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The map label for this gene is yggW [H]

Identifier: 157162416

GI number: 157162416

Start: 3126185

End: 3127321

Strand: Direct

Name: yggW [H]

Synonym: EcHS_A3115

Alternate gene names: 157162416

Gene position: 3126185-3127321 (Clockwise)

Preceding gene: 157162415

Following gene: 157162423

Centisome position: 67.32

GC content: 53.21

Gene sequence:

>1137_bases
ATGGTTAAATTACCGCCGCTGAGTCTCTACATTCACATCCCGTGGTGCGTGCAGAAATGCCCGTACTGCGATTTCAACTC
TCACGCGTTGAAAGGAGAAGTGCCGCACGACGATTACGTTCAGCATCTGCTTTGCGATCTGGACAATGATGTGGCTTACG
CTCAGGGCCGTGAAGTAAAGACAATCTTTATTGGCGGTGGTACGCCGAGCCTGCTTTCCGGCCCGGCGATGCAAACGCTG
CTGGACGGCGTGCGTGCGCGTTTGCCGCTGGCAGCGGATGCAGAAATTACTATGGAAGCGAACCCTGGTACGGTAGAAGC
CGATCGCTTTGTCGATTATCAGCGTGCTGGTGTGAACCGCATCTCTATTGGTGTGCAGAGTTTTAGCGAAGAAAAGCTGA
AACGACTTGGGCGCATTCATGGCCCGCAAGAAGCGAAACGAGCGGCAAAGCTGGCGAGCGGTTTAGGGTTACGTAGCTTT
AACCTTGATTTGATGCATGGACTACCGGATCAATCACTGGAAGAGGCGCTTGGCGATCTACGCCAGGCCATTGAACTGAA
TCCGCCGCATCTTTCCTGGTATCAACTGACCATCGAACCCAATACGCTGTTTGGTTCGCGACCACCGGTGCTGCCGGACG
ACGACGCGCTGTGGGATATATTCGAACAGGGGCATCAGTTATTAACCGCAGCGGGTTATCAGCAATATGAAACTTCCGCT
TACGCCAAACCCAGTTATCAGTGCCAGCACAATCTCAACTACTGGCGCTTTGGCGACTACATCGGTATTGGCTGCGGCGC
GCACGGCAAAGTGACCTTCCCGGATGGGCGCATTCTTCGTACCACTAAAACGCGTCATCCGCGTGGTTTTATGCAAGGAA
GGTATCTGGAAAGCCAGCGTGATGTCGAAGCCGCAGATAAGCCGTTTGAGTTCTTTATGAACCGCTTTCGCTTGCTGGAG
GCCGCGCCACGCGCAGAGTTTAGTGCGTATACCGGGCTTTGCGAAGATGTGATTCGCCCACAGTTAGACGAGGCGATTGC
CCAGGGTTATCTCACCGAATGTGCGGATTACTGGCAGATAACGGAACATGGGAAGCTGTTTTTAAATTCGCTGCTGGAGC
TTTTTCTGGCTGAGTAA

Upstream 100 bases:

>100_bases
CCTTCCGAAGGGAAAACCGCTGCCGAACTGACCCGCGAAGAAAAGAGCGCCATTTCCCACCGTGGTCAGGCATTGAAACT
GCTGTTGGACGCTTTACGTA

Downstream 100 bases:

>100_bases
ACTTGTATTGCCGGATGCGGCGTGAACGCCTTATCCAGCCGACATGTGGCAGCGGTTGTAGGTCTGATAAGACGCGCAAG
CGTCGCATCAGACGTTGATT

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLCDLDNDVAYAQGREVKTIFIGGGTPSLLSGPAMQTL
LDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSF
NLDLMHGLPDQSLEEALGDLRQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSA
YAKPSYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQRDVEAADKPFEFFMNRFRLLE
AAPRAEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQITEHGKLFLNSLLELFLAE

Sequences:

>Translated_378_residues
MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLCDLDNDVAYAQGREVKTIFIGGGTPSLLSGPAMQTL
LDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSF
NLDLMHGLPDQSLEEALGDLRQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSA
YAKPSYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQRDVEAADKPFEFFMNRFRLLE
AAPRAEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQITEHGKLFLNSLLELFLAE
>Mature_378_residues
MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLCDLDNDVAYAQGREVKTIFIGGGTPSLLSGPAMQTL
LDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSF
NLDLMHGLPDQSLEEALGDLRQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSA
YAKPSYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQRDVEAADKPFEFFMNRFRLLE
AAPRAEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQITEHGKLFLNSLLELFLAE

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=284, Percent_Identity=35.5633802816901, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1789325, Length=378, Percent_Identity=98.6772486772487, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI87082341, Length=244, Percent_Identity=32.7868852459016, Blast_Score=128, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 42520; Mature: 42520

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLCDLDNDVAYAQGREVK
CCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEE
TIFIGGGTPSLLSGPAMQTLLDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNR
EEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCE
ISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSFNLDLMHGLPDQSLEEALGDL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHHHHH
RQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSA
HHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCC
YAKPSYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQR
CCCCCCCHHCCCCEEEECCEEEECCCCCCEEECCCCCEEEECCCCCCCCHHCCCCCCCCC
DVEAADKPFEFFMNRFRLLEAAPRAEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQI
CCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHGKLFLNSLLELFLAE
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKLPPLSLYIHIPWCVQKCPYCDFNSHALKGEVPHDDYVQHLLCDLDNDVAYAQGREVK
CCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEE
TIFIGGGTPSLLSGPAMQTLLDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNR
EEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCE
ISIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSFNLDLMHGLPDQSLEEALGDL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHHHHH
RQAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSA
HHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCC
YAKPSYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFMQGRYLESQR
CCCCCCCHHCCCCEEEECCEEEECCCCCCEEECCCCCEEEECCCCCCCCHHCCCCCCCCC
DVEAADKPFEFFMNRFRLLEAAPRAEFSAYTGLCEDVIRPQLDEAIAQGYLTECADYWQI
CCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHGKLFLNSLLELFLAE
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]