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The map label for this gene is phoR [H]

Identifier: 157369285

GI number: 157369285

Start: 1145370

End: 1146686

Strand: Direct

Name: phoR [H]

Synonym: Spro_1042

Alternate gene names: 157369285

Gene position: 1145370-1146686 (Clockwise)

Preceding gene: 157369284

Following gene: 157369286

Centisome position: 21.02

GC content: 58.69

Gene sequence:

>1317_bases
GTGCTAGAACGTCTATCCTGGAAGAGGCTGGCCCTGGAGCTGGCCCTTTTCTGCTTGCCTGCCTTGTTGCTGGGGCTGAT
TTTCGGTTATCTGCCCTGGTTGCTGCTGGCCTCCGTGCTGGCGGCGCTGGTATGGAATTTCTACAACCAACTCAAACTTT
CCCACTGGCTGTGGGTTGACCGCAGCATGACGCCGCCACCCGGGCGCTGGAGCTGGGAACCGCTGTTTTACGGCCTGTAT
CAGATGCAGCAGCGTAATCGCCGTCGGCGGCGTGAACTGGCGCTGTTGATCAAACGCTTCCGCAGCGGCGCGGAATCGCT
GCCCGATGCGGTGGTGATGACTACCGTTGAAGGCAATATCTTTTGGTGTAACGGTTTGGCGCAGCATCTGCTGGGTTTCC
GCTGGCCGGAAGACAATGGTCAGCACATCCTTAACCTGCTGCGTTACCCGGAGTTCAGCCACTATCTGCAACAGCAGGAG
TTCACCCGGCCGTTGACGCTGCAGTTGAACAATGAGCACTACGTCGAATTCCGCGTGATGCCTTATTCCGAAGGGCAATT
ACTGATGGTGGCGCGTGACGTCACCCAAATGCGCCAGCTGGAAGGCGCGCGACGCAACTTCTTCGCCAACGTCAGCCACG
AGCTGCGTACCCCGCTCACGGTGTTGCAGGGCTACCTGGAGATGATGAGCGACGAAGAGCTGGATGGCTCGCTGCGCGGC
AAAGCGCTGGGCACCATGCAAGAGCAGACCCGGCGTATGGATGGGCTGGTCAAACAGCTGCTGACGCTGTCGCGGATTGA
GGCTGCGCCTAACGTCGAGATGAACGAACGGGTCGATATCCCACTGATGTTGCGAGTGTTGCAACGGGAAGCGCAGTCGT
TGAGCGGCGGCAACCATGAGATTAGCTTCCGGGTGAACGAACAGCTCAAGGTGTTCGGCAACGACGACCAGCTGCGCAGC
GCGGTATCAAACCTGGTGTACAACGCTGTCAATCACACGCCAAAGGGCACCAATATTGAAGTGAGCTGGCAACAGACGCC
CAACGGCGCGCAGTTCCAGGTCAGTGATAATGGGCCGGGCATCGCCGCCGAGCATATTCCGCGCCTGACCGAACGTTTCT
ATCGCGTCGACAAGGCCCGTTCACGCCAGACCGGCGGCAGTGGGCTGGGGCTGGCGATCGTCAAGCATGCGCTCAGCCAC
CATGACGCGCGATTGGAGATCCTCAGTGAGCAGGGGATTGGCACCCGATTCATCTTTACCTTGCCTAACCGGTTGATTGT
TCCCGCAGCTTTGTCAGAGAATGCGGTGAAAAATTAA

Upstream 100 bases:

>100_bases
GTTAGAGACCAGTGGTCATGACAAAATGGTTCAAACCGTTCGGGGCACCGGCTACCGATTCTCAACGCGCTACTGATCGC
GACGCGCTGGAGAATATGCC

Downstream 100 bases:

>100_bases
CGCGCGAGAGGCAGGTATGATCCGAATGACCCGAGGGCTGTTGCTTTGCCTGGCGCTGCTGGTGAGCCGTGGCGCGTTAG
CGCAGCCGGACGGCATGCTG

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLERLSWKRLALELALFCLPALLLGLIFGYLPWLLLASVLAALVWNFYNQLKLSHWLWVDRSMTPPPGRWSWEPLFYGLY
QMQQRNRRRRRELALLIKRFRSGAESLPDAVVMTTVEGNIFWCNGLAQHLLGFRWPEDNGQHILNLLRYPEFSHYLQQQE
FTRPLTLQLNNEHYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMSDEELDGSLRG
KALGTMQEQTRRMDGLVKQLLTLSRIEAAPNVEMNERVDIPLMLRVLQREAQSLSGGNHEISFRVNEQLKVFGNDDQLRS
AVSNLVYNAVNHTPKGTNIEVSWQQTPNGAQFQVSDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEILSEQGIGTRFIFTLPNRLIVPAALSENAVKN

Sequences:

>Translated_438_residues
MLERLSWKRLALELALFCLPALLLGLIFGYLPWLLLASVLAALVWNFYNQLKLSHWLWVDRSMTPPPGRWSWEPLFYGLY
QMQQRNRRRRRELALLIKRFRSGAESLPDAVVMTTVEGNIFWCNGLAQHLLGFRWPEDNGQHILNLLRYPEFSHYLQQQE
FTRPLTLQLNNEHYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMSDEELDGSLRG
KALGTMQEQTRRMDGLVKQLLTLSRIEAAPNVEMNERVDIPLMLRVLQREAQSLSGGNHEISFRVNEQLKVFGNDDQLRS
AVSNLVYNAVNHTPKGTNIEVSWQQTPNGAQFQVSDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEILSEQGIGTRFIFTLPNRLIVPAALSENAVKN
>Mature_438_residues
MLERLSWKRLALELALFCLPALLLGLIFGYLPWLLLASVLAALVWNFYNQLKLSHWLWVDRSMTPPPGRWSWEPLFYGLY
QMQQRNRRRRRELALLIKRFRSGAESLPDAVVMTTVEGNIFWCNGLAQHLLGFRWPEDNGQHILNLLRYPEFSHYLQQQE
FTRPLTLQLNNEHYVEFRVMPYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMSDEELDGSLRG
KALGTMQEQTRRMDGLVKQLLTLSRIEAAPNVEMNERVDIPLMLRVLQREAQSLSGGNHEISFRVNEQLKVFGNDDQLRS
AVSNLVYNAVNHTPKGTNIEVSWQQTPNGAQFQVSDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH
HDARLEILSEQGIGTRFIFTLPNRLIVPAALSENAVKN

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=427, Percent_Identity=73.3021077283372, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=31.3304721030043, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=36.6515837104072, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=31.3304721030043, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789403, Length=214, Percent_Identity=35.0467289719626, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788713, Length=388, Percent_Identity=23.1958762886598, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789808, Length=238, Percent_Identity=31.9327731092437, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=29.5154185022026, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.0833333333333, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789149, Length=256, Percent_Identity=28.515625, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=25.1141552511416, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=26.5151515151515, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788549, Length=351, Percent_Identity=22.5071225071225, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=223, Percent_Identity=30.9417040358744, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=27.3062730627306, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790567, Length=352, Percent_Identity=23.8636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=25.6521739130435, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=25.6637168141593, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50279; Mature: 50279

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKRLALELALFCLPALLLGLIFGYLPWLLLASVLAALVWNFYNQLKLSHWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
RSMTPPPGRWSWEPLFYGLYQMQQRNRRRRRELALLIKRFRSGAESLPDAVVMTTVEGNI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCE
FWCNGLAQHLLGFRWPEDNGQHILNLLRYPEFSHYLQQQEFTRPLTLQLNNEHYVEFRVM
EEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEEEE
PYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMSDEELDGSLRG
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCCCCCCCCC
KALGTMQEQTRRMDGLVKQLLTLSRIEAAPNVEMNERVDIPLMLRVLQREAQSLSGGNHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
ISFRVNEQLKVFGNDDQLRSAVSNLVYNAVNHTPKGTNIEVSWQQTPNGAQFQVSDNGPG
EEEEECCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
IAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDARLEILSEQGIGTRFIFT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEE
LPNRLIVPAALSENAVKN
CCCCEEEECHHCCCCCCC
>Mature Secondary Structure
MLERLSWKRLALELALFCLPALLLGLIFGYLPWLLLASVLAALVWNFYNQLKLSHWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
RSMTPPPGRWSWEPLFYGLYQMQQRNRRRRRELALLIKRFRSGAESLPDAVVMTTVEGNI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCE
FWCNGLAQHLLGFRWPEDNGQHILNLLRYPEFSHYLQQQEFTRPLTLQLNNEHYVEFRVM
EEECHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCEEEEEEEE
PYSEGQLLMVARDVTQMRQLEGARRNFFANVSHELRTPLTVLQGYLEMMSDEELDGSLRG
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCCCCCCCCC
KALGTMQEQTRRMDGLVKQLLTLSRIEAAPNVEMNERVDIPLMLRVLQREAQSLSGGNHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
ISFRVNEQLKVFGNDDQLRSAVSNLVYNAVNHTPKGTNIEVSWQQTPNGAQFQVSDNGPG
EEEEECCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
IAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDARLEILSEQGIGTRFIFT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEE
LPNRLIVPAALSENAVKN
CCCCEEEECHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]