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The map label for this gene is hflK [H]

Identifier: 157368680

GI number: 157368680

Start: 484922

End: 486181

Strand: Direct

Name: hflK [H]

Synonym: Spro_0433

Alternate gene names: 157368680

Gene position: 484922-486181 (Clockwise)

Preceding gene: 157368679

Following gene: 157368681

Centisome position: 8.9

GC content: 57.86

Gene sequence:

>1260_bases
ATGGCGTGGAATCAGCCCGGTAATAACGGACAGGACCGCGACCCGTGGGGGAGCAGCAATAACAATGGCGGCAACTCTGG
CGGTAATAACAAAGGCGGTCGCGATCAAGGGCCACCTGATTTGGACGATATCTTCCGCAAGCTGAGCAAGAAACTGAGCG
GCTTGGGCGGGGGCAAAGGCTCCAACAACAATAACGACGGCGGTACTGGCACTTCGGGGCCGGGCTTTAGCGGTCGTATT
ATCGGTATCGCTGCGGTTGCGGTGGTGGTGATTTGGGCCGCCAGCGGTTTCTACACCATCAAAGAAGCCGAGCGCGGTGT
CGTGACTCGTTTCGGCAAGTTCAGCCACCTGGTGCAGCCGGGTCTGAACTGGAAGCCGACCTTCATCGATGAAGTGCGTC
CGGTCAACGTAGAGTCGGTGCGTGAACTGGCCGCTTCTGGCGTGATGCTGACCTCCGATGAGAACGTGGTGCGCGTAGAA
ATGAACGTGCAGTACCGCGTGACCAATCCGGAAGCCTATCTGTTCAGCGTGACCAACGCCGACGATAGCCTGAGCCAGGC
TACTGACAGCGCCCTGCGTGGCGTTATCGGCAAGTACACCATGGACAAGATCCTGACCGAAGGCCGTACTATCGTGCGTA
GCGATACCCAACGCGTACTGGAAGAGACTATTCGTCCGTACAACATGGGCATCACGCTGCTGGACGTCAACTTCCAGGCC
GCTCGTCCGCCGGAAGAGGTGAAAGCCGCATTTGATGATGCGATTGCCGCACGTGAGAACGAGCAGCAGTACATCCGTGA
GGCAGAAGCTTACGCCAACGAAGTTCAGCCACGCGCTAATGGCCAGGCACAGCGTCTGTTGGAAGATGCCAAAGCCTATA
AAGACCGTACCGTCCTGGAAGCACAGGGTGAGGTTGCGGGCTTTGCCAAGCTGTTGCCGGAATACAAGTCTGCACCGCAA
ATCACCCGCGAGCGTCTGTATATCGAAACCATGGAAAAAGTCCTGAGCCACACCCGTAAAGTGTTGGTGAATGACAAAGG
CAACAATCTTATGGTGTTACCGCTGGATCAAATGCTGCGTGGCCAAACCGGCGCGGCGGCTGAAGGCAGTAAAGACACCA
GCCTGATTCGTCTCAACCCCGCTCCGTCTGCCAACAGCGGCGCCAGCTCCAGCAGCCAGCGCACCAGTAACGGCACGGTC
ATGGACCAGCGCCGGGCGAATGCGCAGCGTGACGACACCACTCGCGTAGGGAGAGAATAA

Upstream 100 bases:

>100_bases
AGGAACTGGATCTGATTAACTTTATAGTATGATCATATCCTGTTACATTTGAGCTTCGCGTAAGCCTGAAGTACCCAATC
ACAGAATATGGAGCTAAAAC

Downstream 100 bases:

>100_bases
TCAATGCGTAAGTCTTTTATAGTAATTATCCTCGCGGTGCTGGTGGCGTTGTATGCATCCTTGTTCGTGGTTCAGGAAGG
TCAGCGCGGCATCGTGCTGC

Product: FtsH protease regulator HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNKGGRDQGPPDLDDIFRKLSKKLSGLGGGKGSNNNNDGGTGTSGPGFSGRI
IGIAAVAVVVIWAASGFYTIKEAERGVVTRFGKFSHLVQPGLNWKPTFIDEVRPVNVESVRELAASGVMLTSDENVVRVE
MNVQYRVTNPEAYLFSVTNADDSLSQATDSALRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYNMGITLLDVNFQA
ARPPEEVKAAFDDAIAARENEQQYIREAEAYANEVQPRANGQAQRLLEDAKAYKDRTVLEAQGEVAGFAKLLPEYKSAPQ
ITRERLYIETMEKVLSHTRKVLVNDKGNNLMVLPLDQMLRGQTGAAAEGSKDTSLIRLNPAPSANSGASSSSQRTSNGTV
MDQRRANAQRDDTTRVGRE

Sequences:

>Translated_419_residues
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNKGGRDQGPPDLDDIFRKLSKKLSGLGGGKGSNNNNDGGTGTSGPGFSGRI
IGIAAVAVVVIWAASGFYTIKEAERGVVTRFGKFSHLVQPGLNWKPTFIDEVRPVNVESVRELAASGVMLTSDENVVRVE
MNVQYRVTNPEAYLFSVTNADDSLSQATDSALRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYNMGITLLDVNFQA
ARPPEEVKAAFDDAIAARENEQQYIREAEAYANEVQPRANGQAQRLLEDAKAYKDRTVLEAQGEVAGFAKLLPEYKSAPQ
ITRERLYIETMEKVLSHTRKVLVNDKGNNLMVLPLDQMLRGQTGAAAEGSKDTSLIRLNPAPSANSGASSSSQRTSNGTV
MDQRRANAQRDDTTRVGRE
>Mature_418_residues
AWNQPGNNGQDRDPWGSSNNNGGNSGGNNKGGRDQGPPDLDDIFRKLSKKLSGLGGGKGSNNNNDGGTGTSGPGFSGRII
GIAAVAVVVIWAASGFYTIKEAERGVVTRFGKFSHLVQPGLNWKPTFIDEVRPVNVESVRELAASGVMLTSDENVVRVEM
NVQYRVTNPEAYLFSVTNADDSLSQATDSALRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYNMGITLLDVNFQAA
RPPEEVKAAFDDAIAARENEQQYIREAEAYANEVQPRANGQAQRLLEDAKAYKDRTVLEAQGEVAGFAKLLPEYKSAPQI
TRERLYIETMEKVLSHTRKVLVNDKGNNLMVLPLDQMLRGQTGAAAEGSKDTSLIRLNPAPSANSGASSSSQRTSNGTVM
DQRRANAQRDDTTRVGRE

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=418, Percent_Identity=78.7081339712919, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786697, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 45508; Mature: 45377

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNQPGNNGQDRDPWGSSNNNGGNSGGNNKGGRDQGPPDLDDIFRKLSKKLSGLGGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SNNNNDGGTGTSGPGFSGRIIGIAAVAVVVIWAASGFYTIKEAERGVVTRFGKFSHLVQP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHCC
GLNWKPTFIDEVRPVNVESVRELAASGVMLTSDENVVRVEMNVQYRVTNPEAYLFSVTNA
CCCCCCCHHHCCCCCCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCEEEEEEECC
DDSLSQATDSALRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYNMGITLLDVNFQA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCEEEEEECCCC
ARPPEEVKAAFDDAIAARENEQQYIREAEAYANEVQPRANGQAQRLLEDAKAYKDRTVLE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHEE
AQGEVAGFAKLLPEYKSAPQITRERLYIETMEKVLSHTRKVLVNDKGNNLMVLPLDQMLR
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHC
GQTGAAAEGSKDTSLIRLNPAPSANSGASSSSQRTSNGTVMDQRRANAQRDDTTRVGRE
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure 
AWNQPGNNGQDRDPWGSSNNNGGNSGGNNKGGRDQGPPDLDDIFRKLSKKLSGLGGGKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
SNNNNDGGTGTSGPGFSGRIIGIAAVAVVVIWAASGFYTIKEAERGVVTRFGKFSHLVQP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHCC
GLNWKPTFIDEVRPVNVESVRELAASGVMLTSDENVVRVEMNVQYRVTNPEAYLFSVTNA
CCCCCCCHHHCCCCCCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCEEEEEEECC
DDSLSQATDSALRGVIGKYTMDKILTEGRTIVRSDTQRVLEETIRPYNMGITLLDVNFQA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCEEEEEECCCC
ARPPEEVKAAFDDAIAARENEQQYIREAEAYANEVQPRANGQAQRLLEDAKAYKDRTVLE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHEE
AQGEVAGFAKLLPEYKSAPQITRERLYIETMEKVLSHTRKVLVNDKGNNLMVLPLDQMLR
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEHHHHHC
GQTGAAAEGSKDTSLIRLNPAPSANSGASSSSQRTSNGTVMDQRRANAQRDDTTRVGRE
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]