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The map label for this gene is ccmB

Identifier: 157161681

GI number: 157161681

Start: 2337341

End: 2338003

Strand: Reverse

Name: ccmB

Synonym: EcHS_A2338

Alternate gene names: 157161681

Gene position: 2338003-2337341 (Counterclockwise)

Preceding gene: 157161682

Following gene: 157161680

Centisome position: 50.35

GC content: 55.81

Gene sequence:

>663_bases
ATGATGTTCTGGCGCATTTTCCGTCTTGAGCTGCGTGTAGCGTTTCGCCATAGCGCCGAAATCGCCAACCCGCTGTGGTT
CTTCCTGATTGTAATTACCCTTTTTCCGCTCAGTATCGGTCCGGAGCCGCAACTGCTGGCGCGTATTGCACCGGGCATTA
TCTGGGTTGCTGCGCTGCTTTCATCCTTGCTGGCGCTGGAACGACTGTTCCGTGACGATTTGCAGGACGGCAGTCTTGAA
CAATTGATGTTGTTGCCGTTACCCTTGCCCGCCGTTGTGCTGGCGAAGGTGATGGCGCACTGGATGGTAACCGGTCTGCC
GTTACTCATCCTTTCGCCACTGGTAGCAATGCTACTGGGAATGGATGTTTATGGCTGGCAAGTGATGGCGCTGACGCTGC
TGCTGGGAACGCCTACGCTTGGCTTTCTCGGTGCACCGGGTGTGGCGTTGACAGTGGGACTTAAGCGCGGTGGTGTGCTG
CTCAGCATACTGGTGTTACCGCTGACTATCCCATTACTCATCTTTGCCACCGCCGCGATGGACGCGGCTTCCATGCATTT
GCCCGTTGACGGGTATCTGGCAATTTTAGGCGCGTTGCTGGCAGGCACCGCGACATTAAGTCCTTTTGCGACGGCGGCAG
CGTTACGAATCAGCATTCAATAA

Upstream 100 bases:

>100_bases
ATACGGAGCAGGGGGGGATTGTGATTCTGACTACCCACCAGCCGCTCAACGTTGCTGAAAGTAAAATTCGCCGCATTTCA
CTGACGCAAACGAGGGCCGC

Downstream 100 bases:

>100_bases
CGCTGGATTACTGATTTTTGTTCGAGTCTGGTATCGAAACTATGTGGAAAACACTGCATCAACTGGCGATCCCACCACGG
CTGTATCAAATCTGTGGCTG

Product: heme exporter protein CcmB

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein CcmB

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLE
QLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVL
LSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ

Sequences:

>Translated_220_residues
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLE
QLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVL
LSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ
>Mature_220_residues
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALLSSLLALERLFRDDLQDGSLE
QLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLGMDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVL
LSILVLPLTIPLLIFATAAMDAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

COG id: COG2386

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmB/CycW/HelB family

Homologues:

Organism=Escherichia coli, GI1788528, Length=220, Percent_Identity=100, Blast_Score=415, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMB_ECO57 (P0ABM0)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A91015
- RefSeq:   NP_288780.1
- RefSeq:   NP_311116.1
- ProteinModelPortal:   P0ABM0
- EnsemblBacteria:   EBESCT00000025058
- EnsemblBacteria:   EBESCT00000057121
- GeneID:   916795
- GeneID:   957177
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3457
- KEGG:   ecs:ECs3089
- GeneTree:   EBGT00050000011611
- HOGENOM:   HBG656580
- OMA:   AKVVAHW
- ProtClustDB:   CLSK880332
- BioCyc:   ECOL83334:ECS3089-MONOMER
- InterPro:   IPR003544
- PRINTS:   PR01414
- TIGRFAMs:   TIGR01190

Pfam domain/function: PF03379 CcmB

EC number: NA

Molecular weight: Translated: 23619; Mature: 23619

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15f01af0)-; HASH(0x1573cd8c)-; HASH(0x1617b8a8)-; HASH(0x16025c70)-; HASH(0x1591eacc)-; HASH(0x13f327f0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLG
HHHHHHHHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
MDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAM
CCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEECH
>Mature Secondary Structure
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLG
HHHHHHHHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
MDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAM
CCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
DAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ
HHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHEEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796