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The map label for this gene is proY [H]

Identifier: 157369048

GI number: 157369048

Start: 896908

End: 898299

Strand: Reverse

Name: proY [H]

Synonym: Spro_0803

Alternate gene names: 157369048

Gene position: 898299-896908 (Counterclockwise)

Preceding gene: 157369049

Following gene: 157369047

Centisome position: 16.49

GC content: 57.76

Gene sequence:

>1392_bases
ATGCATAACGAAACACCACAACTCAGACGCGGATTAAACGCGCGACATATCCGCTTTATGGCACTCGGCTCCGCCATCGG
CACCGGGCTGTTCTATGGCTCCGCCGGGGCGATCCAACTGGCCGGTCCTGCAGTGCTGCTGGCCTATCTGGTGGGCGGCG
CGGCGGTCTTTATGGTGATGCGCGCGCTGGGGGAAATGGCGGTGCATCAGCCGGTTTCCGGTTCGTTCGGTCACTACGCC
AGCCATTATCTTGGCCCGCTGGCCGGTTTCCTCACCGGCTGGACCTATACCTTCGAAATGGTGATTGTCGCCCTGGCGGA
CGTGACCGCCTTCGGCATCTATATGGGGCTGTGGTTCCCGGACGTCGCCCAATGGGTGTGGGTACTCAGCATTATCATGT
TTATCGGTGCGCTCAATCTGTGCAGCGTGAAAGTGTTCGGCGAAATGGAGTTTTGGCTGTCGCTGATCAAGGTTGCTGCC
ATTGTGGCGATGATAGTCGGCGGCGGTGCCGTGATGCTGTTTGGTTTTGGCCAGGCTCAGCACGCCACCGGCATCAGCAA
TCTGTGGGCGCACGGCGGCTTTATGCCTAACGGCATCGGCGGAGTGGTCGCTTCATTGGCGGTGGTGATGTTCGCCTTCG
GCGGCATTGAAATCATCGGCATTACCGCCAGCGAGGCAAAAGACCCCGCGAAGGTACTGCCGAAGGCAATCAATGCCGTA
CCGATCCGCATTCTGCTGTTTTATGTGCTGACGCTGCTGGTACTGATGGCTATCTATCCATGGAACAGCATCGGCCAGAA
CGGCAGCCCCTTTGTTGAGATCTTCAGCAATCTGGGCATCAGCTCGGCTGCCAACGTACTTAACGTGGTGGTGATCACCG
CCGCCATTTCCGCCATTAACAGCGACATCTTCGGCGCAGGCCGCATGATGTACGGCATGGCGCAGGATGGTCAGGCACCG
AAAAGCTTCTCCAAACTGACCTCCAATGGCGTGCCCTGGATGACGGTGTTAGTGATGTCAGTCGCCCTGCTGCTGGGCGT
GGTGCTCAATTACCTGATCCCGAAACAGGTATTTATGATCATCGCTTCCATCGCCACCTTCGCCACCGTCTGGGTATGGC
TGATGATCCTGCTATCGCAGATTGCCATGCGCCGTACGCTGACGCCGCAAGAAGTCAGCAAATTGAGTTTCCCGGTGCCG
TGGTGGCCAGTCGCACCGGCGCTGGCAACAATATTTATGCTGTTCGTTATCGGCCTGCTCGGTTACTTCGAAGACAGCCG
CATTGCCCTGTACGTGGGGCTGGTGTGGGTGGCCTTCCTTACCCTGGCTTACTGGTTGTGGGTACGTAAAAAAGGCGGGG
GTTCACCCGTCACGTCCTCACCACAGTATTAA

Upstream 100 bases:

>100_bases
ATAAAACCTACCACGCAGTTTGTTCTGTCCCACCGGGCGCTATCCGCCCGGTGCGGATAGCGCGTGCCTGTTCTGCCGTA
AAAACTCGACGGGAAGCAAC

Downstream 100 bases:

>100_bases
TCTCATGAGCCCGCCGTTCCCGGGCTCTTCGTCATTAAAGTGGAGTATCACTATGCAAACACGACACAAATTATGGATAC
CGCTGATCGCGCTCGGGCTG

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHNETPQLRRGLNARHIRFMALGSAIGTGLFYGSAGAIQLAGPAVLLAYLVGGAAVFMVMRALGEMAVHQPVSGSFGHYA
SHYLGPLAGFLTGWTYTFEMVIVALADVTAFGIYMGLWFPDVAQWVWVLSIIMFIGALNLCSVKVFGEMEFWLSLIKVAA
IVAMIVGGGAVMLFGFGQAQHATGISNLWAHGGFMPNGIGGVVASLAVVMFAFGGIEIIGITASEAKDPAKVLPKAINAV
PIRILLFYVLTLLVLMAIYPWNSIGQNGSPFVEIFSNLGISSAANVLNVVVITAAISAINSDIFGAGRMMYGMAQDGQAP
KSFSKLTSNGVPWMTVLVMSVALLLGVVLNYLIPKQVFMIIASIATFATVWVWLMILLSQIAMRRTLTPQEVSKLSFPVP
WWPVAPALATIFMLFVIGLLGYFEDSRIALYVGLVWVAFLTLAYWLWVRKKGGGSPVTSSPQY

Sequences:

>Translated_463_residues
MHNETPQLRRGLNARHIRFMALGSAIGTGLFYGSAGAIQLAGPAVLLAYLVGGAAVFMVMRALGEMAVHQPVSGSFGHYA
SHYLGPLAGFLTGWTYTFEMVIVALADVTAFGIYMGLWFPDVAQWVWVLSIIMFIGALNLCSVKVFGEMEFWLSLIKVAA
IVAMIVGGGAVMLFGFGQAQHATGISNLWAHGGFMPNGIGGVVASLAVVMFAFGGIEIIGITASEAKDPAKVLPKAINAV
PIRILLFYVLTLLVLMAIYPWNSIGQNGSPFVEIFSNLGISSAANVLNVVVITAAISAINSDIFGAGRMMYGMAQDGQAP
KSFSKLTSNGVPWMTVLVMSVALLLGVVLNYLIPKQVFMIIASIATFATVWVWLMILLSQIAMRRTLTPQEVSKLSFPVP
WWPVAPALATIFMLFVIGLLGYFEDSRIALYVGLVWVAFLTLAYWLWVRKKGGGSPVTSSPQY
>Mature_463_residues
MHNETPQLRRGLNARHIRFMALGSAIGTGLFYGSAGAIQLAGPAVLLAYLVGGAAVFMVMRALGEMAVHQPVSGSFGHYA
SHYLGPLAGFLTGWTYTFEMVIVALADVTAFGIYMGLWFPDVAQWVWVLSIIMFIGALNLCSVKVFGEMEFWLSLIKVAA
IVAMIVGGGAVMLFGFGQAQHATGISNLWAHGGFMPNGIGGVVASLAVVMFAFGGIEIIGITASEAKDPAKVLPKAINAV
PIRILLFYVLTLLVLMAIYPWNSIGQNGSPFVEIFSNLGISSAANVLNVVVITAAISAINSDIFGAGRMMYGMAQDGQAP
KSFSKLTSNGVPWMTVLVMSVALLLGVVLNYLIPKQVFMIIASIATFATVWVWLMILLSQIAMRRTLTPQEVSKLSFPVP
WWPVAPALATIFMLFVIGLLGYFEDSRIALYVGLVWVAFLTLAYWLWVRKKGGGSPVTSSPQY

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=331, Percent_Identity=26.5861027190332, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI110347453, Length=330, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71999149, Length=377, Percent_Identity=22.8116710875332, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI114326544, Length=431, Percent_Identity=23.8979118329466, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=431, Percent_Identity=23.8979118329466, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI258614005, Length=367, Percent_Identity=23.9782016348774, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI258614003, Length=367, Percent_Identity=23.9782016348774, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258645169, Length=418, Percent_Identity=22.9665071770335, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=445, Percent_Identity=61.7977528089888, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=44.4196428571429, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=443, Percent_Identity=44.4695259593679, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=42.2657952069717, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI48994972, Length=446, Percent_Identity=41.9282511210762, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=37.6086956521739, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=38.9162561576355, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI1789017, Length=402, Percent_Identity=37.5621890547264, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788480, Length=425, Percent_Identity=36, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI87081869, Length=234, Percent_Identity=24.7863247863248, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082023, Length=334, Percent_Identity=23.6526946107784, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=461, Percent_Identity=25.8134490238612, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532491, Length=425, Percent_Identity=21.8823529411765, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=385, Percent_Identity=22.0779220779221, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=32.0541760722348, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=32.4263038548753, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=422, Percent_Identity=34.3601895734597, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=412, Percent_Identity=30.8252427184466, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=413, Percent_Identity=30.7506053268765, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=403, Percent_Identity=31.2655086848635, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=414, Percent_Identity=30.9178743961353, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=27.5184275184275, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=437, Percent_Identity=27.9176201372998, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=399, Percent_Identity=27.5689223057644, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=26.1083743842365, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=26.5, Blast_Score=146, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=26.9521410579345, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=27.1820448877805, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=428, Percent_Identity=26.1682242990654, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=452, Percent_Identity=25.8849557522124, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=393, Percent_Identity=27.9898218829517, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=22.9838709677419, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=26.634382566586, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161077963, Length=342, Percent_Identity=25.7309941520468, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221512776, Length=416, Percent_Identity=22.8365384615385, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24666159, Length=416, Percent_Identity=22.8365384615385, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668806, Length=423, Percent_Identity=24.113475177305, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356285, Length=423, Percent_Identity=24.113475177305, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668802, Length=423, Percent_Identity=24.113475177305, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49749; Mature: 49749

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNETPQLRRGLNARHIRFMALGSAIGTGLFYGSAGAIQLAGPAVLLAYLVGGAAVFMVM
CCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHH
RALGEMAVHQPVSGSFGHYASHYLGPLAGFLTGWTYTFEMVIVALADVTAFGIYMGLWFP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVAQWVWVLSIIMFIGALNLCSVKVFGEMEFWLSLIKVAAIVAMIVGGGAVMLFGFGQAQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
HATGISNLWAHGGFMPNGIGGVVASLAVVMFAFGGIEIIGITASEAKDPAKVLPKAINAV
HHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCHHHHHHHHHHHH
PIRILLFYVLTLLVLMAIYPWNSIGQNGSPFVEIFSNLGISSAANVLNVVVITAAISAIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SDIFGAGRMMYGMAQDGQAPKSFSKLTSNGVPWMTVLVMSVALLLGVVLNYLIPKQVFMI
HHHHCCCHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASIATFATVWVWLMILLSQIAMRRTLTPQEVSKLSFPVPWWPVAPALATIFMLFVIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GYFEDSRIALYVGLVWVAFLTLAYWLWVRKKGGGSPVTSSPQY
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHNETPQLRRGLNARHIRFMALGSAIGTGLFYGSAGAIQLAGPAVLLAYLVGGAAVFMVM
CCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHH
RALGEMAVHQPVSGSFGHYASHYLGPLAGFLTGWTYTFEMVIVALADVTAFGIYMGLWFP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVAQWVWVLSIIMFIGALNLCSVKVFGEMEFWLSLIKVAAIVAMIVGGGAVMLFGFGQAQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
HATGISNLWAHGGFMPNGIGGVVASLAVVMFAFGGIEIIGITASEAKDPAKVLPKAINAV
HHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCHHHHHHHHHHHH
PIRILLFYVLTLLVLMAIYPWNSIGQNGSPFVEIFSNLGISSAANVLNVVVITAAISAIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SDIFGAGRMMYGMAQDGQAPKSFSKLTSNGVPWMTVLVMSVALLLGVVLNYLIPKQVFMI
HHHHCCCHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASIATFATVWVWLMILLSQIAMRRTLTPQEVSKLSFPVPWWPVAPALATIFMLFVIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GYFEDSRIALYVGLVWVAFLTLAYWLWVRKKGGGSPVTSSPQY
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]