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The map label for this gene is obgE

Identifier: 157368723

GI number: 157368723

Start: 525813

End: 526985

Strand: Direct

Name: obgE

Synonym: Spro_0476

Alternate gene names: 157368723

Gene position: 525813-526985 (Clockwise)

Preceding gene: 157368722

Following gene: 157368727

Centisome position: 9.65

GC content: 55.41

Gene sequence:

>1173_bases
ATGAAGTTTGTAGATGAAGCAGCGATCTTGGTCGTTGCAGGTGACGGTGGTAATGGTTGCGTCAGCTTCCGTCGCGAAAA
ATATATCCCGAACGGCGGGCCTGATGGCGGTGACGGCGGCGATGGCGGCGACGTCTATCTGTTGGCGGACGAAAACCTCA
ACACGCTGATCGACTACCGCTTTGAGAAATCTTTCCGCGCCGAACGTGGCCAGAATGGTCAGAGCCGTGACTGTACCGGT
AAGCGTGGCAAAGATATTACCATCAAGGTTCCGGTCGGTACTCGCGTGCAGGATCAGGGCACCGGCGAAATCCTCGGCGA
CATGACCCGTCACGAGCAGCGTCTGATGGTGGCGAAGGGCGGTTGGCACGGTTTGGGCAACACCCGTTTTAAATCATCCG
TTAACCGTGCTCCGCGCCAAAAAACGCTGGGCACCGCCGGTGAGGCTCGTGACATCCTGCTGGAGCTGTTGCTGCTGGCG
GATGTGGGTATGCTGGGCCTGCCGAACGCCGGCAAGTCGACCTTTATCCGTGCAGTCTCTGCTGCAAAGCCAAAAGTTGC
CGACTATCCGTTTACCACTCTGGTGCCAAGCCTGGGTGTGGTACGTATGGATCACGAGCAAAGCTTCGTGGTTGCCGATA
TTCCGGGGCTGATCGAAGGTGCCTCCGACGGCGCTGGCCTGGGTATTCGCTTCCTGAAGCATCTGGAGCGCTGCCGCGTG
CTGTTGCACCTGGTGGATATCGCCCCGATCGATGAATCTGATCCGGTAGAAAACGCCAAAGTCATCATCAACGAGTTGAA
TCAGTACAGCGAGAATCTGTCGCAGAAGCCACGCTGGCTGGTTTTCAACAAGATTGATGTGATTGGTGAAGAAGAAGCTG
CCGAACGTGCCAAGGCGATTGCAGAGGGCATGGGCTGGGAAGGTAAGTACTACATGATCTCCGCCGTCAATCGTGAAGGC
GTCAACGCGCTGTGCTGGGATGTGATGAAGTTTATCAATACCCAACCGAAAGCCATGGCAATTGAAGAAAGCGCGCCGGA
GAAAGTCGAGTTCATGTGGGATGATTATCACCGTGAACAGATCGCTGAAGTGGAAGCTGAAGCGGATGACGACTGGGATG
ACGACTGGGATGAAGAGGACGACGAAGGCGTCGAAATCATTTACCAGAAGTAA

Upstream 100 bases:

>100_bases
ATGTTTTCCGCAATTGGTCACCGTTGGTGGCCGCGACGGGCAGAACCCCGCCTGGTTGCTCCTTTGAAGCAGCCCGGTGA
ATGATTTACGGAGACGGTAA

Downstream 100 bases:

>100_bases
TCTTGTGAAGAGAGGGGCTCAGTTAACACTGGCCCTTTTTTTATTTCAGGACGTTTTCCGGGAGCCAGCATTGTGCATTG
AGCCCGCTGGTGTCCTGGCG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLLADENLNTLIDYRFEKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVQDQGTGEILGDMTRHEQRLMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTAGEARDILLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDHEQSFVVADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDIAPIDESDPVENAKVIINELNQYSENLSQKPRWLVFNKIDVIGEEEAAERAKAIAEGMGWEGKYYMISAVNREG
VNALCWDVMKFINTQPKAMAIEESAPEKVEFMWDDYHREQIAEVEAEADDDWDDDWDEEDDEGVEIIYQK

Sequences:

>Translated_390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLLADENLNTLIDYRFEKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVQDQGTGEILGDMTRHEQRLMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTAGEARDILLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDHEQSFVVADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDIAPIDESDPVENAKVIINELNQYSENLSQKPRWLVFNKIDVIGEEEAAERAKAIAEGMGWEGKYYMISAVNREG
VNALCWDVMKFINTQPKAMAIEESAPEKVEFMWDDYHREQIAEVEAEADDDWDDDWDEEDDEGVEIIYQK
>Mature_390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLLADENLNTLIDYRFEKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVQDQGTGEILGDMTRHEQRLMVAKGGWHGLGNTRFKSSVNRAPRQKTLGTAGEARDILLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDHEQSFVVADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDIAPIDESDPVENAKVIINELNQYSENLSQKPRWLVFNKIDVIGEEEAAERAKAIAEGMGWEGKYYMISAVNREG
VNALCWDVMKFINTQPKAMAIEESAPEKVEFMWDDYHREQIAEVEAEADDDWDDDWDEEDDEGVEIIYQK

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=322, Percent_Identity=40.0621118012422, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI111955139, Length=271, Percent_Identity=40.2214022140221, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI111955063, Length=127, Percent_Identity=45.6692913385827, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=34.6456692913386, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=31.8518518518519, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789574, Length=390, Percent_Identity=79.4871794871795, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=33.59375, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=324, Percent_Identity=37.962962962963, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=31.4935064935065, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=35.9375, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=32.2033898305085, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=169, Percent_Identity=37.8698224852071, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=30.952380952381, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129375, Length=285, Percent_Identity=41.0526315789474, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=36.3344051446945, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=33.59375, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=33.59375, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=33.59375, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_SERP5 (A8G8Z4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476712.1
- ProteinModelPortal:   A8G8Z4
- SMR:   A8G8Z4
- STRING:   A8G8Z4
- GeneID:   5607298
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0476
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   YIQADEN
- ProtClustDB:   PRK12298
- BioCyc:   SPRO399741:SPRO_0476-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 43061; Mature: 43061

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLLADENLNTLIDYR
CCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
FEKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVQDQGTGEILGDMTRHEQRLMVAKG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTLGTAGEARDILLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDHEQSFVVADIPGLIEGASDGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLVDIAPIDESDPVENAKVIINELNQYSENLSQKPRWLVFNKIDVIGEEEAAERAKAI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
AEGMGWEGKYYMISAVNREGVNALCWDVMKFINTQPKAMAIEESAPEKVEFMWDDYHREQ
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEHHHHHHHHHH
IAEVEAEADDDWDDDWDEEDDEGVEIIYQK
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLLADENLNTLIDYR
CCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
FEKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVQDQGTGEILGDMTRHEQRLMVAKG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTLGTAGEARDILLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLVPSLGVVRMDHEQSFVVADIPGLIEGASDGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLVDIAPIDESDPVENAKVIINELNQYSENLSQKPRWLVFNKIDVIGEEEAAERAKAI
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
AEGMGWEGKYYMISAVNREGVNALCWDVMKFINTQPKAMAIEESAPEKVEFMWDDYHREQ
HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEHHHHHHHHHH
IAEVEAEADDDWDDDWDEEDDEGVEIIYQK
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA