACGGCGCTGCAGC
CGCACGGCGTCGGTTTCCTGGAGCCGGGCATGCAGGTGGCGACCATCGATCACTCCATGTGGTTCCACCGCCCATTCCGC
ATGGATGACTGGCTGCTGTACGTGGTGGAAAGCACGTCCGCCTCCGGCGCCCGTGGATTTGTACGCGGTCAATTCTATAC
CCGTGACGGCGTATTGGTTGCCACCACGGTACAGGAAGGCGTGATCCGCCAGCGCGAAGCCTGA

Upstream 100 bases:

>100_bases
CATTCAGTCAATTTTCTCTGTGCCATAACGCAATATATTGACGTCTTGCCGTGATATTCCGCACACTGCGCAAAATGATT
ATTAAAAGGGTAGTAACTTT

Downstream 100 bases:

>100_bases
TAAACGCAGGCCAAAAAAAAGGGCGATGGTGACATCGCCCTTTTTGCATCATCATTATTTTTCGAGTTATTTTAGCGCAC
TGCCCTTCTTCAAGGCTTAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSQALQNLLDLLDLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKQTVPAERSVHSFHSYFLRPGDSSKPIIYDVEI
LRDGNSFSARRVSAIQHGKPIFYMTASFQSPEEGFEHQNTMPDVPPPEGLMSESDIAQKLSHMLPDKVREKFIGQKPIEM
RPVKFHNPLKGSVEEPHRYVWFRANGTMPDDLRIHQYLLGYASDFNFLPTALQPHGVGFLEPGMQVATIDHSMWFHRPFR
MDDWLLYVVESTSASGARGFVRGQFYTRDGVLVATTVQEGVIRQREA

Sequences:

>Translated_287_residues
MSQALQNLLDLLDLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKQTVPAERSVHSFHSYFLRPGDSSKPIIYDVEI
LRDGNSFSARRVSAIQHGKPIFYMTASFQSPEEGFEHQNTMPDVPPPEGLMSESDIAQKLSHMLPDKVREKFIGQKPIEM
RPVKFHNPLKGSVEEPHRYVWFRANGTMPDDLRIHQYLLGYASDFNFLPTALQPHGVGFLEPGMQVATIDHSMWFHRPFR
MDDWLLYVVESTSASGARGFVRGQFYTRDGVLVATTVQEGVIRQREA
>Mature_286_residues
SQALQNLLDLLDLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKQTVPAERSVHSFHSYFLRPGDSSKPIIYDVEIL
RDGNSFSARRVSAIQHGKPIFYMTASFQSPEEGFEHQNTMPDVPPPEGLMSESDIAQKLSHMLPDKVREKFIGQKPIEMR
PVKFHNPLKGSVEEPHRYVWFRANGTMPDDLRIHQYLLGYASDFNFLPTALQPHGVGFLEPGMQVATIDHSMWFHRPFRM
DDWLLYVVESTSASGARGFVRGQFYTRDGVLVATTVQEGVIRQREA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=285, Percent_Identity=43.859649122807, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1786657, Length=284, Percent_Identity=79.9295774647887, Blast_Score=469, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=36.1774744027304, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=304, Percent_Identity=38.1578947368421, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17531889, Length=271, Percent_Identity=35.7933579335793, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=272, Percent_Identity=35.6617647058824, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=272, Percent_Identity=35.6617647058824, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=31.5436241610738, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212645202, Length=285, Percent_Identity=32.6315789473684, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322480, Length=332, Percent_Identity=25, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32524; Mature: 32393

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQALQNLLDLLDLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKQTVPAERSVHSF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRPGDSSKPIIYDVEILRDGNSFSARRVSAIQHGKPIFYMTASFQSPEEGFEHQNT
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCC
MPDVPPPEGLMSESDIAQKLSHMLPDKVREKFIGQKPIEMRPVKFHNPLKGSVEEPHRYV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEECCEECCCCCCCCCCCCCEEE
WFRANGTMPDDLRIHQYLLGYASDFNFLPTALQPHGVGFLEPGMQVATIDHSMWFHRPFR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECHHHHCCCCC
MDDWLLYVVESTSASGARGFVRGQFYTRDGVLVATTVQEGVIRQREA
CCCEEEEEEECCCCCCCCCEEECEEEECCCEEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SQALQNLLDLLDLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKQTVPAERSVHSF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRPGDSSKPIIYDVEILRDGNSFSARRVSAIQHGKPIFYMTASFQSPEEGFEHQNT
HHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCC
MPDVPPPEGLMSESDIAQKLSHMLPDKVREKFIGQKPIEMRPVKFHNPLKGSVEEPHRYV
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCEECCEECCCCCCCCCCCCCEEE
WFRANGTMPDDLRIHQYLLGYASDFNFLPTALQPHGVGFLEPGMQVATIDHSMWFHRPFR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECHHHHCCCCC
MDDWLLYVVESTSASGARGFVRGQFYTRDGVLVATTVQEGVIRQREA
CCCEEEEEEECCCCCCCCCEEECEEEECCCEEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]