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The map label for this gene is hipA

Identifier: 157160981

GI number: 157160981

Start: 1607677

End: 1608999

Strand: Reverse

Name: hipA

Synonym: EcHS_A1590

Alternate gene names: 157160981

Gene position: 1608999-1607677 (Counterclockwise)

Preceding gene: 157160982

Following gene: 157160980

Centisome position: 34.65

GC content: 48.07

Gene sequence:

>1323_bases
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Upstream 100 bases:

>100_bases
CATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCAACAGAA
CAGCAAAATCTGGAGTGGTA

Downstream 100 bases:

>100_bases
GATATGGGGTTTGGTCATTGTTAATGAGCATGACAATCATGACCGCCAACGACTGGATTCTTCCTTGGTTTATATTGGTG
CGCATAATGTATATTATGTT

Product: protein HipA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Sequences:

>Translated_440_residues
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
>Mature_439_residues
PKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYHA
KSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALL
RIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRWN
AERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQA
GGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPA
ALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665

Homologues:

Organism=Escherichia coli, GI1787785, Length=440, Percent_Identity=100, Blast_Score=910, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIPA_ECOLI (P23874)

Other databases:

- EMBL:   M61242
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   F64904
- RefSeq:   AP_002129.1
- RefSeq:   NP_416024.1
- PDB:   2WIU
- PDB:   3DNT
- PDB:   3DNU
- PDB:   3DNV
- PDB:   3FBR
- PDB:   3HZI
- PDBsum:   2WIU
- PDBsum:   3DNT
- PDBsum:   3DNU
- PDBsum:   3DNV
- PDBsum:   3FBR
- PDBsum:   3HZI
- ProteinModelPortal:   P23874
- SMR:   P23874
- DIP:   DIP-9898N
- IntAct:   P23874
- MINT:   MINT-1292260
- STRING:   P23874
- PhosSite:   P23874
- EnsemblBacteria:   EBESCT00000001674
- EnsemblBacteria:   EBESCT00000014476
- GeneID:   946064
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1500
- KEGG:   eco:b1507
- EchoBASE:   EB0438
- EcoGene:   EG10443
- eggNOG:   COG3550
- GeneTree:   EBGT00050000011186
- HOGENOM:   HBG485371
- OMA:   GIAQIMA
- ProtClustDB:   CLSK891752
- BioCyc:   EcoCyc:EG10443-MONOMER
- BioCyc:   MetaCyc:EG10443-MONOMER
- Genevestigator:   P23874
- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508
- TIGRFAMs:   TIGR03071

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N

EC number: NA

Molecular weight: Translated: 49276; Mature: 49145

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNF
CCCEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHCCCCCEEECCCCCCCCCHHHHHHH
FDNLLPDSPIVRDRIVKRYHAKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKL
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHH
TEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALLRIGNDWCIPKGITPTTHII
HHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEE
KLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
ECCHHHCCCCCCCEECHHCCCCCEEEEEEEHHHCCCCCCHHHEECCCEEEEHHHHHHHHC
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQV
CCCCEEEEECCHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
FQWLIGATDGHAKNFSVFIQAGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASK
HHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHCCCCCCCEEEEEHHEECCCCCC
GKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVT
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AVESNVLRLHGRLSREYGSK
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNF
CCEEEECCCCCHHHHHHHHCCCCEECCCHHHHHHHCCCCCEEECCCCCCCCCHHHHHHH
FDNLLPDSPIVRDRIVKRYHAKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKL
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHH
TEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALLRIGNDWCIPKGITPTTHII
HHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCEEE
KLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
ECCHHHCCCCCCCEECHHCCCCCEEEEEEEHHHCCCCCCHHHEECCCEEEEHHHHHHHHC
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQV
CCCCEEEEECCHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
FQWLIGATDGHAKNFSVFIQAGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASK
HHHHHCCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHCCCCCCCEEEEEHHEECCCCCC
GKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVT
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AVESNVLRLHGRLSREYGSK
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189