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The map label for this gene is ydeN [H]

Identifier: 157160974

GI number: 157160974

Start: 1597665

End: 1599347

Strand: Reverse

Name: ydeN [H]

Synonym: EcHS_A1583

Alternate gene names: 157160974

Gene position: 1599347-1597665 (Counterclockwise)

Preceding gene: 157160975

Following gene: 157160973

Centisome position: 34.44

GC content: 44.03

Gene sequence:

>1683_bases
ATGAAGTCTGCATTAAAGAAAAGTGTCGTAAGTACCTCGATATCTTTGATACTGGCATCTGGTATGGCTGCATTTGCTGC
TCATGCGGCAGATGATGTAAAGCTGAAAGCAACCAAAACAAACGTTGCTTTCTCAGACTTTACGCCGACTGAATACAGTA
CCAAAGGAAAGCCAAATATTATCGTACTAACCATGGATGATCTTGGTTATGGACAACTTCCTTTTGATAAGGGATCTTTT
GACCCAAAAACAATGGAAAATCGTGAAGTTGTCGATACCTACAAAATAGGGATAGATAAAGCCATTGAAGCTGCACAAAA
ATCAACGCCGACGCTCCTTTCATTAATGGATGAAGGCGTACGGTTTACTAACGGCTATGTGGCACACGGTGTTTCCGGCC
CCTCCCGTGCCGCAATAATGACCGGTCGAGCTCCCGCCCGCTTTGGTGTCTATTCCAATACCGATGCTCAGGATGGTATT
CCGCTAACAGAAACTTTCTTGCCTGAATTATTCCAGAATCATGGTTATTACACTGCAGCAGTAGGTAAATGGCACTTGTC
AAAAATCAGTAATGTGCCGGTACCGGAAGATAAACAAACACGTGACTATCATGACAACTTCACCACATTTTCTGCGGAAG
AATGGCAACCTCAAAACCGTGGCTTTGATTACTTTATGGGATTCCACGCTGCAGGAACGGCATATTACAACTCCCCTTCA
CTGTTCCAAAATCGTGAACGTGTCCCCGCAAAAGGTTATATCAGCGATCAGTTAACCGATGAGGCAATTGGCGTTGTTGA
TCGTGCCAAAACACTTGACCAGCCTTTTATGCTTTACCTGGCTTATAATGCTCCGCACCTGCCAAATGATAATCCTGCAC
CGGAGCAATATCAGAAGCAATTTAATACCGGTAGTCAAACGGCAGATAACTACTACGCTTCCGTTTATTCTGTTGATCAG
GGTGTAAAACGCATTCTCGAACAACTGAAGAAAAACGGACAGTATGACAATACAATTATTCTCTTTACCTCCGATAATGG
TGCGGTTATCGATGGTCCTCTGCCGCTGAACGGGGCGCAAAAAGGCTATAAGAGTCAGACCTATCCTGGCGGTACTCACA
CCCCAATGTTTATGTGGTGGAAAGGAAAACTTCAACCCGGTAATTATGACAAGCTGATTTCCGCAATGGATTTCTACCCG
ACAGCTCTTGATGCAGCCGATATCAGCATTCCAAAAGACCTTAAGCTGGATGGCGTTTCCTTGCTGCCCTGGTTGCAAGA
TAAGAAACAAGGCGAGCCACATAAAAATCTGACCTGGATAACCTCTTATTCTCACTGGTTTGATGAGGAAAATATTCCAT
TCTGGGATAATTACCACAAATTTGTCCGTCATCAGTCAGACGATTACCCGCATAACCCCAACACTGAGGACTTAAGCCAA
TTCTCTTATACGGTGAGAAATAACGATTATTCGCTTGTCTATACAGTAGAAAACAATCAGTTAGGTCTATACAAACTGAC
GGATCTACAGCAAAAAGATAACCTTGCCGCCGCCAATCCGCAGGTCGTTAAAGAGATGCAAGGCGTGGTAAGAGAGTTTA
TCGACAGCAGCCAGCCACCGCTTAGCGAGGTAAATCAGGAGAAGTTTAACAATATCAAGAAAGCACTAAGCGAAGCGAAA
TAA

Upstream 100 bases:

>100_bases
TAAATCTGCTATCTCTTTATGTGACTAACTTCACTTACATCCACTTATTTCTCTTCGTAAAATTACTTCGGAATTAAGTA
CAATAAGAAGAGGAACATTT

Downstream 100 bases:

>100_bases
CTAAACCTTCATGCGGCGGAATTTTCCGCCGCCTTATTGAGCGAGATAGCGATGCACGTTACAGCCAAGCCCTCCAGTTT
TCAATGTAATCTCAAATGTG

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNIIVLTMDDLGYGQLPFDKGSF
DPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGI
PLTETFLPELFQNHGYYTAAVGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPS
LFQNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPEQYQKQFNTGSQTADNYYASVYSVDQ
GVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQKGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYP
TALDAADISIPKDLKLDGVSLLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQ
FSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPPLSEVNQEKFNNIKKALSEAK

Sequences:

>Translated_560_residues
MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNIIVLTMDDLGYGQLPFDKGSF
DPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGI
PLTETFLPELFQNHGYYTAAVGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPS
LFQNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPEQYQKQFNTGSQTADNYYASVYSVDQ
GVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQKGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYP
TALDAADISIPKDLKLDGVSLLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQ
FSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPPLSEVNQEKFNNIKKALSEAK
>Mature_560_residues
MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNIIVLTMDDLGYGQLPFDKGSF
DPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGI
PLTETFLPELFQNHGYYTAAVGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPS
LFQNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPEQYQKQFNTGSQTADNYYASVYSVDQ
GVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQKGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYP
TALDAADISIPKDLKLDGVSLLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQ
FSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPPLSEVNQEKFNNIKKALSEAK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=516, Percent_Identity=26.7441860465116, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI45430057, Length=453, Percent_Identity=26.7108167770419, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI146229331, Length=412, Percent_Identity=26.9417475728155, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI146229329, Length=412, Percent_Identity=26.9417475728155, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI6005990, Length=412, Percent_Identity=26.9417475728155, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI146229324, Length=412, Percent_Identity=26.9417475728155, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI59797060, Length=357, Percent_Identity=26.890756302521, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI109389362, Length=347, Percent_Identity=27.3775216138329, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI38569407, Length=345, Percent_Identity=26.9565217391304, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI38569405, Length=386, Percent_Identity=25.6476683937824, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI31742482, Length=180, Percent_Identity=31.6666666666667, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI58743319, Length=181, Percent_Identity=31.4917127071823, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI146229327, Length=311, Percent_Identity=25.08038585209, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI157266309, Length=183, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI53831991, Length=185, Percent_Identity=30.2702702702703, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71852586, Length=180, Percent_Identity=30, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI71852584, Length=180, Percent_Identity=30, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081924, Length=560, Percent_Identity=99.6428571428571, Blast_Score=1159, Evalue=0.0,
Organism=Escherichia coli, GI1790233, Length=450, Percent_Identity=26.8888888888889, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI115533416, Length=515, Percent_Identity=24.4660194174757, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI115533418, Length=465, Percent_Identity=25.5913978494624, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17559078, Length=172, Percent_Identity=32.5581395348837, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24666109, Length=416, Percent_Identity=29.3269230769231, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24666175, Length=408, Percent_Identity=28.4313725490196, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281366397, Length=395, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281366395, Length=395, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24666163, Length=395, Percent_Identity=29.1139240506329, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281363223, Length=378, Percent_Identity=26.1904761904762, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356831, Length=402, Percent_Identity=22.1393034825871, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: 3.1.6.- [C]

Molecular weight: Translated: 62817; Mature: 62817

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECEEEECCCCCCCCCCCCCCCE
IVLTMDDLGYGQLPFDKGSFDPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHCCC
RFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGIPLTETFLPELFQNHGYYTAA
EECCCEEEECCCCCCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
VGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPS
ECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCEEECCCH
LFQNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPEQYQKQ
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHH
FNTGSQTADNYYASVYSVDQGVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQ
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCC
KGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYPTALDAADISIPKDLKLDGVS
CCCCCCCCCCCCCCCEEEEEECEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQ
ECCCHHHHCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
FSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPP
HEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
LSEVNQEKFNNIKKALSEAK
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECEEEECCCCCCCCCCCCCCCE
IVLTMDDLGYGQLPFDKGSFDPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHCCC
RFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGIPLTETFLPELFQNHGYYTAA
EECCCEEEECCCCCCCEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
VGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPS
ECCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCCEEECCCH
LFQNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPEQYQKQ
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHH
FNTGSQTADNYYASVYSVDQGVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQ
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCC
KGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYPTALDAADISIPKDLKLDGVS
CCCCCCCCCCCCCCCEEEEEECEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQ
ECCCHHHHCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
FSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPP
HEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
LSEVNQEKFNNIKKALSEAK
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]