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The map label for this gene is apaH

Identifier: 157368967

GI number: 157368967

Start: 799830

End: 800681

Strand: Reverse

Name: apaH

Synonym: Spro_0722

Alternate gene names: 157368967

Gene position: 800681-799830 (Counterclockwise)

Preceding gene: 157368968

Following gene: 157368962

Centisome position: 14.69

GC content: 59.15

Gene sequence:

>852_bases
ATGTCGACATATCTTATCGGCGACGTTCATGGCTGTTTTGATGAACTGAAATCGCTATTGGCCCAGGTGGCTTTCGATCC
TCAGCAAGACCAACTGTGGCTGACCGGCGATCTGGTCGCCCGCGGCCCCGGTTCACTGGATGTATTGCGCTACGTGCGTT
CACTCGGCCCTGCGGTACGCATGGTGTTGGGCAACCACGACCTGCACCTGCTGGCGGTCTACGCCGGTATCAGCCGCAAC
AAGCCCAAAGACCGCATCACCCCGCTGTTGGAAGCCCCGGACGCCGACGAGTTGATCAACTGGCTGCGCCGCCAACCGGT
ATTGCAGGTAGATGAACAACTCAAGCTGGTGATGGCACATGCCGGTATCACGCCGCAGTGGGACATTGAAACCGCGCAAC
TGTGCGCCCGTGAAGTGGAAGCGGTGCTGAGCAGCGACAGCTACCCACTGTTCCTCGATGCCATGTACGGCGATATGCCG
AACAACTGGAGCCCGGAGCTGAGTGGGCTGGCGCGCTTGCGTTTCAGCACCAATGCCCTGACGCGCATGCGTTACTGCTT
CCCGAATGGCCAGCTCGACATGATCTGCAAAGATGCGCCAGGCACCGCGCCTGCACCGCTCAAACCCTGGTTTGAATTGC
CACGATTGGTCGATGCCGATTACACCATTATCTTTGGTCACTGGGCATCACTGGAAGGCAGGGGTACACCGGCAGGCGTT
ATTGGCCTCGATACCGGCTGCTGCTGGGGAGGCGATCTGACCATGCTGCGCTGGGAAGACCAACAGTACTTTACCCAACC
TGCCAATCGCCGGGATTTGCTGGACGGCGTGCACCAACAGGCAGCGTCATAA

Upstream 100 bases:

>100_bases
CCATGGAAGGCCATTACGAAATGGTTGATCATCAGGGTCAGCCGTTCCAGACCGCTATTCCGGTGTTCCGCTTAGCTATC
CCAACGCTGATTCACTAATT

Downstream 100 bases:

>100_bases
TCAAGCCGGGGCGGTCATGCCGCCCCGCTGTTTTCTTCTTAAGCCCCAATCACTCCACCGTCTTCACGCGTAATCATCAA
TACTGACGAGCGCGGACGCG

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSTYLIGDVHGCFDELKSLLAQVAFDPQQDQLWLTGDLVARGPGSLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRN
KPKDRITPLLEAPDADELINWLRRQPVLQVDEQLKLVMAHAGITPQWDIETAQLCAREVEAVLSSDSYPLFLDAMYGDMP
NNWSPELSGLARLRFSTNALTRMRYCFPNGQLDMICKDAPGTAPAPLKPWFELPRLVDADYTIIFGHWASLEGRGTPAGV
IGLDTGCCWGGDLTMLRWEDQQYFTQPANRRDLLDGVHQQAAS

Sequences:

>Translated_283_residues
MSTYLIGDVHGCFDELKSLLAQVAFDPQQDQLWLTGDLVARGPGSLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRN
KPKDRITPLLEAPDADELINWLRRQPVLQVDEQLKLVMAHAGITPQWDIETAQLCAREVEAVLSSDSYPLFLDAMYGDMP
NNWSPELSGLARLRFSTNALTRMRYCFPNGQLDMICKDAPGTAPAPLKPWFELPRLVDADYTIIFGHWASLEGRGTPAGV
IGLDTGCCWGGDLTMLRWEDQQYFTQPANRRDLLDGVHQQAAS
>Mature_282_residues
STYLIGDVHGCFDELKSLLAQVAFDPQQDQLWLTGDLVARGPGSLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRNK
PKDRITPLLEAPDADELINWLRRQPVLQVDEQLKLVMAHAGITPQWDIETAQLCAREVEAVLSSDSYPLFLDAMYGDMPN
NWSPELSGLARLRFSTNALTRMRYCFPNGQLDMICKDAPGTAPAPLKPWFELPRLVDADYTIIFGHWASLEGRGTPAGVI
GLDTGCCWGGDLTMLRWEDQQYFTQPANRRDLLDGVHQQAAS

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=271, Percent_Identity=78.2287822878229, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_SERP5 (A8G9N8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476956.1
- ProteinModelPortal:   A8G9N8
- SMR:   A8G9N8
- STRING:   A8G9N8
- GeneID:   5605110
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0722
- eggNOG:   COG0639
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- BioCyc:   SPRO399741:SPRO_0722-MONOMER
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31534; Mature: 31403

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYLIGDVHGCFDELKSLLAQVAFDPQQDQLWLTGDLVARGPGSLDVLRYVRSLGPAVR
CCCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCHHHHHHHHHHHCHHHH
MVLGNHDLHLLAVYAGISRNKPKDRITPLLEAPDADELINWLRRQPVLQVDEQLKLVMAH
HHHCCCCEEEEEEECCCCCCCCHHHCCHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
AGITPQWDIETAQLCAREVEAVLSSDSYPLFLDAMYGDMPNNWSPELSGLARLRFSTNAL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHHHHHHHEEECHHHH
TRMRYCFPNGQLDMICKDAPGTAPAPLKPWFELPRLVDADYTIIFGHWASLEGRGTPAGV
HHHHEECCCCCEEEEEECCCCCCCCCCCHHHHCHHHCCCCEEEEEEEEECCCCCCCCCEE
IGLDTGCCWGGDLTMLRWEDQQYFTQPANRRDLLDGVHQQAAS
EECCCCCEECCCEEEEEECCHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STYLIGDVHGCFDELKSLLAQVAFDPQQDQLWLTGDLVARGPGSLDVLRYVRSLGPAVR
CCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCHHHHHHHHHHHCHHHH
MVLGNHDLHLLAVYAGISRNKPKDRITPLLEAPDADELINWLRRQPVLQVDEQLKLVMAH
HHHCCCCEEEEEEECCCCCCCCHHHCCHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
AGITPQWDIETAQLCAREVEAVLSSDSYPLFLDAMYGDMPNNWSPELSGLARLRFSTNAL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHHHHHHHEEECHHHH
TRMRYCFPNGQLDMICKDAPGTAPAPLKPWFELPRLVDADYTIIFGHWASLEGRGTPAGV
HHHHEECCCCCEEEEEECCCCCCCCCCCHHHHCHHHCCCCEEEEEEEEECCCCCCCCCEE
IGLDTGCCWGGDLTMLRWEDQQYFTQPANRRDLLDGVHQQAAS
EECCCCCEECCCEEEEEECCHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA