Click here to switch to the map view.

The map label for this gene is ycbZ

Identifier: 157160476

GI number: 157160476

Start: 1078153

End: 1079913

Strand: Reverse

Name: ycbZ

Synonym: EcHS_A1064

Alternate gene names: 157160476

Gene position: 1079913-1078153 (Counterclockwise)

Preceding gene: 157160478

Following gene: 157160475

Centisome position: 23.26

GC content: 51.85

Gene sequence:

>1761_bases
TTGACCATTACGAAACTTGCATGGCGTGACCTGGTTCCTGATACCGATAGCTATCAGGAAATATTTGCTCAGCCACATTT
GATTGACGAAAACGATCCTTTATTCAGTGATACTCAACCGCGGCTGCAATTTGCGCTGGAGCAGTTGCTGCATACGCGAG
CATCCTCCTCTTTTATGCTGGCGAAGGCCCCGGAAGAGTCTGAGTATCTGAATCTTATTGCCAATGCCGCGCGTACGCTA
CAAAGCGATGCAGGCCAACTGGTGGGCGGTCACTATGAGGTTTCCGGCCACTCCATCCGCTTACGTCACGCAGTGAGTGC
AGATGATAATTTTGCGACTTTAACGCAAGTTGTCGCTGCCGACTGGGTAGAAGCGGAGCAACTCTTTGGCTGCCTGCGCC
AGTTTAATGGCGACATTACCCTGCAGCCTGGTCTGGTGCATCAGGCAAATGGCGGTATTCTCATCATCTCTTTGCGTACA
CTGCTGGCGCAACCTCTGCTGTGGATGCGGCTGAAAAATATCGTTAACCGCGAGCGTTTTGACTGGGTTGCGTTTGATGA
GTCGCGCCCTCTCCCCGTCTCTGTGCCTTCGATGCCATTGAAGCTGAAAGTCATTCTGGTAGGCGAACGCGAATCATTGG
CTGATTTCCAGGAGATGGAGCCAGAGCTTTCAGAGCAGGCTATTTATAGCGAATTTGAAGATACTCTGCAGATTGTCGAT
GCGGAGTCAGTAACCCAGTGGTGTCGCTGGGTGACATTTACCGCCAGACATAATCACTTACCTGCACCGGGAGCGGATGC
CTGGCCGATACTTATCCGCGAAGCAGCACGCTACACCGGTGAACAAGAAACACTTCCGCTTAGCCCGCAGTGGATCCTCC
GCCAGTGTAAAGAGGTCGCCTCCCTGTGTGATGGCGACACCTTCTCCGGCGAGCAGCTAAACTTAATGCTGCAGCAGCGT
GAATGGCGCGAAGGTTTCCTCGCTGAACGTATGCAGGATGAGATCCTTCAGGAGCAAATCCTGATTGAAACCGAAGGCGA
ACGCATCGGGCAAATTAACGCCCTTTCGGTCATTGAATTTCCGGGTCATCCACGCGCTTTTGGCGAACCTTCTCGCATTA
GCTGCGTTGTGCATATTGGCGATGGTGAATTCACCGACATCGAACGCAAAGCGGAGCTTGGCGGCAATATCCATGCGAAA
GGGATGATGATCATGCAAGCGTTCCTGATGTCGGAACTACAGCTTGAGCAACAGATCCCCTTCTCAGCATCGCTGACATT
TGAGCAGTCATACAGTGAAGTTGATGGAGATAGTGCCTCGATGGCTGAACTCTGCGCCCTGATAAGCGCCCTCGCCGATG
TGCCGGTGAATCAGAGTATCGCTATCACAGGTTCAGTCGATCAGTTCGGTCGCGCCCAGCCGGTCGGTGGTTTAAATGAG
AAAATCGAAGGCTTCTTTGCTATTTGCCAGCAACGTGAGTTAACCGGGAAACAAGGTGTCATTATCCCCACAGCTAACGT
TCGCCATTTAAGTCTTCACAGTGAACTGGTGAAAGCGGTAGAAGAAGGCAAATTCACCATCTGGGCAGTAGACGATGTGA
CTGACGCACTGCCGTTATTATTAAATCTGGTGTGGGATGGCGAAGGCCAAACGACGCTGATGCAAACCATCCAGGAACGT
ATCGCGCAAGCATCGCAACAGGAAGGACGTCACCGTTTTCCATGGCCATTACGTTGGCTGAACTGGTTTATTCCGAACTG
A

Upstream 100 bases:

>100_bases
TAACGCCCATGCCAGGAGTATTGTCGGTGCTTTCTACGTGTGCTGTAGTGCCGGTTACGGTATAATCGCGGCTTTGACAA
CAGACTAAAAAACATCAACT

Downstream 100 bases:

>100_bases
TCGGACTTGTTCAGCGTACACGTGTTAGCTATCCTGCGTGCTTCAATAAAATAAGGCTTACAGAGAACATGGTAGATAAA
CGCGAATCCTATACAAAAGA

Product: S16 family peptidase

Products: NA

Alternate protein names: ATP-dependent protease La homolog

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MTITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFMLAKAPEESEYLNLIANAARTL
QSDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAADWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRT
LLAQPLLWMRLKNIVNRERFDWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVD
AESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVASLCDGDTFSGEQLNLMLQQR
EWREGFLAERMQDEILQEQILIETEGERIGQINALSVIEFPGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAK
GMMIMQAFLMSELQLEQQIPFSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNE
KIEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLLLNLVWDGEGQTTLMQTIQER
IAQASQQEGRHRFPWPLRWLNWFIPN

Sequences:

>Translated_586_residues
MTITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFMLAKAPEESEYLNLIANAARTL
QSDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAADWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRT
LLAQPLLWMRLKNIVNRERFDWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVD
AESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVASLCDGDTFSGEQLNLMLQQR
EWREGFLAERMQDEILQEQILIETEGERIGQINALSVIEFPGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAK
GMMIMQAFLMSELQLEQQIPFSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNE
KIEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLLLNLVWDGEGQTTLMQTIQER
IAQASQQEGRHRFPWPLRWLNWFIPN
>Mature_585_residues
TITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFMLAKAPEESEYLNLIANAARTLQ
SDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAADWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRTL
LAQPLLWMRLKNIVNRERFDWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVDA
ESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVASLCDGDTFSGEQLNLMLQQRE
WREGFLAERMQDEILQEQILIETEGERIGQINALSVIEFPGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAKG
MMIMQAFLMSELQLEQQIPFSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNEK
IEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLLLNLVWDGEGQTTLMQTIQERI
AQASQQEGRHRFPWPLRWLNWFIPN

Specific function: Unknown

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family

Homologues:

Organism=Escherichia coli, GI1787188, Length=586, Percent_Identity=100, Blast_Score=1201, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LONH_ECOLI (P75867)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   B64836
- RefSeq:   AP_001585.1
- RefSeq:   NP_415475.1
- ProteinModelPortal:   P75867
- SMR:   P75867
- DIP:   DIP-11487N
- STRING:   P75867
- EnsemblBacteria:   EBESCT00000001476
- EnsemblBacteria:   EBESCT00000016157
- GeneID:   945569
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0938
- KEGG:   eco:b0955
- EchoBASE:   EB3482
- EcoGene:   EG13718
- eggNOG:   COG1067
- GeneTree:   EBGT00050000010653
- HOGENOM:   HBG678164
- OMA:   IMQAFLI
- ProtClustDB:   CLSK879860
- BioCyc:   EcoCyc:G6493-MONOMER
- Genevestigator:   P75867
- GO:   GO:0006508
- InterPro:   IPR008269
- InterPro:   IPR001984
- InterPro:   IPR020568
- PRINTS:   PR00830

Pfam domain/function: PF05362 Lon_C; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.4.21.-

Molecular weight: Translated: 65819; Mature: 65688

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 438-438 ACT_SITE 481-481

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFML
CCCCHHHHHHCCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
AKAPEESEYLNLIANAARTLQSDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAA
EECCCHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHH
DWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRTLLAQPLLWMRLKNIVNRERF
HHHHHHHHHHHHHHHCCCEEECCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCHHHC
DWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVD
CEEEECCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
AESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVA
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SLCDGDTFSGEQLNLMLQQREWREGFLAERMQDEILQEQILIETEGERIGQINALSVIEF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEC
PGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAKGMMIMQAFLMSELQLEQQIP
CCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC
FSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNE
CCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCCCCCCCHH
KIEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLL
HHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHHHCCCEEEEEECHHHHHHHHH
LNLVWDGEGQTTLMQTIQERIAQASQQEGRHRFPWPLRWLNWFIPN
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TITKLAWRDLVPDTDSYQEIFAQPHLIDENDPLFSDTQPRLQFALEQLLHTRASSSFML
CCCHHHHHHCCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
AKAPEESEYLNLIANAARTLQSDAGQLVGGHYEVSGHSIRLRHAVSADDNFATLTQVVAA
EECCCHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHH
DWVEAEQLFGCLRQFNGDITLQPGLVHQANGGILIISLRTLLAQPLLWMRLKNIVNRERF
HHHHHHHHHHHHHHHCCCEEECCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCHHHC
DWVAFDESRPLPVSVPSMPLKLKVILVGERESLADFQEMEPELSEQAIYSEFEDTLQIVD
CEEEECCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
AESVTQWCRWVTFTARHNHLPAPGADAWPILIREAARYTGEQETLPLSPQWILRQCKEVA
HHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SLCDGDTFSGEQLNLMLQQREWREGFLAERMQDEILQEQILIETEGERIGQINALSVIEF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEC
PGHPRAFGEPSRISCVVHIGDGEFTDIERKAELGGNIHAKGMMIMQAFLMSELQLEQQIP
CCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCC
FSASLTFEQSYSEVDGDSASMAELCALISALADVPVNQSIAITGSVDQFGRAQPVGGLNE
CCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCCCCCCCHH
KIEGFFAICQQRELTGKQGVIIPTANVRHLSLHSELVKAVEEGKFTIWAVDDVTDALPLL
HHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHHHCCCEEEEEECHHHHHHHHH
LNLVWDGEGQTTLMQTIQERIAQASQQEGRHRFPWPLRWLNWFIPN
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503