Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 154247871

GI number: 154247871

Start: 4369025

End: 4370347

Strand: Direct

Name: atoC [H]

Synonym: Xaut_3948

Alternate gene names: 154247871

Gene position: 4369025-4370347 (Clockwise)

Preceding gene: 154247870

Following gene: 154247872

Centisome position: 82.3

GC content: 65.91

Gene sequence:

>1323_bases
ATGTCGCATGAGCCTCCCGTCATCGGCCTCGTGGAGGACGATCCCATCATGGGCGAGAGCCTCGCGCAGCGGCTCGGCCT
GGAGGGAATGAGGGTGCATTGGTGGCGGACCGGCTGCGCAGCGGTGGCGGATATCCGGAAGATTCGCTTCGAGGCTATCG
TATGCGACATCCGCCTTCCGGATCTCGATGGGGAGGCTGTGTTCCGGGAAGCGGCGCACGTGCCTCGGACGCCGCCTTTC
CTGTTCGTGACCGGCCATGGCGACATCGACCAAGCGGTGCGCCTGATGCGGTCCGGCGCGGCGGACTACGTCACCAAGCC
CTTCGAGATGGAGGACTTCCTGGCGCGGCTCACCGACTTGCTGATGCCGCATGGAACCACGGAAGGCGGCACGTTGGGCG
TCTCACCCGCCATCCGGCAGGTGGAGGCTCTGTTGTGCAGGATGGCTCGCCTGTCCTCCAATCTGCTCATCACGGGGGAG
ACAGGGACAGGTAAGGATGTAGCCGCCCGCTTCATCCATGCGCAATCGCGGCACGCGACCGCGCCGTTTATCGCGGTCAA
CTGCGCCGCCATTCCCGCCGACTTGATGGAAAGCGAGCTGTTCGGCCACGAGCGAGGCGCGTTCACCGGTGCCGCGCAGC
GCCATCTCGGCTATGTGGAGCGCGCCGGCGACGGCACGCTGTTTCTCGACGAGATCGGGGAATTGCGTCCGGAGTTGCAG
GCAAAACTCCTGCGGCTGATCGAGAGCAAGACGTTTCAGAGGGTCGGCGGTGAGCGCGAGATCGCCTTCGGCGGCCGTAT
CGTGACGGCCACCAACGCCGATCTGGCGCTGCGAGTTGTCGAGCGACAATTCCGCGAGGATCTCCTTTACCGCATCAACG
CGGTCAGCATTCGCCTGCCATCTCTGCGGGAGCGCCCCGATGACATCCCATGGCTCATGGAGCGCTTCTTTACGGAATAT
AGCGCGGACACCGAGACCAACCTGAAAGGGATCAGCGCCCTCGCCGAGGAGGCCGCGATGCAGCATCCTTGGCCCGGGAA
TGTGCGGGAGCTGCGGAACCGGATGGAGCGTGCGGTCGCTCTTGCCTTGGGCCCCTGGCTGATGCCCGGGGATCTCTTTC
CCGAGATCGTTCGCGAAGGCGCTGACGCCGGCCTACGGATCGGCTCACTGGAATCCGCGCGCCAGGAGGCGGAGAAGCGT
CACATCCTCCGGGCGCTGTTCGCGACCGCGGGCGAACTCTCCGCCGCCGCCCGGCTCCTCGGCGTTGGGCGCACCACCCT
GTGGGAGAAGATGCGCCGCCTCGGTTTGGGTAGCGACGGCTGA

Upstream 100 bases:

>100_bases
CTGGACGACCTCGGTGCCTCGGCCGAGGTCGAGCGGCCTGAAACGGGGGGAACGCGGATCCGTCTTCTCTTCCCTTTCAT
CGCCCCAATGGAGCTCGCCC

Downstream 100 bases:

>100_bases
CGGCGCGTTCGGGTTTCCGGACAGACGGCGCCGCAGCATGTTCGGGACGGCGGACGTGCTCGCCTCATCTCGCTCGTTAA
ATCATTGAATTCTCTACTCA

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSHEPPVIGLVEDDPIMGESLAQRLGLEGMRVHWWRTGCAAVADIRKIRFEAIVCDIRLPDLDGEAVFREAAHVPRTPPF
LFVTGHGDIDQAVRLMRSGAADYVTKPFEMEDFLARLTDLLMPHGTTEGGTLGVSPAIRQVEALLCRMARLSSNLLITGE
TGTGKDVAARFIHAQSRHATAPFIAVNCAAIPADLMESELFGHERGAFTGAAQRHLGYVERAGDGTLFLDEIGELRPELQ
AKLLRLIESKTFQRVGGEREIAFGGRIVTATNADLALRVVERQFREDLLYRINAVSIRLPSLRERPDDIPWLMERFFTEY
SADTETNLKGISALAEEAAMQHPWPGNVRELRNRMERAVALALGPWLMPGDLFPEIVREGADAGLRIGSLESARQEAEKR
HILRALFATAGELSAAARLLGVGRTTLWEKMRRLGLGSDG

Sequences:

>Translated_440_residues
MSHEPPVIGLVEDDPIMGESLAQRLGLEGMRVHWWRTGCAAVADIRKIRFEAIVCDIRLPDLDGEAVFREAAHVPRTPPF
LFVTGHGDIDQAVRLMRSGAADYVTKPFEMEDFLARLTDLLMPHGTTEGGTLGVSPAIRQVEALLCRMARLSSNLLITGE
TGTGKDVAARFIHAQSRHATAPFIAVNCAAIPADLMESELFGHERGAFTGAAQRHLGYVERAGDGTLFLDEIGELRPELQ
AKLLRLIESKTFQRVGGEREIAFGGRIVTATNADLALRVVERQFREDLLYRINAVSIRLPSLRERPDDIPWLMERFFTEY
SADTETNLKGISALAEEAAMQHPWPGNVRELRNRMERAVALALGPWLMPGDLFPEIVREGADAGLRIGSLESARQEAEKR
HILRALFATAGELSAAARLLGVGRTTLWEKMRRLGLGSDG
>Mature_439_residues
SHEPPVIGLVEDDPIMGESLAQRLGLEGMRVHWWRTGCAAVADIRKIRFEAIVCDIRLPDLDGEAVFREAAHVPRTPPFL
FVTGHGDIDQAVRLMRSGAADYVTKPFEMEDFLARLTDLLMPHGTTEGGTLGVSPAIRQVEALLCRMARLSSNLLITGET
GTGKDVAARFIHAQSRHATAPFIAVNCAAIPADLMESELFGHERGAFTGAAQRHLGYVERAGDGTLFLDEIGELRPELQA
KLLRLIESKTFQRVGGEREIAFGGRIVTATNADLALRVVERQFREDLLYRINAVSIRLPSLRERPDDIPWLMERFFTEYS
ADTETNLKGISALAEEAAMQHPWPGNVRELRNRMERAVALALGPWLMPGDLFPEIVREGADAGLRIGSLESARQEAEKRH
ILRALFATAGELSAAARLLGVGRTTLWEKMRRLGLGSDG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=37.4722838137472, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=37.0786516853933, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=36.2068965517241, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1788905, Length=444, Percent_Identity=34.2342342342342, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=42.2492401215805, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789087, Length=326, Percent_Identity=41.4110429447853, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=39.1167192429022, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=38.7820512820513, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=40.7407407407407, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=38.4858044164038, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081872, Length=229, Percent_Identity=44.5414847161572, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=34.5762711864407, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789828, Length=222, Percent_Identity=40.0900900900901, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1789402, Length=114, Percent_Identity=30.7017543859649, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48570; Mature: 48439

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEPPVIGLVEDDPIMGESLAQRLGLEGMRVHWWRTGCAAVADIRKIRFEAIVCDIRLP
CCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHEEEEEEEEECC
DLDGEAVFREAAHVPRTPPFLFVTGHGDIDQAVRLMRSGAADYVTKPFEMEDFLARLTDL
CCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
LMPHGTTEGGTLGVSPAIRQVEALLCRMARLSSNLLITGETGTGKDVAARFIHAQSRHAT
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCC
APFIAVNCAAIPADLMESELFGHERGAFTGAAQRHLGYVERAGDGTLFLDEIGELRPELQ
CCEEEEEHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHCHHHH
AKLLRLIESKTFQRVGGEREIAFGGRIVTATNADLALRVVERQFREDLLYRINAVSIRLP
HHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEECC
SLRERPDDIPWLMERFFTEYSADTETNLKGISALAEEAAMQHPWPGNVRELRNRMERAVA
HHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LALGPWLMPGDLFPEIVREGADAGLRIGSLESARQEAEKRHILRALFATAGELSAAARLL
HHHCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGRTTLWEKMRRLGLGSDG
HCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SHEPPVIGLVEDDPIMGESLAQRLGLEGMRVHWWRTGCAAVADIRKIRFEAIVCDIRLP
CCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHEEEEEEEEECC
DLDGEAVFREAAHVPRTPPFLFVTGHGDIDQAVRLMRSGAADYVTKPFEMEDFLARLTDL
CCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
LMPHGTTEGGTLGVSPAIRQVEALLCRMARLSSNLLITGETGTGKDVAARFIHAQSRHAT
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCC
APFIAVNCAAIPADLMESELFGHERGAFTGAAQRHLGYVERAGDGTLFLDEIGELRPELQ
CCEEEEEHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHCHHHH
AKLLRLIESKTFQRVGGEREIAFGGRIVTATNADLALRVVERQFREDLLYRINAVSIRLP
HHHHHHHHHHHHHHCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEECC
SLRERPDDIPWLMERFFTEYSADTETNLKGISALAEEAAMQHPWPGNVRELRNRMERAVA
HHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LALGPWLMPGDLFPEIVREGADAGLRIGSLESARQEAEKRHILRALFATAGELSAAARLL
HHHCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGRTTLWEKMRRLGLGSDG
HCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]