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The map label for this gene is sugE

Identifier: 157163616

GI number: 157163616

Start: 4402171

End: 4402488

Strand: Direct

Name: sugE

Synonym: EcHS_A4392

Alternate gene names: 157163616

Gene position: 4402171-4402488 (Clockwise)

Preceding gene: 157163615

Following gene: 157163623

Centisome position: 94.8

GC content: 53.46

Gene sequence:

>318_bases
ATGTCCTGGATTATCTTAGTTATTGCTGGTCTGCTGGAAGTGGTATGGGCCGTTGGCCTGAAATATACCCACGGCTTTAG
TCGTTTGACGCCAAGTGTTATTACTGTGACGGCGATGATAGTCAGTATGGCGCTACTTGCCTGGGCGATGAAATCGTTAC
CGGTAGGGACGGCTTATGCCGTGTGGACGGGTATTGGCGCAGTCGGCGCGGCCATCACCGGCATTGTGCTGCTCGGTGAG
TCCGCTAACCCGATGCGCCTGGCGAGTCTGGCGTTAATCGTATTGGGGATTATTGGTCTGAAACTCAGCACTCACTAA

Upstream 100 bases:

>100_bases
CCTGCCACCTGGCAAAATATCCGTTCAACCATCAGCTTTGCAGGACGACCTGCAAACGCCTCTTTTCACCGGGGACGGCC
CCAATTCTCCGGAGCCTGAT

Downstream 100 bases:

>100_bases
CTACCGGGCTGCTGTACCCAAATAAACTTACTGACATCAAACCCTTCCCGGGTCGCGACTGCCAGCATCTCCTGTTTCAC
TTCGTCAGAAATGGTTGGCG

Product: quaternary ammonium compound-resistance protein SugE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE
SANPMRLASLALIVLGIIGLKLSTH

Sequences:

>Translated_105_residues
MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGE
SANPMRLASLALIVLGIIGLKLSTH
>Mature_104_residues
SWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGES
ANPMRLASLALIVLGIIGLKLSTH

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily

Homologues:

Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=100, Blast_Score=196, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUGE_ECO57 (Q8XDQ5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A86111
- PIR:   A98270
- RefSeq:   NP_290783.1
- RefSeq:   NP_313156.1
- ProteinModelPortal:   Q8XDQ5
- EnsemblBacteria:   EBESCT00000026548
- EnsemblBacteria:   EBESCT00000057716
- GeneID:   913177
- GeneID:   959973
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5755
- KEGG:   ecs:ECs5129
- GeneTree:   EBGT00050000009344
- HOGENOM:   HBG740972
- OMA:   DMSWIIL
- ProtClustDB:   CLSK512873
- BioCyc:   ECOL83334:ECS5129-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 10900; Mature: 10769

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19478594)-; HASH(0x18b02448)-; HASH(0x40509f0c)-; HASH(0x18a50c68)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796