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The map label for this gene is glpG [H]

Identifier: 157162901

GI number: 157162901

Start: 3604892

End: 3605722

Strand: Reverse

Name: glpG [H]

Synonym: EcHS_A3621

Alternate gene names: 157162901

Gene position: 3605722-3604892 (Counterclockwise)

Preceding gene: 157162902

Following gene: 157162900

Centisome position: 77.65

GC content: 54.15

Gene sequence:

>831_bases
ATGTTGATGATTACCTCTTTTGCTAACCCCCGCGTGGCGCAGGCGTTTGTTGATTACATGGCGACGCAGGGTGTTATCCT
CACGATTCAACAACATAACCAAAGCGATGTCTGGCTGGCGGATGAGTCCCAGGCCGAGCGCGTACGGGCGGAGCTGGCGC
GTTTTCTCGAAAACCCGGCAGATCCGCGTTATCTGGCGGCGAGCTGGCAGGCAGGCCATACCGGCAGTGGCCTGCATTAT
CGCCGTTATCCTTTCTTTGCCGCCTTGCGTGAACGCGCAGGTCCGGTAACCTGGGTGATGATGATCGCCTGCGTGGTGGT
GTTTATTGCCATGCAAATTCTCGGCGATCAGGAAGTGATGTTATGGCTGGCCTGGCCATTCGATCCAACACTGAAATTTG
AGTTCTGGCGTTACTTCACCCACGCGTTAATGCACTTCTCGCTGATGCATATCCTCTTTAACCTGCTCTGGTGGTGGTAT
CTCGGCGGTGCGGTGGAAAAACGCCTCGGTAGCGGTAAGCTAATTGTCATTACGCTTATCAGCGCCCTGTTAAGCGGCTA
TGTGCAGCAAAAATTCAGCGGGCCGTGGTTTGGCGGGCTTTCTGGCGTGGTGTATGCGCTGATGGGCTACGTCTGGCTAC
GTGGCGAACGCGATCCGCAAAGTGGCATTTACCTGCAACGTGGGTTAATTATCTTTGCGCTGATCTGGATTGTCGCCGGA
TGGTTTGATTTGTTTGGGATGTCGATGGCGAACGGAGCACACATCGCCGGGTTAGCCGTGGGTTTAGCGATGGCTTTTGT
TGATTCGCTCAATGCGCGAAAACGAAAATAA

Upstream 100 bases:

>100_bases
GCGGCTTTGAAGCCTGGCAACGTCAGTTTCCCGCAGAGGTGGCGTACGGCGCGTAACGCTTTATACTGTCCCCTTTTGTG
TGGAATAAGCGACAGCAACG

Downstream 100 bases:

>100_bases
TTCCAGGGATTTATAAATGAAACAAACACAACGTCACAACGGTATTATCGAACTGGTTAAACAGCAGGGTTATGTCAGTA
CCGAAGAGCTGGTAGAGCAT

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK

Sequences:

>Translated_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
>Mature_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

Organism=Escherichia coli, GI48994938, Length=276, Percent_Identity=100, Blast_Score=561, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 31307; Mature: 31307

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPA
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
LWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPA
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
LWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA