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The map label for this gene is hflC [H]

Identifier: 157368681

GI number: 157368681

Start: 486185

End: 487192

Strand: Direct

Name: hflC [H]

Synonym: Spro_0434

Alternate gene names: 157368681

Gene position: 486185-487192 (Clockwise)

Preceding gene: 157368680

Following gene: 157368682

Centisome position: 8.92

GC content: 54.76

Gene sequence:

>1008_bases
ATGCGTAAGTCTTTTATAGTAATTATCCTCGCGGTGCTGGTGGCGTTGTATGCATCCTTGTTCGTGGTTCAGGAAGGTCA
GCGCGGCATCGTGCTGCGTTTCGGCAAGGTACTGCGTGACAGCGACAACAAACCGCTGGTCTATGCGCCGGGCCTGCACT
TCAAGATCCCGTTCATTGAAACAGTGAAAACGCTGGATGCACGTATCCAGACCATGGACAACCAGGCTGACCGCTTTGTT
ACCAGCGAGAAGAAAGACCTGATCGTCGACTCATACCTGAAATGGCGTATCAGCGATTTCAGCCGTTACTATCTGGCAAC
CGGCGGCGGTGATGTTTCACAGGCCGAAGTGTTGCTGAAACGTAAGTTCAGTGACCGTCTGCGTTCCGAAATTGGTCGTC
TGGATGTTAAAGACATCGTGACCGACTCGCGCGGTAAACTGATGTCCGACGTGCGTGACGCGCTGAACACCGGTACCGTC
GGTGATGACCAGGAAGTGGCGACCACCGAAGCCGATGACGCTATTGCTTCTGCAGCGGCGCGTGTTGAAAAGGAAACCAC
CGGCAAACTGCCGAAGGTTAACCCGAACAGCATGGCGGCGTTGGGTATCGAAGTGATCGACGTGCGTATCAAGCAGATCA
ACCTGCCGGCAGAAGTGTCAGATGCAATCTACCAGCGTATGCGCGCCGAGCGTGAAGCGGTAGCCCGTCGTCACCGTTCA
CAGGGTCAGGAAGAGGCTGAGAAGCTGCGCGCTACCGCAGACTACGAAGTGACTCGTACCCTGGCGGAAGCCGAACGTAC
AGCGCGTATCACCCGTGGTGAAGGTAATGCCGAAGCGGCCAAACTGTTTGCTAACGCATTCAGTCAGGATCCGGACTTCT
ATGCCTTTATCCGTAGCCTGCGTGCTTATGAAACCAGCTTCAGCAGCAATAACCAGGACGTGATGGTACTGAGCCCGGAC
AGCGATTTCTTCCGCTACATGAAGTCGCCTGATTCCGTACGCAAGTAA

Upstream 100 bases:

>100_bases
CAGCTCCAGCAGCCAGCGCACCAGTAACGGCACGGTCATGGACCAGCGCCGGGCGAATGCGCAGCGTGACGACACCACTC
GCGTAGGGAGAGAATAATCA

Downstream 100 bases:

>100_bases
CCGCGACAGGTTAATGATCGAGGGCCCGTTTAAACGCGGGCCCTTTCTTTTTGGGAGACATTGATGAATTCAACGATCTG
GCTGGCGCTTGGGCTGGTTT

Product: FtsH protease regulator HflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRKSFIVIILAVLVALYASLFVVQEGQRGIVLRFGKVLRDSDNKPLVYAPGLHFKIPFIETVKTLDARIQTMDNQADRFV
TSEKKDLIVDSYLKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGKLMSDVRDALNTGTV
GDDQEVATTEADDAIASAAARVEKETTGKLPKVNPNSMAALGIEVIDVRIKQINLPAEVSDAIYQRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERTARITRGEGNAEAAKLFANAFSQDPDFYAFIRSLRAYETSFSSNNQDVMVLSPD
SDFFRYMKSPDSVRK

Sequences:

>Translated_335_residues
MRKSFIVIILAVLVALYASLFVVQEGQRGIVLRFGKVLRDSDNKPLVYAPGLHFKIPFIETVKTLDARIQTMDNQADRFV
TSEKKDLIVDSYLKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGKLMSDVRDALNTGTV
GDDQEVATTEADDAIASAAARVEKETTGKLPKVNPNSMAALGIEVIDVRIKQINLPAEVSDAIYQRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERTARITRGEGNAEAAKLFANAFSQDPDFYAFIRSLRAYETSFSSNNQDVMVLSPD
SDFFRYMKSPDSVRK
>Mature_335_residues
MRKSFIVIILAVLVALYASLFVVQEGQRGIVLRFGKVLRDSDNKPLVYAPGLHFKIPFIETVKTLDARIQTMDNQADRFV
TSEKKDLIVDSYLKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGKLMSDVRDALNTGTV
GDDQEVATTEADDAIASAAARVEKETTGKLPKVNPNSMAALGIEVIDVRIKQINLPAEVSDAIYQRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERTARITRGEGNAEAAKLFANAFSQDPDFYAFIRSLRAYETSFSSNNQDVMVLSPD
SDFFRYMKSPDSVRK

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=332, Percent_Identity=83.7349397590361, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 37594; Mature: 37594

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSFIVIILAVLVALYASLFVVQEGQRGIVLRFGKVLRDSDNKPLVYAPGLHFKIPFIE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCEEECCHHH
TVKTLDARIQTMDNQADRFVTSEKKDLIVDSYLKWRISDFSRYYLATGGGDVSQAEVLLK
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGKLMSDVRDALNTGTVGDDQEVATTEADDAIASAAA
HHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHH
RVEKETTGKLPKVNPNSMAALGIEVIDVRIKQINLPAEVSDAIYQRMRAEREAVARRHRS
HHHHHHCCCCCCCCCCCHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTRTLAEAERTARITRGEGNAEAAKLFANAFSQDPDFYAFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RAYETSFSSNNQDVMVLSPDSDFFRYMKSPDSVRK
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCHHCCC
>Mature Secondary Structure
MRKSFIVIILAVLVALYASLFVVQEGQRGIVLRFGKVLRDSDNKPLVYAPGLHFKIPFIE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCEEECCHHH
TVKTLDARIQTMDNQADRFVTSEKKDLIVDSYLKWRISDFSRYYLATGGGDVSQAEVLLK
HHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGKLMSDVRDALNTGTVGDDQEVATTEADDAIASAAA
HHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHH
RVEKETTGKLPKVNPNSMAALGIEVIDVRIKQINLPAEVSDAIYQRMRAEREAVARRHRS
HHHHHHCCCCCCCCCCCHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTRTLAEAERTARITRGEGNAEAAKLFANAFSQDPDFYAFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RAYETSFSSNNQDVMVLSPDSDFFRYMKSPDSVRK
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]