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The map label for this gene is prs [H]

Identifier: 156937047

GI number: 156937047

Start: 218147

End: 219043

Strand: Reverse

Name: prs [H]

Synonym: Igni_0252

Alternate gene names: 156937047

Gene position: 219043-218147 (Counterclockwise)

Preceding gene: 156937048

Following gene: 156937043

Centisome position: 16.88

GC content: 57.86

Gene sequence:

>897_bases
GTGGGTAAGGTGCTATGCTTGACCCCGCCCAAGGGGCTGTGCGACGGCTTGGTGGCTTCCTTGAACGCCGAGGCCCACTT
CATAGAGAGGAAGAAGTTCCCGGACGGGGAGAGCTACGTGCGCATACCCATACCCGTCTCGGGCGAGGACGTACTGGTCG
TACACACCGGCTTCCCCGACCAAAACGATAGGGTAATAGAAGTCTTGCTCACCATAGATACCCTCAAGGACCTAGGCGCC
GAGAGCGTGACCTTGCTCATGCCCTACATGCCCTACGCAAGGCAAGACAGGAGGTTCAGGGAGGGGGAGCCCGTCTCGAT
AAAGACCTTGCTCAAGACGCTTTCTAACCTAGACTTGGACTACTTGGTAGTAGTGGACATACACAAAGAGTACTCCTTGA
GCGAGTTCGGAGGGGGAGCGTTCAACGTCAGCGTCTTACCTTACTTAGCCGAAAAGATAAAAGACGAGGTCGAGGACCCC
TTGGTGCTCGCCCCGGACCGGGGCGCCACTGCTAGGGCGAAGAGCGTCGCGTCCGTTCTAAAGGCGCCTTGGGACTACTT
GGAGAAGAGGAGGGACAGAGTGACGGGCGAAGTGACCATAAGGCCTAAGGAGATAAGCGCGGAGGGCAAGACCGTAATAA
TAGTAGACGACATGGTGTCCACTGGCTCAACGCTGGCCTTGGCGGCGAAGCAGCTCAAGGCGGCCGGGGCCAAGAGGGTC
CTAGCGCTGGTCGCGCACGCGCTCATGGTGGGCGACGCGGAGAACAAGCTCCGGGAGGCCGGAGTGGAGAGGGTCATAAC
GGCTAATACCCTAGCTAGGGACTATCCGACGATAACTAAGGTAATAGACGTGAGTGAGTACCTATCTAACTTCCTAGTGG
AGAAGGGGCTCGCGTGA

Upstream 100 bases:

>100_bases
GGCTTGGGAGAGGCTGAGGCCCTTCGGCGACGTGGTGTGTTTGCTGCGCTTCCCCATTTCTCTATAGGCTCCCCCTCGTC
CCCGGAACCGGGAGAAGGCA

Downstream 100 bases:

>100_bases
GCCAGAGCCCCGCCGCCGAGGCCAGCTCGTGTGCTAGTATCACCTCTTCCGGCAGCCCCCTCCTAACGCTCCTCTCTTCA
ATTATTTTCAATGCCTCTTG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGKVLCLTPPKGLCDGLVASLNAEAHFIERKKFPDGESYVRIPIPVSGEDVLVVHTGFPDQNDRVIEVLLTIDTLKDLGA
ESVTLLMPYMPYARQDRRFREGEPVSIKTLLKTLSNLDLDYLVVVDIHKEYSLSEFGGGAFNVSVLPYLAEKIKDEVEDP
LVLAPDRGATARAKSVASVLKAPWDYLEKRRDRVTGEVTIRPKEISAEGKTVIIVDDMVSTGSTLALAAKQLKAAGAKRV
LALVAHALMVGDAENKLREAGVERVITANTLARDYPTITKVIDVSEYLSNFLVEKGLA

Sequences:

>Translated_298_residues
MGKVLCLTPPKGLCDGLVASLNAEAHFIERKKFPDGESYVRIPIPVSGEDVLVVHTGFPDQNDRVIEVLLTIDTLKDLGA
ESVTLLMPYMPYARQDRRFREGEPVSIKTLLKTLSNLDLDYLVVVDIHKEYSLSEFGGGAFNVSVLPYLAEKIKDEVEDP
LVLAPDRGATARAKSVASVLKAPWDYLEKRRDRVTGEVTIRPKEISAEGKTVIIVDDMVSTGSTLALAAKQLKAAGAKRV
LALVAHALMVGDAENKLREAGVERVITANTLARDYPTITKVIDVSEYLSNFLVEKGLA
>Mature_297_residues
GKVLCLTPPKGLCDGLVASLNAEAHFIERKKFPDGESYVRIPIPVSGEDVLVVHTGFPDQNDRVIEVLLTIDTLKDLGAE
SVTLLMPYMPYARQDRRFREGEPVSIKTLLKTLSNLDLDYLVVVDIHKEYSLSEFGGGAFNVSVLPYLAEKIKDEVEDPL
VLAPDRGATARAKSVASVLKAPWDYLEKRRDRVTGEVTIRPKEISAEGKTVIIVDDMVSTGSTLALAAKQLKAAGAKRVL
ALVAHALMVGDAENKLREAGVERVITANTLARDYPTITKVIDVSEYLSNFLVEKGLA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=267, Percent_Identity=32.2097378277154, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4506127, Length=267, Percent_Identity=31.4606741573034, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4506129, Length=267, Percent_Identity=30.7116104868914, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI84875539, Length=270, Percent_Identity=31.1111111111111, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4506133, Length=293, Percent_Identity=24.5733788395904, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI194018537, Length=291, Percent_Identity=23.3676975945017, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787458, Length=251, Percent_Identity=33.0677290836653, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25149168, Length=247, Percent_Identity=31.1740890688259, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17554704, Length=247, Percent_Identity=31.1740890688259, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17554702, Length=247, Percent_Identity=31.1740890688259, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71989924, Length=247, Percent_Identity=31.1740890688259, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17570245, Length=285, Percent_Identity=23.5087719298246, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321776, Length=287, Percent_Identity=29.9651567944251, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319403, Length=261, Percent_Identity=29.1187739463602, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320946, Length=249, Percent_Identity=28.5140562248996, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322667, Length=166, Percent_Identity=29.5180722891566, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21355239, Length=291, Percent_Identity=31.6151202749141, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551540, Length=286, Percent_Identity=30.7692307692308, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24651458, Length=298, Percent_Identity=24.1610738255034, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651456, Length=298, Percent_Identity=24.1610738255034, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281362873, Length=298, Percent_Identity=24.1610738255034, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651454, Length=298, Percent_Identity=24.1610738255034, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552010, Length=148, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651462, Length=148, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651464, Length=148, Percent_Identity=27.7027027027027, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32587; Mature: 32456

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVLCLTPPKGLCDGLVASLNAEAHFIERKKFPDGESYVRIPIPVSGEDVLVVHTGFPD
CCCEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCC
QNDRVIEVLLTIDTLKDLGAESVTLLMPYMPYARQDRRFREGEPVSIKTLLKTLSNLDLD
CCCCEEEEEHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCCEEHHHHHHHHHHCCCE
YLVVVDIHKEYSLSEFGGGAFNVSVLPYLAEKIKDEVEDPLVLAPDRGATARAKSVASVL
EEEEEEECCCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHH
KAPWDYLEKRRDRVTGEVTIRPKEISAEGKTVIIVDDMVSTGSTLALAAKQLKAAGAKRV
HCCHHHHHHHHHCCCEEEEEECCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LALVAHALMVGDAENKLREAGVERVITANTLARDYPTITKVIDVSEYLSNFLVEKGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GKVLCLTPPKGLCDGLVASLNAEAHFIERKKFPDGESYVRIPIPVSGEDVLVVHTGFPD
CCEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCC
QNDRVIEVLLTIDTLKDLGAESVTLLMPYMPYARQDRRFREGEPVSIKTLLKTLSNLDLD
CCCCEEEEEHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCCEEHHHHHHHHHHCCCE
YLVVVDIHKEYSLSEFGGGAFNVSVLPYLAEKIKDEVEDPLVLAPDRGATARAKSVASVL
EEEEEEECCCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHH
KAPWDYLEKRRDRVTGEVTIRPKEISAEGKTVIIVDDMVSTGSTLALAAKQLKAAGAKRV
HCCHHHHHHHHHCCCEEEEEECCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
LALVAHALMVGDAENKLREAGVERVITANTLARDYPTITKVIDVSEYLSNFLVEKGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]