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The map label for this gene is arcA [H]

Identifier: 157368926

GI number: 157368926

Start: 748413

End: 749129

Strand: Reverse

Name: arcA [H]

Synonym: Spro_0681

Alternate gene names: 157368926

Gene position: 749129-748413 (Counterclockwise)

Preceding gene: 157368931

Following gene: 157368924

Centisome position: 13.75

GC content: 54.39

Gene sequence:

>717_bases
ATGCAGACCCCGCACATTCTGATTGTCGAAGACGAGTTAGTCACTCGTAACACCCTGAAGAGCATTTTCGAGGCGGAAGG
CTACGTTGTTCATGAAGCCAATGATGGTGCAGAGATGCACAACATCCTGTCTGAAAATGATATCAATCTGGTTATCATGG
ACATCAATCTGCCAGGCAAAAATGGCCTGCTGCTGGCGCGTGAATTGCGCGAACAGGCCAGCGTTGCGCTGATGTTCCTG
ACCGGCCGTGATAACGAAGTTGACAAGATCCTCGGCCTGGAAATCGGCGCCGATGATTACATCACCAAGCCATTTAATCC
GCGTGAATTGACCATTCGCGCGCGTAACCTGCTGTCACGCACCATGAACCTGGGCAGCGTCGGCGAAGAACGTCGCCTGG
TTGAAAGCTATAAGTTCAACGGTTGGGAGCTGGACATCAACAGCCGCTCACTGATCAGCCCCGCGGGCGAGCAATACAAA
CTGCCACGCAGTGAATTCCGCGCCATGCTGCACTTCTGCGAAAACCCGGGCAAGATCCAATCCCGTGGCGAACTGCTCAA
GAAGATGACCGGCCGTGAGCTGAAGCCGCATGACCGCACCGTGGACGTGACCATCCGTCGCATCCGCAAGCACTTCGAAT
CAACGCCGGACACGCCGGAAATCATCGCTACTATTCACGGTGAAGGTTACCGTTTCTGCGGCGATCTGGAAGAGTAA

Upstream 100 bases:

>100_bases
GTAGAAGGGAACGTGAGCGCTAATCTCTGCCCTCCGCTATGAAAACAAAGACTTCTGTACTTCCTATTTTCTATTTTGTT
GGCAATTTTAGGTAGCATAT

Downstream 100 bases:

>100_bases
GCCCTCCTCCCGCGTTAAAATATTTGGGGTTCCGCAGAACCCCAAATCTTATTTTGCCTCACCCCAGGGGATGATCGGCA
CTGCACTCAGCGCATTCTTC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVHEANDGAEMHNILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGSVGEERRLVESYKFNGWELDINSRSLISPAGEQYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Sequences:

>Translated_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVHEANDGAEMHNILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGSVGEERRLVESYKFNGWELDINSRSLISPAGEQYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
>Mature_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVHEANDGAEMHNILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGSVGEERRLVESYKFNGWELDINSRSLISPAGEQYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=94.5378151260504, Blast_Score=459, Evalue=1e-131,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.0600858369099, Blast_Score=187, Evalue=5e-49,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=34.7639484978541, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.0472103004292, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.4827586206897, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.4893617021277, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=31.8777292576419, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=31.5789473684211, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=33.6283185840708, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.8777292576419, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=29.2035398230088, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=203, Percent_Identity=33.4975369458128, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=29.6137339055794, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=26.8867924528302, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27157; Mature: 27157

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYVVHEANDGAEMHNILSENDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGSVGEERRLVESYKFNGWELDINSRSLISPAGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCH
SRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYVVHEANDGAEMHNILSENDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGSVGEERRLVESYKFNGWELDINSRSLISPAGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCH
SRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]