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The map label for this gene is map [H]

Identifier: 156937089

GI number: 156937089

Start: 251198

End: 252118

Strand: Reverse

Name: map [H]

Synonym: Igni_0295

Alternate gene names: 156937089

Gene position: 252118-251198 (Counterclockwise)

Preceding gene: 156937090

Following gene: 156937086

Centisome position: 19.43

GC content: 61.78

Gene sequence:

>921_bases
TTGAGGTCCGGAGAAGCTGTCAGGAGGGCGCTGGAGAGGGGGAGGGAGCTGATAAGGCCCGGCGCCTCGGTTTTAGAGAT
TTGCGAGGAGGTGGAGGACCTAATAAGGAAGCTCTCGGACGGGCCGGCCTTCCCCTGTAACCTGAGCGTGGGTTACGAGG
CCGCCCACTACTCCCCCGTGCCGGAGGACCCGAAGAGGCTCCCGGAGAAGGGGATAGTCAAACTCGACTTGGGCGCCCAC
GTGCGCGGGAGGATCGCGGACTCCGCAATAAGCGTGTTACTCAAGCCCGTGGAGAAACACGAGAAGTTGTCGGAGGCCGT
CAAAGAGGCGCTGGAGAGGGCCTTGGAGAGGGCCAGGCCGGGCCTCTCGGTCTCCGCCATAGGGACCACCATAAGTGTGA
CGATAAGGAGGAAGGGCTTCAAACCGATCTCTAACTTGGGAGGCCACGGCTTGGCCCCCTACTTGGTGCACTCCGGGGTC
TCCATACCCAACGTCCCCGAGCCCTTGCCCTTCAAGCTGGAGCCCGGGCGGGCGTACGCGATAGAGCCCTTCGGCACGGA
CGGGGCCGGGTACGTGGTGGAGGGGAAGGAGGTTACCATCTTCTCCCTCCGGCCTAGGCCCCCCAAGGGGTGGGAGAAGA
GGGCGGGCGACCTAAAAGACTTGGTAGAGGTGATAAACGAAAGGTTCAAGACCCTCCCGTTCTCCCCCCGCTGGCTCACG
GACGTGATGGCTTACGACAAGTTGATGGAAGCTCTGTTGAGGTTATCGAAGATAGGTGTATTAACGGCGTATCCTATACT
CATAGAGGCGAAGAGGGGCGAGGTGGCGCAGTGGGAGCACACCATCTTCGTGACGGAGGAGGGGGTGGTGGTCACCACCG
CCGGCAGCAATAGAGGCTCACCTCGGTCCTCCTCTTCCTAG

Upstream 100 bases:

>100_bases
AATGGTGGGCCAGGTTTAAGGCTAGGGTCGAGGAACTCCTTGAAATACGCCCCCCTAGGAGGGAGGGCGGTGTCAAACCA
TAGAGGAGCTGGAGCTCTAC

Downstream 100 bases:

>100_bases
AGACGTGGAACTCGTAGAGCTGGGGGAGGTGCATCTCGTACCGGGCCAAGGCCTCGCACCGGAAGCCCCTCTCCTCTCCC
AACCTCTTAACGACTTTCCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRSGEAVRRALERGRELIRPGASVLEICEEVEDLIRKLSDGPAFPCNLSVGYEAAHYSPVPEDPKRLPEKGIVKLDLGAH
VRGRIADSAISVLLKPVEKHEKLSEAVKEALERALERARPGLSVSAIGTTISVTIRRKGFKPISNLGGHGLAPYLVHSGV
SIPNVPEPLPFKLEPGRAYAIEPFGTDGAGYVVEGKEVTIFSLRPRPPKGWEKRAGDLKDLVEVINERFKTLPFSPRWLT
DVMAYDKLMEALLRLSKIGVLTAYPILIEAKRGEVAQWEHTIFVTEEGVVVTTAGSNRGSPRSSSS

Sequences:

>Translated_306_residues
MRSGEAVRRALERGRELIRPGASVLEICEEVEDLIRKLSDGPAFPCNLSVGYEAAHYSPVPEDPKRLPEKGIVKLDLGAH
VRGRIADSAISVLLKPVEKHEKLSEAVKEALERALERARPGLSVSAIGTTISVTIRRKGFKPISNLGGHGLAPYLVHSGV
SIPNVPEPLPFKLEPGRAYAIEPFGTDGAGYVVEGKEVTIFSLRPRPPKGWEKRAGDLKDLVEVINERFKTLPFSPRWLT
DVMAYDKLMEALLRLSKIGVLTAYPILIEAKRGEVAQWEHTIFVTEEGVVVTTAGSNRGSPRSSSS
>Mature_306_residues
MRSGEAVRRALERGRELIRPGASVLEICEEVEDLIRKLSDGPAFPCNLSVGYEAAHYSPVPEDPKRLPEKGIVKLDLGAH
VRGRIADSAISVLLKPVEKHEKLSEAVKEALERALERARPGLSVSAIGTTISVTIRRKGFKPISNLGGHGLAPYLVHSGV
SIPNVPEPLPFKLEPGRAYAIEPFGTDGAGYVVEGKEVTIFSLRPRPPKGWEKRAGDLKDLVEVINERFKTLPFSPRWLT
DVMAYDKLMEALLRLSKIGVLTAYPILIEAKRGEVAQWEHTIFVTEEGVVVTTAGSNRGSPRSSSS

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=297, Percent_Identity=35.3535353535354, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI124494254, Length=287, Percent_Identity=24.7386759581882, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17544396, Length=303, Percent_Identity=34.6534653465347, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17542840, Length=301, Percent_Identity=26.578073089701, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319380, Length=320, Percent_Identity=31.875, Blast_Score=148, Evalue=9e-37,
Organism=Drosophila melanogaster, GI17137568, Length=298, Percent_Identity=34.2281879194631, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24658585, Length=315, Percent_Identity=23.1746031746032, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 33468; Mature: 33468

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGEAVRRALERGRELIRPGASVLEICEEVEDLIRKLSDGPAFPCNLSVGYEAAHYSPV
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCC
PEDPKRLPEKGIVKLDLGAHVRGRIADSAISVLLKPVEKHEKLSEAVKEALERALERARP
CCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLSVSAIGTTISVTIRRKGFKPISNLGGHGLAPYLVHSGVSIPNVPEPLPFKLEPGRAYA
CCEEEECCCEEEEEEECCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCEEE
IEPFGTDGAGYVVEGKEVTIFSLRPRPPKGWEKRAGDLKDLVEVINERFKTLPFSPRWLT
ECCCCCCCCCEEEECCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
DVMAYDKLMEALLRLSKIGVLTAYPILIEAKRGEVAQWEHTIFVTEEGVVVTTAGSNRGS
HHHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCC
PRSSSS
CCCCCC
>Mature Secondary Structure
MRSGEAVRRALERGRELIRPGASVLEICEEVEDLIRKLSDGPAFPCNLSVGYEAAHYSPV
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCC
PEDPKRLPEKGIVKLDLGAHVRGRIADSAISVLLKPVEKHEKLSEAVKEALERALERARP
CCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLSVSAIGTTISVTIRRKGFKPISNLGGHGLAPYLVHSGVSIPNVPEPLPFKLEPGRAYA
CCEEEECCCEEEEEEECCCCCCHHHCCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCEEE
IEPFGTDGAGYVVEGKEVTIFSLRPRPPKGWEKRAGDLKDLVEVINERFKTLPFSPRWLT
ECCCCCCCCCEEEECCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
DVMAYDKLMEALLRLSKIGVLTAYPILIEAKRGEVAQWEHTIFVTEEGVVVTTAGSNRGS
HHHHHHHHHHHHHHHHHHHHHEECEEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCC
PRSSSS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]