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The map label for this gene is hemH [H]

Identifier: 154246753

GI number: 154246753

Start: 3134997

End: 3136058

Strand: Reverse

Name: hemH [H]

Synonym: Xaut_2814

Alternate gene names: 154246753

Gene position: 3136058-3134997 (Counterclockwise)

Preceding gene: 154246755

Following gene: 154246750

Centisome position: 59.07

GC content: 67.14

Gene sequence:

>1062_bases
ATGACCGCCAACGTGCCCGCGTTCTCCCCCGACACGACGCACCTGCCCCCCGACCACCCGAAAGTGGCCTTCGGCCGCAT
CGGCGTGCTCATCGTCAATCTCGGCACGCCGGAGGCCACCGACTACTGGTCCATGCGGGCGTACCTGAAGGAATTCCTCT
CCGACCCGCGGGTGATCGAGGTGAACCGCGCCGTGTGGTGGTTCGTCCTCAACGCCATCATCCTCACCAAGCGGCCCGGC
CCCAAGGGTCGCGACTATGCCAGCATCTGGAACAAGGAACGCAACGAGGGTCCGCTGAAGACCATCACCCGCGACCAGGC
GGAACAGCTTGCGGCGCAGCTCTCGGGCCTTGATTCGCGCATCGTGGTGGATTTCGCCATGCGCTACGGCAAGCCGCCCA
TCGCCGAGCGCCTCGCCGCGCTCCAGGCCCAGGGCTGCGAGCGCATCCTGCTGGTGCCGCTCTATCCGCAATATTCCGCC
GCCACCTCCGCCACCGTCTGCGACAAGGCCTTCGATGCGCTGAAAGCCATGCGCTGGCAGCCGACCCTGCGCGTCGCCCC
GCCCTGGCACGACGATCCCGTCTATATCGATGCGCTGGCCACATCGCTGGAGCGGCATCTGGCGGCCCTCGATTTCGAGC
CCGAGGTGATCCTCGCCTCGTTCCACGGGGTGCCGAAATCCTACCTGCTGAAGGGTGATCCCTACCACTGCCAGTGCGCC
AAGACCGCCCGCCTGCTGCGCGCGCGCCTCGACCTTGACGACAAGCGCTTCCGCCTCACCTTCCAGTCGCGCTTCGGCCG
CGATGAATGGCTGCGCCCCTACACCGACGCGACGGTGAAAGCGCTGGCGGAAAGCGGGGTGAAGCGGCTCGCCGTGGTCA
ATCCCGGCTTCGTCGCCGACTGCCTGGAGACGCTGGAGGAGATCGGGGTGGAGAACCGCGAGATCTTCGAGCACCACGGC
GGCGAGAAATTCGCCGCCATCCCCTGCCTCAATGCCAACGCCGAGGGCATGCGCGTGCTCGCCCACGTGGTGGAGCGGGA
GTTGAAGGGCTGGGTGGGGTAG

Upstream 100 bases:

>100_bases
GCGTATGGATCTGGCCGGGCCTGAAGCGCCGCATCGGCACCCAACCGATTGACGCGCGGGCGCGCAGGCGCCATCTCGCC
GGGACATCTTCGAGGAACCC

Downstream 100 bases:

>100_bases
GCAGCCACCACACTGTAAGAAATTTCCACGGGGATGAGCATTTTTTCAGCGGAGCAGGAGCCAAACCGCTTCCACTCCGC
TAAAAGGCGCGCAACCCCAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTANVPAFSPDTTHLPPDHPKVAFGRIGVLIVNLGTPEATDYWSMRAYLKEFLSDPRVIEVNRAVWWFVLNAIILTKRPG
PKGRDYASIWNKERNEGPLKTITRDQAEQLAAQLSGLDSRIVVDFAMRYGKPPIAERLAALQAQGCERILLVPLYPQYSA
ATSATVCDKAFDALKAMRWQPTLRVAPPWHDDPVYIDALATSLERHLAALDFEPEVILASFHGVPKSYLLKGDPYHCQCA
KTARLLRARLDLDDKRFRLTFQSRFGRDEWLRPYTDATVKALAESGVKRLAVVNPGFVADCLETLEEIGVENREIFEHHG
GEKFAAIPCLNANAEGMRVLAHVVERELKGWVG

Sequences:

>Translated_353_residues
MTANVPAFSPDTTHLPPDHPKVAFGRIGVLIVNLGTPEATDYWSMRAYLKEFLSDPRVIEVNRAVWWFVLNAIILTKRPG
PKGRDYASIWNKERNEGPLKTITRDQAEQLAAQLSGLDSRIVVDFAMRYGKPPIAERLAALQAQGCERILLVPLYPQYSA
ATSATVCDKAFDALKAMRWQPTLRVAPPWHDDPVYIDALATSLERHLAALDFEPEVILASFHGVPKSYLLKGDPYHCQCA
KTARLLRARLDLDDKRFRLTFQSRFGRDEWLRPYTDATVKALAESGVKRLAVVNPGFVADCLETLEEIGVENREIFEHHG
GEKFAAIPCLNANAEGMRVLAHVVERELKGWVG
>Mature_352_residues
TANVPAFSPDTTHLPPDHPKVAFGRIGVLIVNLGTPEATDYWSMRAYLKEFLSDPRVIEVNRAVWWFVLNAIILTKRPGP
KGRDYASIWNKERNEGPLKTITRDQAEQLAAQLSGLDSRIVVDFAMRYGKPPIAERLAALQAQGCERILLVPLYPQYSAA
TSATVCDKAFDALKAMRWQPTLRVAPPWHDDPVYIDALATSLERHLAALDFEPEVILASFHGVPKSYLLKGDPYHCQCAK
TARLLRARLDLDDKRFRLTFQSRFGRDEWLRPYTDATVKALAESGVKRLAVVNPGFVADCLETLEEIGVENREIFEHHGG
EKFAAIPCLNANAEGMRVLAHVVERELKGWVG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=344, Percent_Identity=25, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=25.1497005988024, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786681, Length=319, Percent_Identity=40.1253918495298, Blast_Score=225, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6324750, Length=239, Percent_Identity=26.3598326359833, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17864156, Length=337, Percent_Identity=24.3323442136499, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39598; Mature: 39467

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANVPAFSPDTTHLPPDHPKVAFGRIGVLIVNLGTPEATDYWSMRAYLKEFLSDPRVIE
CCCCCCCCCCCCCCCCCCCCCEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
VNRAVWWFVLNAIILTKRPGPKGRDYASIWNKERNEGPLKTITRDQAEQLAAQLSGLDSR
ECHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
IVVDFAMRYGKPPIAERLAALQAQGCERILLVPLYPQYSAATSATVCDKAFDALKAMRWQ
HHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
PTLRVAPPWHDDPVYIDALATSLERHLAALDFEPEVILASFHGVPKSYLLKGDPYHCQCA
CCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEECCCCCEEHHH
KTARLLRARLDLDDKRFRLTFQSRFGRDEWLRPYTDATVKALAESGVKRLAVVNPGFVAD
HHHHHHHHHCCCCCCCEEEEEHHHCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHH
CLETLEEIGVENREIFEHHGGEKFAAIPCLNANAEGMRVLAHVVERELKGWVG
HHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TANVPAFSPDTTHLPPDHPKVAFGRIGVLIVNLGTPEATDYWSMRAYLKEFLSDPRVIE
CCCCCCCCCCCCCCCCCCCCEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
VNRAVWWFVLNAIILTKRPGPKGRDYASIWNKERNEGPLKTITRDQAEQLAAQLSGLDSR
ECHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
IVVDFAMRYGKPPIAERLAALQAQGCERILLVPLYPQYSAATSATVCDKAFDALKAMRWQ
HHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
PTLRVAPPWHDDPVYIDALATSLERHLAALDFEPEVILASFHGVPKSYLLKGDPYHCQCA
CCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEECCCCCEEHHH
KTARLLRARLDLDDKRFRLTFQSRFGRDEWLRPYTDATVKALAESGVKRLAVVNPGFVAD
HHHHHHHHHCCCCCCCEEEEEHHHCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHH
CLETLEEIGVENREIFEHHGGEKFAAIPCLNANAEGMRVLAHVVERELKGWVG
HHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA