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The map label for this gene is ugd [H]

Identifier: 157154758

GI number: 157154758

Start: 2281109

End: 2282275

Strand: Reverse

Name: ugd [H]

Synonym: EcE24377A_2319

Alternate gene names: 157154758

Gene position: 2282275-2281109 (Counterclockwise)

Preceding gene: 157157026

Following gene: 157156091

Centisome position: 45.83

GC content: 43.19

Gene sequence:

>1167_bases
ATGAAAATCACCATTTCCGGTACTGGCTATGTAGGCTTGTCAAACGGGCTTCTAATCGCACAAAATCATGAGGTTGTGGC
ATTAGATATTTTACCGTCACGCGTTGCTATGCTGAATGATCGGATATCTCCTATTGTTGATAAGGAAATTCAGCAGTTTT
TGCAAGCAGATAAAATACACTTTAATGCCACATTAGATAAAAATGAAGCCTACCGGGATGCTGATTATGTCATCATCGCC
ACTCCAACCGACTATGATCCTAAAACTAATTATTTCAATACATCCAGTGTAGAATCAGTAATTAAAGACGTAGTTGAGAT
AAATCCTTATGCGGTTATGGTCGTCAAATCAACGGTTCCCGTTGGTTTTACCGCAGCGATGCATAAGAAATATCGTACTG
AAAATATTATTTTCTCTCCGGAATTTCTCCGTGAAGGTAAAGCCCTTTACGATAATCTCCATCCGTCACGTATTGTCATT
GGTGAGCGTTCAGAACGCGCAGAACGTTTTGCTGCGTTGTTACAGGAAGGCGCGATTAAGCAAAATATCCCGACCCTGTT
TACCGATTCAACCGAAGCAGAAGCGATCAAACTGTTTGCTAATACCTATCTGGCGATGCGCGTAGCATACTTTAATGAAC
TGGATAGCTATGCAGAAAGTTTAGGGCTGAATACTCGCCAGATTATCGAAGGCGTTTGTCTCGATCCGCGTATTGGCAAC
CATTACAACAATCCGTCGTTTGGTTATGGTGGTTATTGTCTGCCGAAAGATACCAAGCAGTTACTGGCGAACTACCAGTC
TGTGCCGAATAACCTGATTTCGGCAATTGTCGATGCAAACCGTACACGTAAAGATTTTATTGCCGATGCCATTTTGTCAC
GCAAGCCGCAAGTAGTGGGTATTTATCGTCTGATTATGAAGAGCGGATCAGATAACTTCCGTGCGTCTTCCATTCAGGGG
ATTATGAAACGTATCAAGGCGAAAGGCGTTGAAGTGATCATCTACGAACCGGTGATGAAAGAAGATTCATTCTTCAACTC
TCGGCTGGAACGTGATCTCGCCACTTTCAAACAACAAGCCGACGTCATTATTTCCAACCGTATGGCAGAAGAGCTTAAGG
ATGTGGCAGACAAAGTCTACACCCGCGATCTTTTTGGCAGCGACTAA

Upstream 100 bases:

>100_bases
TTGCGTTGACCATCTGATAACGTAGCGTTAAAACTTTTAGCTCTTATCAGGATGCTAAAAACATCATGATTCATAGTTAA
GTTAATTCTGAGAGCATGAA

Downstream 100 bases:

>100_bases
CATCATGTTATCAGGGCGATTTTCGCCCTGATTCTCTTATGTTCCCTTTGTAATAATTCATTATTTTTATCATTTATCCT
ATAGCATTCATGGCGATTAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQADKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVVKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD

Sequences:

>Translated_388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQADKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVVKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD
>Mature_388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQADKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVVKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=368, Percent_Identity=26.3586956521739, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI296040438, Length=263, Percent_Identity=25.8555133079848, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI296040443, Length=217, Percent_Identity=26.7281105990783, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=98.9690721649485, Blast_Score=791, Evalue=0.0,
Organism=Escherichia coli, GI48994968, Length=376, Percent_Identity=23.6702127659574, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=400, Percent_Identity=26, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136908, Length=367, Percent_Identity=25.8855585831063, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43611; Mature: 43611

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQADKIH
CEEEEECCCEEEECCCEEEECCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVVKSTVP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
VGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK
CCHHHHHHHHHCCCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DVIISNRMAEELKDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQADKIH
CEEEEECCCEEEECCCEEEECCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVVKSTVP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
VGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK
CCHHHHHHHHHCCCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDPRIGN
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DVIISNRMAEELKDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]