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The map label for this gene is 156937086

Identifier: 156937086

GI number: 156937086

Start: 247939

End: 249426

Strand: Reverse

Name: 156937086

Synonym: Igni_0292

Alternate gene names: NA

Gene position: 249426-247939 (Counterclockwise)

Preceding gene: 156937089

Following gene: 156937077

Centisome position: 19.22

GC content: 61.29

Gene sequence:

>1488_bases
TTGAAGCTCAGAGCGGGAGTGGTCCAGAGGGCCTTGAGCTACATAGCCGAAGAGATGGGAAGCGTGTTGAAACGTTCGTC
CGTTTCCCCGAACATTAGAGAACGCTTGGACATGTCTTGCGCCTTGCTGGACGAGGACGGGAGGGTACTAGCTCAAGCCG
AACACATCCCAGTACACTTGGGCAGCCTCTCGTGGGCGGCCCCGAGGCTGGTTGAGAGGGCCTCGGAGTTGGTCGAGGAT
GAGGGGGACGTCATGATAGTTAACGACCCTTACTTGACCGGCACCCACTTGAACGACGTAACTGTTATGACAAAGTATAA
GAACGTTTGGATAGTTAACAAGGCCCACCACGTGGACGTAGGGGGCCCCGTGCCCGGCTCCCTGAACCCCAACGCCAAGA
CGTTGTTCGAGGAAGGGATAGTAATAGAGCCCGCGCTAGTGGCCAAGAGGTGGAGGGTTTTGAAGGTAGCTGAGGACTTG
GCCAAGGGCGTCAGGGGGCCTAAGACGTTCTTGGCCGACTTGAAGGCACAGATAGCGGCCTTGAGGACCGGCCTCCAGAG
GCTGAGGGAGTTGGAGGACCGTTACGGCGACATTAACGAGTACAAGGAAGACTTCTTAGAGGCGTCCAAGAGGGCCTACT
CGGAGAGGCTGGCCGAGGTGTCGGGGGAGGGGGAGGCCGAAGTCCCCTTGGAGCTCCCGGAGGGCCTCGCGAAAATAAGG
GTGAGGCTCAAGGTCGGGGAAGTCGTGGAGGCGGACTTCTCGGGGTCCTCGGACCAAGTGCCCTACAACTTGAACGCGGT
GGAGGGAATAGCCTACGCCGCGGTGGCCTTCTTCGTGAAGGCGATGACCGTCCCGGAGGGGCCGGTGGACCACGGCCTTT
ATTCTTTAATAAAGGTAAAGACGAGGGAGGGGAGCTTGCTGAACCCCCGGTTCCCCGCCGCCGTAGGGGCCGGGAACTTG
GAGACCTCCCAGAGGGCCTTGGAGGCCGTGGTGCTCGCCGCGCAAGGCTTCTCCCACGCCCCCTCCGGGGGCCCGGGCAC
CATGAGCAACTTGATACTGTCATGGGGGAACAAGGTCTATTATGAAACCAACGCCGGCGGCGGGAGCGCGACCAAGGACT
CGGACGGCCAGAACGCCGTCCAATGGGGCATGACCAACACCATGAACACCCCGATAGAAATAATAGAGAGGGAGGCGCCG
GTGCTATTCACTAGGTACTCCGTGAGGAGGGGCTCCGGAGGGGCCGGGACGCACAAGGGAGGGGACGGGGTGGTTAGGGA
ATTTATAGCCTTGGACGACCTAAAGGTAACCGTGATCATGTCTAGGTACTTGACGAAGTCCCCCGGCGCGAAGGGGGGCT
CGGACGGGGAGCCGGGGGCGGTCTTGGTGGACGGGGAGCCGGTGGAAGGCTACTTCTCCGGGGAACTCAAGAAGGGGTCC
CGGCTGACCCTCATGACCCCGGGCGCCGGGGGCTGGGGTCGAGCTTGA

Upstream 100 bases:

>100_bases
CCGGTCTTTACCCTCTTCACTATCATCCTTCTTCTCCGCGTAAAGTATAGCCCCTTCGAGAGTTTAAACGTTGGAGGGGA
TCAAGTGGGGGTCGCGAAGC

Downstream 100 bases:

>100_bases
GGTCCAAGACGTAGTGCAAGTAGTAGATGCAGTGGGAGGCCAAGTAGCTCTTGGGGCCCAAGGAAACCCTCTCCGCCTCC
AGCCAAGGAGGGAGCTCCAG

Product: 5-oxoprolinase (ATP-hydrolyzing)

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKLRAGVVQRALSYIAEEMGSVLKRSSVSPNIRERLDMSCALLDEDGRVLAQAEHIPVHLGSLSWAAPRLVERASELVED
EGDVMIVNDPYLTGTHLNDVTVMTKYKNVWIVNKAHHVDVGGPVPGSLNPNAKTLFEEGIVIEPALVAKRWRVLKVAEDL
AKGVRGPKTFLADLKAQIAALRTGLQRLRELEDRYGDINEYKEDFLEASKRAYSERLAEVSGEGEAEVPLELPEGLAKIR
VRLKVGEVVEADFSGSSDQVPYNLNAVEGIAYAAVAFFVKAMTVPEGPVDHGLYSLIKVKTREGSLLNPRFPAAVGAGNL
ETSQRALEAVVLAAQGFSHAPSGGPGTMSNLILSWGNKVYYETNAGGGSATKDSDGQNAVQWGMTNTMNTPIEIIEREAP
VLFTRYSVRRGSGGAGTHKGGDGVVREFIALDDLKVTVIMSRYLTKSPGAKGGSDGEPGAVLVDGEPVEGYFSGELKKGS
RLTLMTPGAGGWGRA

Sequences:

>Translated_495_residues
MKLRAGVVQRALSYIAEEMGSVLKRSSVSPNIRERLDMSCALLDEDGRVLAQAEHIPVHLGSLSWAAPRLVERASELVED
EGDVMIVNDPYLTGTHLNDVTVMTKYKNVWIVNKAHHVDVGGPVPGSLNPNAKTLFEEGIVIEPALVAKRWRVLKVAEDL
AKGVRGPKTFLADLKAQIAALRTGLQRLRELEDRYGDINEYKEDFLEASKRAYSERLAEVSGEGEAEVPLELPEGLAKIR
VRLKVGEVVEADFSGSSDQVPYNLNAVEGIAYAAVAFFVKAMTVPEGPVDHGLYSLIKVKTREGSLLNPRFPAAVGAGNL
ETSQRALEAVVLAAQGFSHAPSGGPGTMSNLILSWGNKVYYETNAGGGSATKDSDGQNAVQWGMTNTMNTPIEIIEREAP
VLFTRYSVRRGSGGAGTHKGGDGVVREFIALDDLKVTVIMSRYLTKSPGAKGGSDGEPGAVLVDGEPVEGYFSGELKKGS
RLTLMTPGAGGWGRA
>Mature_495_residues
MKLRAGVVQRALSYIAEEMGSVLKRSSVSPNIRERLDMSCALLDEDGRVLAQAEHIPVHLGSLSWAAPRLVERASELVED
EGDVMIVNDPYLTGTHLNDVTVMTKYKNVWIVNKAHHVDVGGPVPGSLNPNAKTLFEEGIVIEPALVAKRWRVLKVAEDL
AKGVRGPKTFLADLKAQIAALRTGLQRLRELEDRYGDINEYKEDFLEASKRAYSERLAEVSGEGEAEVPLELPEGLAKIR
VRLKVGEVVEADFSGSSDQVPYNLNAVEGIAYAAVAFFVKAMTVPEGPVDHGLYSLIKVKTREGSLLNPRFPAAVGAGNL
ETSQRALEAVVLAAQGFSHAPSGGPGTMSNLILSWGNKVYYETNAGGGSATKDSDGQNAVQWGMTNTMNTPIEIIEREAP
VLFTRYSVRRGSGGAGTHKGGDGVVREFIALDDLKVTVIMSRYLTKSPGAKGGSDGEPGAVLVDGEPVEGYFSGELKKGS
RLTLMTPGAGGWGRA

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=518, Percent_Identity=33.976833976834, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI133901900, Length=524, Percent_Identity=33.0152671755725, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI133901902, Length=502, Percent_Identity=32.6693227091633, Blast_Score=206, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322634, Length=535, Percent_Identity=35.5140186915888, Blast_Score=253, Evalue=5e-68,
Organism=Drosophila melanogaster, GI45550492, Length=517, Percent_Identity=33.8491295938104, Blast_Score=228, Evalue=9e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 53137; Mature: 53137

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRAGVVQRALSYIAEEMGSVLKRSSVSPNIRERLDMSCALLDEDGRVLAQAEHIPVHL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEECCCCCEEEEECCCEEEE
GSLSWAAPRLVERASELVEDEGDVMIVNDPYLTGTHLNDVTVMTKYKNVWIVNKAHHVDV
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCEEEEEEECCEEEEECCEEEEC
GGPVPGSLNPNAKTLFEEGIVIEPALVAKRWRVLKVAEDLAKGVRGPKTFLADLKAQIAA
CCCCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LRTGLQRLRELEDRYGDINEYKEDFLEASKRAYSERLAEVSGEGEAEVPLELPEGLAKIR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHEE
VRLKVGEVVEADFSGSSDQVPYNLNAVEGIAYAAVAFFVKAMTVPEGPVDHGLYSLIKVK
EEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEE
TREGSLLNPRFPAAVGAGNLETSQRALEAVVLAAQGFSHAPSGGPGTMSNLILSWGNKVY
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEE
YETNAGGGSATKDSDGQNAVQWGMTNTMNTPIEIIEREAPVLFTRYSVRRGSGGAGTHKG
EEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCC
GDGVVREFIALDDLKVTVIMSRYLTKSPGAKGGSDGEPGAVLVDGEPVEGYFSGELKKGS
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEECCCCCCCC
RLTLMTPGAGGWGRA
EEEEECCCCCCCCCC
>Mature Secondary Structure
MKLRAGVVQRALSYIAEEMGSVLKRSSVSPNIRERLDMSCALLDEDGRVLAQAEHIPVHL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEECCCCCEEEEECCCEEEE
GSLSWAAPRLVERASELVEDEGDVMIVNDPYLTGTHLNDVTVMTKYKNVWIVNKAHHVDV
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCCCCEEEEEEECCEEEEECCEEEEC
GGPVPGSLNPNAKTLFEEGIVIEPALVAKRWRVLKVAEDLAKGVRGPKTFLADLKAQIAA
CCCCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LRTGLQRLRELEDRYGDINEYKEDFLEASKRAYSERLAEVSGEGEAEVPLELPEGLAKIR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHEE
VRLKVGEVVEADFSGSSDQVPYNLNAVEGIAYAAVAFFVKAMTVPEGPVDHGLYSLIKVK
EEEEECCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEE
TREGSLLNPRFPAAVGAGNLETSQRALEAVVLAAQGFSHAPSGGPGTMSNLILSWGNKVY
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEE
YETNAGGGSATKDSDGQNAVQWGMTNTMNTPIEIIEREAPVLFTRYSVRRGSGGAGTHKG
EEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCC
GDGVVREFIALDDLKVTVIMSRYLTKSPGAKGGSDGEPGAVLVDGEPVEGYFSGELKKGS
CHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEECCCCCCCC
RLTLMTPGAGGWGRA
EEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]