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The map label for this gene is pyrD [H]

Identifier: 156937022

GI number: 156937022

Start: 199341

End: 200249

Strand: Reverse

Name: pyrD [H]

Synonym: Igni_0227

Alternate gene names: 156937022

Gene position: 200249-199341 (Counterclockwise)

Preceding gene: 156937024

Following gene: 156937021

Centisome position: 15.43

GC content: 62.6

Gene sequence:

>909_bases
GTGCTGGACCTAAGCGCGGACGTGGGCGGGCTGAAGTTGAGACTCCCCCTGATGCCGGCCTCCGGGATATTGGGAGGGAG
CCCGGATGCGTTGGAGGCCGTGGCCAAGAAGGCGAAGGTAGGGGCTCTAGTCACCAAAACGCTCACTCTAGAGCCCCGAA
AGGGGAACGACCCCCCTATAGTGGTCTCCACGCCGTGCGGGCTCGTGAACGCCGTGGGGCTGGCCAACCCCGGAGTCAAG
GTCGCGAAGGAGTTGGTGGAGGTCGGGAGGAAGTACAACCTACCGGTGGTCGTGTCTATAGCTGGTAAGGACGAGCGAGA
GTTCGCGGAGGCCGCTTGGGCTTCCGTGGACGCGGGCGCCAGCGCCTTGGAGTTGAACCTCTCGTGCCCCCACGCGAAGG
GGTTAGGTCTCGAGCTGGGGATGGATATAAATGCCGTTAGGAAGGTAGTAGAGGCCGTGGCCACCACGGTTAACGTGCCG
GTGTTCGCCAAGCTCGGGCTCGTGGACAAGCTCGTGGACACCGCCAGCGCCGCGCTGGACGCTGGGGCGTCCGGCCTGGT
CTTGATAAATACGATAAGGGCCATGGTAATAGATATTGATGTTATGGAACCCGTCCTAACGAACAAAGTAGGCGGGCTGT
CTGGGAGGGCCATCCACCCTATAGCCGTGAGGGCAGTCTATGAAGTCTACAAAGAACTCAAGGCCCCCATCGTCGGCGTC
GGTGGGGTGTACGAGTGGAGGGACGCCGTGGAGCTCGTGTTGGCTGGGGCGAGTGCAGTTCAGATAGGCAGCGCCGTGGC
CGATAAGGGGCTCGGGGTGTTTTCTGAGGTCCTCGCCGGGTTGGCTTGGTGGCTACACTCCAAGGGGTTCCGCTCGCTGA
GGGAGGCCGTGGGGGCTGCGGTGAGGTAA

Upstream 100 bases:

>100_bases
TCAACTACGTTGATGACTCCCTTCCGCAACCCTTGATGCCCGTCGAAGCTTCCGGACCTCCCGATATAATCCTAAGAAAG
TTCTGCGAGGGGGCGACGGG

Downstream 100 bases:

>100_bases
GGTAAAAATGATCCTCCCCGTATAACCTAACGGCGGTGGGCCTCCTTGGCACGCGTCTACCTACTGATTAAGACTGAGTC
GGGCATGGAAGAGAAGGTTT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLDLSADVGGLKLRLPLMPASGILGGSPDALEAVAKKAKVGALVTKTLTLEPRKGNDPPIVVSTPCGLVNAVGLANPGVK
VAKELVEVGRKYNLPVVVSIAGKDEREFAEAAWASVDAGASALELNLSCPHAKGLGLELGMDINAVRKVVEAVATTVNVP
VFAKLGLVDKLVDTASAALDAGASGLVLINTIRAMVIDIDVMEPVLTNKVGGLSGRAIHPIAVRAVYEVYKELKAPIVGV
GGVYEWRDAVELVLAGASAVQIGSAVADKGLGVFSEVLAGLAWWLHSKGFRSLREAVGAAVR

Sequences:

>Translated_302_residues
MLDLSADVGGLKLRLPLMPASGILGGSPDALEAVAKKAKVGALVTKTLTLEPRKGNDPPIVVSTPCGLVNAVGLANPGVK
VAKELVEVGRKYNLPVVVSIAGKDEREFAEAAWASVDAGASALELNLSCPHAKGLGLELGMDINAVRKVVEAVATTVNVP
VFAKLGLVDKLVDTASAALDAGASGLVLINTIRAMVIDIDVMEPVLTNKVGGLSGRAIHPIAVRAVYEVYKELKAPIVGV
GGVYEWRDAVELVLAGASAVQIGSAVADKGLGVFSEVLAGLAWWLHSKGFRSLREAVGAAVR
>Mature_302_residues
MLDLSADVGGLKLRLPLMPASGILGGSPDALEAVAKKAKVGALVTKTLTLEPRKGNDPPIVVSTPCGLVNAVGLANPGVK
VAKELVEVGRKYNLPVVVSIAGKDEREFAEAAWASVDAGASALELNLSCPHAKGLGLELGMDINAVRKVVEAVATTVNVP
VFAKLGLVDKLVDTASAALDAGASGLVLINTIRAMVIDIDVMEPVLTNKVGGLSGRAIHPIAVRAVYEVYKELKAPIVGV
GGVYEWRDAVELVLAGASAVQIGSAVADKGLGVFSEVLAGLAWWLHSKGFRSLREAVGAAVR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=325, Percent_Identity=28.9230769230769, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=27.8787878787879, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87082059, Length=217, Percent_Identity=32.7188940092166, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=324, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=26.0061919504644, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322633, Length=298, Percent_Identity=28.8590604026846, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24640763, Length=316, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18858217, Length=316, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31072; Mature: 31072

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLSADVGGLKLRLPLMPASGILGGSPDALEAVAKKAKVGALVTKTLTLEPRKGNDPPI
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCE
VVSTPCGLVNAVGLANPGVKVAKELVEVGRKYNLPVVVSIAGKDEREFAEAAWASVDAGA
EEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCC
SALELNLSCPHAKGLGLELGMDINAVRKVVEAVATTVNVPVFAKLGLVDKLVDTASAALD
CEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AGASGLVLINTIRAMVIDIDVMEPVLTNKVGGLSGRAIHPIAVRAVYEVYKELKAPIVGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEC
GGVYEWRDAVELVLAGASAVQIGSAVADKGLGVFSEVLAGLAWWLHSKGFRSLREAVGAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VR
CC
>Mature Secondary Structure
MLDLSADVGGLKLRLPLMPASGILGGSPDALEAVAKKAKVGALVTKTLTLEPRKGNDPPI
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCE
VVSTPCGLVNAVGLANPGVKVAKELVEVGRKYNLPVVVSIAGKDEREFAEAAWASVDAGA
EEECCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCC
SALELNLSCPHAKGLGLELGMDINAVRKVVEAVATTVNVPVFAKLGLVDKLVDTASAALD
CEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AGASGLVLINTIRAMVIDIDVMEPVLTNKVGGLSGRAIHPIAVRAVYEVYKELKAPIVGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEC
GGVYEWRDAVELVLAGASAVQIGSAVADKGLGVFSEVLAGLAWWLHSKGFRSLREAVGAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]