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The map label for this gene is zupT

Identifier: 157162515

GI number: 157162515

Start: 3227381

End: 3228154

Strand: Direct

Name: zupT

Synonym: EcHS_A3217

Alternate gene names: 157162515

Gene position: 3227381-3228154 (Clockwise)

Preceding gene: 157162513

Following gene: 157162518

Centisome position: 69.5

GC content: 52.58

Gene sequence:

>774_bases
ATGTCAGTACCTCTCATTCTGACCATACTGGCGGGGGCAGCCACGTTTATTGGCGCGTTTCTCGGCGTTCTCGGGCAAAA
ACCCTCGAACCGCTTACTGGCGTTTTCGCTAGGTTTTGCGGCGGGGATCATGTTGCTCATCTCATTAATGGAAATGCTTC
CTGCCGCACTAGCAGCTGAAGGAATGTCGCCTGTGTTGGGTTATGGAATGTTTATCTTCGGTCTGCTTGGCTATTTTGGC
CTGGACCGCATGTTGCCACATGCTCATCCGCAGGATTTAATGCAAAAATCGGTGCAGCCGTTGCCAAAATCGATCAAGCG
CACAGCCATTCTGCTCACTCTCGGCATCAGTCTGCATAACTTCCCGGAAGGGATTGCCACCTTTGTCACGGCGAGCAGCA
ACCTGGAGCTGGGATTTGGCATCGCACTGGCCGTCGCGTTGCACAATATTCCTGAAGGTCTGGCGGTTGCAGGCCCGGTT
TATGCAGCAACGGGTTCTAAACGCACGGCAATTCTGTGGGCGGGGATTTCTGGATTGGCAGAAATTCTTGGTGGTGTGCT
GGCGTGGTTAATCCTCGGTAGCATGATTTCCCCGGTGGTCATGGCGGCAATCATGGCGGCGGTTGCAGGAATTATGGTGG
CGCTCTCGGTTGATGAATTAATGCCGCTCGCCAAAGAGATTGACCCTAATAATAACCCCAGCTATGGCGTACTATGTGGA
ATGTCAGTGATGGGATTCAGTTTAGTGCTGCTACAAACGGCGGGAATTGGTTAA

Upstream 100 bases:

>100_bases
ATACGCTTGTTCGGCGGAGTAAGAACCCGGATAACAATGATGATGATCATCAGTTATTTTGACGATCTGCCTGAAGGTGA
AGATTTATAAGGAGTTGTCG

Downstream 100 bases:

>100_bases
AAACAACATCAGAAGTTGTCCAGCATATGGACAACTTCTGCCAGCTTCACGAAAGCCTTATTCTACCTTTTCGGCTGTCT
CTTCTCTCGTACTGTTTAAG

Product: zinc transporter ZupT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFG
LDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPV
YAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCG
MSVMGFSLVLLQTAGIG

Sequences:

>Translated_257_residues
MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFG
LDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPV
YAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCG
MSVMGFSLVLLQTAGIG
>Mature_256_residues
SVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGL
DRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVY
AATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGM
SVMGFSLVLLQTAGIG

Specific function: Mediates zinc uptake. May also transport other divalent cations

COG id: COG0428

COG function: function code P; Predicted divalent heavy-metal cations transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily

Homologues:

Organism=Homo sapiens, GI229577422, Length=153, Percent_Identity=32.0261437908497, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI229577418, Length=153, Percent_Identity=32.0261437908497, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789419, Length=257, Percent_Identity=100, Blast_Score=497, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24652846, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZUPT_ECO24 (A7ZRS2)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001464501.1
- ProteinModelPortal:   A7ZRS2
- STRING:   A7ZRS2
- EnsemblBacteria:   EBESCT00000020788
- GeneID:   5590025
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_3504
- eggNOG:   COG0428
- GeneTree:   EBGT00050000010708
- HOGENOM:   HBG620552
- OMA:   VSVPIYY
- ProtClustDB:   PRK04201
- BioCyc:   ECOL331111:ECE24377A_3504-MONOMER
- HAMAP:   MF_00548
- InterPro:   IPR003689

Pfam domain/function: PF02535 Zip

EC number: NA

Molecular weight: Translated: 26485; Mature: 26354

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17464bfc)-; HASH(0x17692130)-; HASH(0x171fd61c)-; HASH(0x16dd2a58)-; HASH(0x1777f370)-; HASH(0x176b03a8)-; HASH(0x17709098)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHN
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
FPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCHHCCCCCCCEEEEECCHHHHH
EILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
MSVMGFSLVLLQTAGIG
HHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
SVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHN
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
FPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHCCCHHCCCCCCCEEEEECCHHHHH
EILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
MSVMGFSLVLLQTAGIG
HHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA