BacMap

Definition	Escherichia coli HS, complete genome.
Accession	NC_009800
Length	4,643,538

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The map label for this gene is ccmA [H]

Identifier: 157161682

GI number: 157161682

Start: 2338000

End: 2338617

Strand: Reverse

Name: ccmA [H]

Synonym: EcHS_A2339

Alternate gene names: 157161682

Gene position: 2338617-2338000 (Counterclockwise)

Preceding gene: 157161683

Following gene: 157161681

Centisome position: 50.36

GC content: 55.99

Gene sequence:

>618_bases
ATGCTTGAAGCCAGAGAGTTACTTTGTGAGCGGGATGAACGAACCTTATTTAGTGGCTTGTCATTTACGCTGAACGCAGG
AGAGTGGGTACAAATCACCGGTAGCAACGGCGCGGGGAAGACAACGCTTCTCCGTTTGCTGACGGGGTTGTCTCGCCCTG
ACGCAGGCGAGGTTCTCTGGCAAGGGCAGCCCTTGCATCAGGTACGCGACAGCTACCATCAAAACCTGTTATGGATAGGC
CATCAGCCGGGGATCAAAACCCGGCTGACGGCGTTAGAAAATCTGCACTTTTATCATCGCGATGGCGATACCGCACAATG
TCTGGAAGCCCTGGCGCAGGCCGGGCTTGCCGGATTCGAAGATATTCCTGTAAATCAGCTCTCGGCCGGGCAACAACGCC
GCGTCGCTTTAGCGCGTCTGTGGCTGACCCGTGCCACGTTATGGATCCTCGACGAGCCTTTTACCGCGATTGACGTTAAC
GGCGTCGATCGTCTGACCCAGCGTATGGCGCAGCATACGGAGCAGGGGGGGATTGTGATTCTGACTACCCACCAGCCGCT
CAACGTTGCTGAAAGTAAAATTCGCCGCATTTCACTGACGCAAACGAGGGCCGCATGA

Upstream 100 bases:

>100_bases
AGATGGGCAAACCTGTATTGATTGCCATAAAGGGATAGCGCACAAGCTGCCCGATATGCGTGAAGTCGAGCCAGGTTTTT
AACAGGGTTATTGCGTGGGT

Downstream 100 bases:

>100_bases
TGTTCTGGCGCATTTTCCGTCTTGAGCTGCGTGTAGCGTTTCGCCATAGCGCCGAAATCGCCAACCCGCTGTGGTTCTTC
CTGATTGTAATTACCCTTTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA

Sequences:

>Translated_205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA
>Mature_205_residues
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIG
HQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVN
GVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=29.7029702970297, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI9665248, Length=194, Percent_Identity=30.9278350515464, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI153792144, Length=201, Percent_Identity=29.8507462686567, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI27477115, Length=210, Percent_Identity=28.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI73747915, Length=161, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI6005701, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI73747917, Length=161, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI27881501, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI30795238, Length=175, Percent_Identity=27.4285714285714, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI255708477, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI11967969, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI105990541, Length=171, Percent_Identity=29.2397660818713, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI148612844, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI45446740, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI47078218, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI21536376, Length=174, Percent_Identity=28.735632183908, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI150417984, Length=186, Percent_Identity=26.8817204301075, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082064, Length=205, Percent_Identity=100, Blast_Score=416, Evalue=1e-118,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=30.7228915662651, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI87081834, Length=212, Percent_Identity=28.7735849056604, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=30.3664921465969, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788225, Length=200, Percent_Identity=29, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787041, Length=205, Percent_Identity=28.780487804878, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1787370, Length=154, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788165, Length=153, Percent_Identity=33.9869281045752, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1786703, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789891, Length=199, Percent_Identity=30.6532663316583, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789991, Length=154, Percent_Identity=31.8181818181818, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI48994943, Length=204, Percent_Identity=28.4313725490196, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788897, Length=204, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1787029, Length=180, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI48995001, Length=180, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1789593, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=26.9035532994924, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787547, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1786698, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1789032, Length=149, Percent_Identity=28.1879194630872, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786345, Length=191, Percent_Identity=31.413612565445, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1790190, Length=187, Percent_Identity=26.7379679144385, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790544, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=32, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789873, Length=198, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787112, Length=175, Percent_Identity=29.1428571428571, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1788210, Length=180, Percent_Identity=26.1111111111111, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=29.5918367346939, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788644, Length=196, Percent_Identity=28.0612244897959, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788450, Length=174, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789586, Length=169, Percent_Identity=28.4023668639053, Blast_Score=61, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=205, Percent_Identity=28.2926829268293, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115533608, Length=193, Percent_Identity=28.4974093264249, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=186, Percent_Identity=25.2688172043011, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17543740, Length=195, Percent_Identity=25.1282051282051, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=186, Percent_Identity=27.4193548387097, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=175, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=193, Percent_Identity=26.9430051813472, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567269, Length=193, Percent_Identity=26.4248704663212, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=186, Percent_Identity=24.1935483870968, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=164, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=207, Percent_Identity=25.6038647342995, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323959, Length=175, Percent_Identity=26.8571428571429, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007184, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221500365, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=25.6830601092896, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=25.6830601092896, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574744, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641342, Length=179, Percent_Identity=30.7262569832402, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574533, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22865; Mature: 22865

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLW
CCCHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
QGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFE
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCC
DIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVI
CCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCEEE
LTTHQPLNVAESKIRRISLTQTRAA
EECCCCCHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLW
CCCHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEE
QGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFE
CCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCC
DIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVI
CCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHCCCCCEEE
LTTHQPLNVAESKIRRISLTQTRAA
EECCCCCHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]