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The map label for this gene is cysM [H]

Identifier: 157369348

GI number: 157369348

Start: 1216406

End: 1217449

Strand: Reverse

Name: cysM [H]

Synonym: Spro_1105

Alternate gene names: 157369348

Gene position: 1217449-1216406 (Counterclockwise)

Preceding gene: 157369354

Following gene: 157369346

Centisome position: 22.34

GC content: 57.66

Gene sequence:

>1044_bases
ATGATGACAAATTCTTGGGTAAAATATGCTATCGGTGAAATAGAAGCGGATTTTCAACGCTCCGCCGATACTCACCTGAT
CCGCCTGAACCTGCCGGAATTTCCCGGCATCTGCCTGTACCTGAAAGATGAAAGCACTCACCCGACCGGCAGCCTGAAGC
ACCGGCTGGCGCGTTCACTATTTTTGTATGGTCTGTGTAACGGCTGGATCACCGAAAACACCACGATTATCGAGGCCTCC
TCCGGCAGTACCGCGGTATCCGAAGCTTACTTCGCCCGGCTGATTGGCCTGCCGTTTATTGCCGTCATGCCTTCCTGTAC
CGCACGCCGCAAGGTTGAGCAGATCGCGTTCTACGGCGGTCGCTGTCACTTCGTCGACCATGCGGCGCAAATTTACGCCG
TCTCCGAACAGTTGGCGAAAGAGCTGAACGGCCACTATATGGATCAGTTCACCTACGCTGAACGGGCCACCGACTGGCGC
GGCAACAACAACATCGCCGACAGCATCTTCCGCCAGATGGAACGCGAACCTTTCCCGGTACCCAAGCATATCGTAATGAG
TGCCGGTACCGGTGGCACCTCTGCGACCCTGGGCCGCTATATCCGCTATCAGGGGCACGACACCCGCCTGACGGTGGTCG
ATCCGGAAAATTCGGTGTTCTATGATTGCTTCCACCAGCATGACCGCACCCTTATCGGCAGTTGCGGCAGCCGTATCGAG
GGCATTGGCCGCCCACGCGCCGAGCCATCCTTTATTCCGTCGGTGGTCGACAGCATGATCCGCGTGCCGGATGCCGCCAG
CGTCGCCACTATCCACTGGCTGGAAACGGTGCTCGGACGCAAGGTCGGGGCCTCCACCGGCACCAACGTGTGGGGTGCGC
TGCTGTTGGCGAAGCAAATGCGGGAAAACGGCGAGCAGGGTTCGATTGTGACTCTGCTGTGCGACAGCGGTGAGCGCTAC
CTGGACACCTATTACAACCCGGAATGGGTCAGAAACAATATCGGTGATCTGACGCCTTATCTGGCGCAGTTAGCAGATTT
GTAA

Upstream 100 bases:

>100_bases
ATTTTCTCTCATTAGGCGATTAAACAGGAAAAATGGCAATCCTTTTTTCCTCGTGGCAGGCTATATTATGCAACAAACAA
GCCCCCTATTCTGAGGCCAG

Downstream 100 bases:

>100_bases
TCAGCCGGTTCAGACGAAAAAAAACCGGGTAAGTCATACCCGGCTGGCTGCCAATAAAGCCTCATAATTCGGGGGAATAG
GTGAGGTAAGGTGAACGCAG

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MMTNSWVKYAIGEIEADFQRSADTHLIRLNLPEFPGICLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITENTTIIEAS
SGSTAVSEAYFARLIGLPFIAVMPSCTARRKVEQIAFYGGRCHFVDHAAQIYAVSEQLAKELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMEREPFPVPKHIVMSAGTGGTSATLGRYIRYQGHDTRLTVVDPENSVFYDCFHQHDRTLIGSCGSRIE
GIGRPRAEPSFIPSVVDSMIRVPDAASVATIHWLETVLGRKVGASTGTNVWGALLLAKQMRENGEQGSIVTLLCDSGERY
LDTYYNPEWVRNNIGDLTPYLAQLADL

Sequences:

>Translated_347_residues
MMTNSWVKYAIGEIEADFQRSADTHLIRLNLPEFPGICLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITENTTIIEAS
SGSTAVSEAYFARLIGLPFIAVMPSCTARRKVEQIAFYGGRCHFVDHAAQIYAVSEQLAKELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMEREPFPVPKHIVMSAGTGGTSATLGRYIRYQGHDTRLTVVDPENSVFYDCFHQHDRTLIGSCGSRIE
GIGRPRAEPSFIPSVVDSMIRVPDAASVATIHWLETVLGRKVGASTGTNVWGALLLAKQMRENGEQGSIVTLLCDSGERY
LDTYYNPEWVRNNIGDLTPYLAQLADL
>Mature_347_residues
MMTNSWVKYAIGEIEADFQRSADTHLIRLNLPEFPGICLYLKDESTHPTGSLKHRLARSLFLYGLCNGWITENTTIIEAS
SGSTAVSEAYFARLIGLPFIAVMPSCTARRKVEQIAFYGGRCHFVDHAAQIYAVSEQLAKELNGHYMDQFTYAERATDWR
GNNNIADSIFRQMEREPFPVPKHIVMSAGTGGTSATLGRYIRYQGHDTRLTVVDPENSVFYDCFHQHDRTLIGSCGSRIE
GIGRPRAEPSFIPSVVDSMIRVPDAASVATIHWLETVLGRKVGASTGTNVWGALLLAKQMRENGEQGSIVTLLCDSGERY
LDTYYNPEWVRNNIGDLTPYLAQLADL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=330, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI295821200, Length=330, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4557415, Length=330, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=26.6025641025641, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71996324, Length=353, Percent_Identity=32.8611898016997, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17539800, Length=356, Percent_Identity=31.4606741573034, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17539640, Length=366, Percent_Identity=29.2349726775956, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17535051, Length=340, Percent_Identity=26.4705882352941, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI32566674, Length=292, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=25.8899676375405, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115535073, Length=309, Percent_Identity=26.2135922330097, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=26.8072289156627, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38724; Mature: 38724

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTNSWVKYAIGEIEADFQRSADTHLIRLNLPEFPGICLYLKDESTHPTGSLKHRLARSL
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYGLCNGWITENTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSCTARRKVEQIAFYGG
HHHHHHCCEEECCCEEEEECCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCC
RCHFVDHAAQIYAVSEQLAKELNGHYMDQFTYAERATDWRGNNNIADSIFRQMEREPFPV
EEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PKHIVMSAGTGGTSATLGRYIRYQGHDTRLTVVDPENSVFYDCFHQHDRTLIGSCGSRIE
CCCEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEHHHHHHCCCHHHHHHHHHHH
GIGRPRAEPSFIPSVVDSMIRVPDAASVATIHWLETVLGRKVGASTGTNVWGALLLAKQM
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RENGEQGSIVTLLCDSGERYLDTYYNPEWVRNNIGDLTPYLAQLADL
HHCCCCCCEEEEEECCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MMTNSWVKYAIGEIEADFQRSADTHLIRLNLPEFPGICLYLKDESTHPTGSLKHRLARSL
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHH
FLYGLCNGWITENTTIIEASSGSTAVSEAYFARLIGLPFIAVMPSCTARRKVEQIAFYGG
HHHHHHCCEEECCCEEEEECCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCC
RCHFVDHAAQIYAVSEQLAKELNGHYMDQFTYAERATDWRGNNNIADSIFRQMEREPFPV
EEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PKHIVMSAGTGGTSATLGRYIRYQGHDTRLTVVDPENSVFYDCFHQHDRTLIGSCGSRIE
CCCEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEHHHHHHCCCHHHHHHHHHHH
GIGRPRAEPSFIPSVVDSMIRVPDAASVATIHWLETVLGRKVGASTGTNVWGALLLAKQM
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RENGEQGSIVTLLCDSGERYLDTYYNPEWVRNNIGDLTPYLAQLADL
HHCCCCCCEEEEEECCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]