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The map label for this gene is tdcB [H]

Identifier: 154248031

GI number: 154248031

Start: 4546394

End: 4547395

Strand: Direct

Name: tdcB [H]

Synonym: Xaut_4110

Alternate gene names: 154248031

Gene position: 4546394-4547395 (Clockwise)

Preceding gene: 154248030

Following gene: 154248032

Centisome position: 85.64

GC content: 73.25

Gene sequence:

>1002_bases
ATGAGCGCCACAACCATCTCCAGTCCCGTCCCGATTCCCTGCGTCGCTGACGTGGAGGCCGCCGCCCGCCGCATCGCCGG
CGTGGCCGTGCGCACGCCCCTCGTATTTTCCCCGATCCTCAGCGAGCGCACCGGCGCGCGCGTGTTCCTGAAGCCGGAGA
CGCTCCAGCGCACCGGCTCCTTCAAGTTCCGTGGCGCCTATAACCGCATGGTGCAGATCCCTGAGGCGGCGCGGGCGGCC
GGCGTGGTCGCCTGCTCGTCGGGCAACCACGCGCAAGGGGTTGCAGCGTCCGCCCGGCTGCTGGGCATGCCGGCGGTGAT
CGTCATGCCCCACGACGCCCCGGCCCTGAAGCGCGACCGCACCCGGGCCCTCGGCGCCGAGGTGGTGGGCTACGACCGCC
GCACCGAGGACCGCGATGCCATCGCCCGCGCCATCGCGCAGGAGCGCGGCGCCATCGTGGTTCCGCCCTATGACGACCCC
CATGTCATCGCCGGGCAGGGCACGGTGGGCCTGGAGATCGTGCAGGACCTCGCCGCGCTGGGCCTTGTCCCGGATCTGGT
GGCGGCCAATGTCTCCGGTGGCGGCCTCGTCGCCGGCATTGCGCTGGCGGTGAAGGCGCAAGCGCCCGGCGCGCGGGTGG
TGGCCTGCGAGCCCGCCGGCTTCGACGACCATGCCCGCTCGTTCCGCTCCGGCGTGCGCGAGCGCAATCCTGAGCCGTCC
GGCTCGTTCTGCGACGCCCTGCTGGCCCCGACCCCCGGCGCGCTGACCTTCGAGATCACCCGCCCGCTGGTGGGCGAGGG
CGCATCCGTCACCGACGCCGAAGTGGCGCGGGCGGTGGCCTTCGCCTTCCTGGAGCTGAAGCTGGTGGTGGAGCCCGGCG
GCGCGGTGGCGCTGGCCTGCCTGCTGGAAGGCCGGCTCGGCGTCTCCGGTGGCACGGCGGTTATCGTGCTCTCCGGCGGC
AATGTGGAGCCCGAGACCTTCATCCGCTGCCTCGCCGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCGGCAGTTCATCGATAATGTGCTCATCGCCCACGACATAGGTCCCATCGCGCGCCGCTATCGCCTTCGCCGCCGG
CGTCGGATAGCGTCCGGCGC

Downstream 100 bases:

>100_bases
GCCTGGCGGTGGCGAATCAGGTGAGGGAGGTCGACGGACGTCCGGCGCTGAAGCTGCGGCTCGGCGGCGCCTATGCGGCG
TTCTTCCTCGCCATGGGCAT

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSATTISSPVPIPCVADVEAAARRIAGVAVRTPLVFSPILSERTGARVFLKPETLQRTGSFKFRGAYNRMVQIPEAARAA
GVVACSSGNHAQGVAASARLLGMPAVIVMPHDAPALKRDRTRALGAEVVGYDRRTEDRDAIARAIAQERGAIVVPPYDDP
HVIAGQGTVGLEIVQDLAALGLVPDLVAANVSGGGLVAGIALAVKAQAPGARVVACEPAGFDDHARSFRSGVRERNPEPS
GSFCDALLAPTPGALTFEITRPLVGEGASVTDAEVARAVAFAFLELKLVVEPGGAVALACLLEGRLGVSGGTAVIVLSGG
NVEPETFIRCLAA

Sequences:

>Translated_333_residues
MSATTISSPVPIPCVADVEAAARRIAGVAVRTPLVFSPILSERTGARVFLKPETLQRTGSFKFRGAYNRMVQIPEAARAA
GVVACSSGNHAQGVAASARLLGMPAVIVMPHDAPALKRDRTRALGAEVVGYDRRTEDRDAIARAIAQERGAIVVPPYDDP
HVIAGQGTVGLEIVQDLAALGLVPDLVAANVSGGGLVAGIALAVKAQAPGARVVACEPAGFDDHARSFRSGVRERNPEPS
GSFCDALLAPTPGALTFEITRPLVGEGASVTDAEVARAVAFAFLELKLVVEPGGAVALACLLEGRLGVSGGTAVIVLSGG
NVEPETFIRCLAA
>Mature_332_residues
SATTISSPVPIPCVADVEAAARRIAGVAVRTPLVFSPILSERTGARVFLKPETLQRTGSFKFRGAYNRMVQIPEAARAAG
VVACSSGNHAQGVAASARLLGMPAVIVMPHDAPALKRDRTRALGAEVVGYDRRTEDRDAIARAIAQERGAIVVPPYDDPH
VIAGQGTVGLEIVQDLAALGLVPDLVAANVSGGGLVAGIALAVKAQAPGARVVACEPAGFDDHARSFRSGVRERNPEPSG
SFCDALLAPTPGALTFEITRPLVGEGASVTDAEVARAVAFAFLELKLVVEPGGAVALACLLEGRLGVSGGTAVIVLSGGN
VEPETFIRCLAA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=37.2611464968153, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI33469958, Length=305, Percent_Identity=28.8524590163934, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI19923959, Length=304, Percent_Identity=29.9342105263158, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789505, Length=320, Percent_Identity=40, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790207, Length=296, Percent_Identity=35.472972972973, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71991565, Length=320, Percent_Identity=35, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=316, Percent_Identity=33.2278481012658, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=27.5862068965517, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322631, Length=318, Percent_Identity=40.251572327044, Blast_Score=213, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320930, Length=292, Percent_Identity=37.3287671232877, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=306, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=35.126582278481, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24645328, Length=224, Percent_Identity=33.4821428571429, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34163; Mature: 34031

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTISSPVPIPCVADVEAAARRIAGVAVRTPLVFSPILSERTGARVFLKPETLQRTGS
CCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHCCC
FKFRGAYNRMVQIPEAARAAGVVACSSGNHAQGVAASARLLGMPAVIVMPHDAPALKRDR
EEEEECCHHEEECCCHHHHCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHH
TRALGAEVVGYDRRTEDRDAIARAIAQERGAIVVPPYDDPHVIAGQGTVGLEIVQDLAAL
HHHHCHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCHHHHHHHHHHHH
GLVPDLVAANVSGGGLVAGIALAVKAQAPGARVVACEPAGFDDHARSFRSGVRERNPEPS
CCCHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
GSFCDALLAPTPGALTFEITRPLVGEGASVTDAEVARAVAFAFLELKLVVEPGGAVALAC
CHHHHHHHCCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEE
LLEGRLGVSGGTAVIVLSGGNVEPETFIRCLAA
HHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
SATTISSPVPIPCVADVEAAARRIAGVAVRTPLVFSPILSERTGARVFLKPETLQRTGS
CCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHCCC
FKFRGAYNRMVQIPEAARAAGVVACSSGNHAQGVAASARLLGMPAVIVMPHDAPALKRDR
EEEEECCHHEEECCCHHHHCCEEEECCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHH
TRALGAEVVGYDRRTEDRDAIARAIAQERGAIVVPPYDDPHVIAGQGTVGLEIVQDLAAL
HHHHCHHHCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCHHHHHHHHHHHH
GLVPDLVAANVSGGGLVAGIALAVKAQAPGARVVACEPAGFDDHARSFRSGVRERNPEPS
CCCHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCC
GSFCDALLAPTPGALTFEITRPLVGEGASVTDAEVARAVAFAFLELKLVVEPGGAVALAC
CHHHHHHHCCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEE
LLEGRLGVSGGTAVIVLSGGNVEPETFIRCLAA
HHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA