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The map label for this gene is lptA

Identifier: 157162684

GI number: 157162684

Start: 3394307

End: 3394864

Strand: Direct

Name: lptA

Synonym: EcHS_A3393

Alternate gene names: 157162684

Gene position: 3394307-3394864 (Clockwise)

Preceding gene: 157162683

Following gene: 157162685

Centisome position: 73.1

GC content: 49.64

Gene sequence:

>558_bases
ATGAAATTCAAAACAAACAAACTCAGCCTTAATCTTGTGCTTGCCAGCTCACTTCTGGCCGCCAGCATTCCGGCATTTGC
CGTAACCGGAGACACTGATCAGCCGATCCACATTGAATCGGACCAGCAATCTCTTGATATGCAAGGCAACGTGGTTACCT
TTACCGGTAATGTCATCGTCACCCAGGGCACCATCAAAATTAATGCCGACAAAGTGGTCGTTACCCGTCCGGGCGGCGAA
CAAGGTAAAGAAGTGATTGACGGCTACGGTAAACCGGCAACGTTCTACCAGATGCAGGACAACGGTAAACCCGTTGAAGG
TCACGCTTCCCAGATGCACTACGAACTGGCAAAAGATTTTGTCGTTCTGACGGGTAATGCTTATCTGCAGCAGGTCGATA
GCAACATTAAGGGCGATAAGATCACTTACCTGGTGAAAGAGCAGAAAATGCAGGCTTTCAGCGACAAAGGCAAGCGCGTA
ACCACCGTTCTGGTGCCGTCGCAGCTGCAGGATAAAAACAACAAAGGCCAGACCCCGGCACAGAAGAAGGGTAATTAA

Upstream 100 bases:

>100_bases
GTCACGTTATACGGAACAACATTTAACTCCAGCGGTCTGAAAATGCGCGGCAACTTACGCAGCAAGAACGCCGAGCTGAT
TGAAAAGGTTAGAACATCCT

Downstream 100 bases:

>100_bases
TTCGTTATGGCAACATTAACTGCAAAGAACCTTGCAAAAGCCTATAAAGGCCGTCGCGTGGTAGAAGACGTCAGCCTGAC
CGTCAACTCCGGGGAAATCG

Product: lipopolysaccharide transport periplasmic protein LptA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIVTQGTIKINADKVVVTRPGGE
QGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDFVVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRV
TTVLVPSQLQDKNNKGQTPAQKKGN

Sequences:

>Translated_185_residues
MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIVTQGTIKINADKVVVTRPGGE
QGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDFVVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRV
TTVLVPSQLQDKNNKGQTPAQKKGN
>Mature_185_residues
MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIVTQGTIKINADKVVVTRPGGE
QGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDFVVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRV
TTVLVPSQLQDKNNKGQTPAQKKGN

Specific function: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain

COG id: COG1934

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptA family

Homologues:

Organism=Escherichia coli, GI1789592, Length=185, Percent_Identity=100, Blast_Score=375, Evalue=1e-106,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): LPTA_ECO57 (P0ADV3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85984
- PIR:   G91138
- RefSeq:   NP_289774.1
- RefSeq:   NP_312106.1
- ProteinModelPortal:   P0ADV3
- SMR:   P0ADV3
- EnsemblBacteria:   EBESCT00000025618
- EnsemblBacteria:   EBESCT00000058172
- GeneID:   916075
- GeneID:   958639
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4563
- KEGG:   ecs:ECs4079
- GeneTree:   EBGT00050000009111
- HOGENOM:   HBG701445
- OMA:   VTFTDNV
- ProtClustDB:   PRK10894
- BioCyc:   ECOL83334:ECS4079-MONOMER
- GO:   GO:0006810
- InterPro:   IPR014340
- InterPro:   IPR005653
- TIGRFAMs:   TIGR03002

Pfam domain/function: PF03968 OstA

EC number: NA

Molecular weight: Translated: 20127; Mature: 20127

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIV
CCEECCEEEEEEEEHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCEEEEECCEEE
TQGTIKINADKVVVTRPGGEQGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDF
EECEEEECCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCE
VVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVLVPSQLQDKNNKGQTPA
EEEECCHHHHHHCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEEEECCHHCCCCCCCCCCC
QKKGN
CCCCC
>Mature Secondary Structure
MKFKTNKLSLNLVLASSLLAASIPAFAVTGDTDQPIHIESDQQSLDMQGNVVTFTGNVIV
CCEECCEEEEEEEEHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCEEEEECCEEE
TQGTIKINADKVVVTRPGGEQGKEVIDGYGKPATFYQMQDNGKPVEGHASQMHYELAKDF
EECEEEECCCEEEEECCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCE
VVLTGNAYLQQVDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVLVPSQLQDKNNKGQTPA
EEEECCHHHHHHCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEEEECCHHCCCCCCCCCCC
QKKGN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796