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The map label for this gene is lrp [H]

Identifier: 154246691

GI number: 154246691

Start: 3048379

End: 3048921

Strand: Reverse

Name: lrp [H]

Synonym: Xaut_2752

Alternate gene names: 154246691

Gene position: 3048921-3048379 (Counterclockwise)

Preceding gene: 154246696

Following gene: 154246688

Centisome position: 57.43

GC content: 65.01

Gene sequence:

>543_bases
TTGCGTTGCCACAAGCGCGCACTAAGGTGCCGTGACGTTGCCGTAGGGAGTTGTGCCTTGACCGTTCGCCTTGATGCAGT
CGACTGGAAAATCCTCGACGAACTGCAACGGGATGGGCGCATGACCAATGTGGAGCTGTCCCGCCGCGTCGGCATTTCCG
CGCCGCCCTGCCTGCGCCGGGTGCGCGCGCTGGAAGAGGCCGGCATCATCGAGGGCTACCGCGCGCTGCTCGACGAAAAG
AGCCTTGGCTATGACCTCATGGCCTTCGCCATGGTGCATCTCATCAGCCAGGCCGAGGTGGACCTCGACGCCTTCCAGGA
GATGATCGCCCAATGGCCGCAGGTGCGCAGCGCCTGGATGCTCTCCGGCGACGTGGATTTCCTGATGCTGTGCGTGACCC
CGGACCTGCGCAGCTTCCAGAACCTGGTGCTGGACATCACCGCCGCGCCCAACGTGCGCAACGTGAAGACCGCCCTCACC
CTGAAGCAGTCCAAGAACGCCCCGGTGGTGCCGCTGGAAGCCGGCCTGCCCAAAGGCGCGTGA

Upstream 100 bases:

>100_bases
CGCGCCGCAGGACGGAAGGCGCGCCAACACAGCATTCGCCGACAAGGGGCGGCGCCCGCTGCGACGCTTTGGACCGCGAC
AGTGGCGCAAGATTATTTCG

Downstream 100 bases:

>100_bases
TCCAGGGGGGCGAGATCCGGGGGGCGTGAGACGACGTGTCCTGAAGCCGCCCGCAGCCCCTCCCCCGCGTGCGGGAGAGG
GTGTGAGGAGAATACGGCTC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MRCHKRALRCRDVAVGSCALTVRLDAVDWKILDELQRDGRMTNVELSRRVGISAPPCLRRVRALEEAGIIEGYRALLDEK
SLGYDLMAFAMVHLISQAEVDLDAFQEMIAQWPQVRSAWMLSGDVDFLMLCVTPDLRSFQNLVLDITAAPNVRNVKTALT
LKQSKNAPVVPLEAGLPKGA

Sequences:

>Translated_180_residues
MRCHKRALRCRDVAVGSCALTVRLDAVDWKILDELQRDGRMTNVELSRRVGISAPPCLRRVRALEEAGIIEGYRALLDEK
SLGYDLMAFAMVHLISQAEVDLDAFQEMIAQWPQVRSAWMLSGDVDFLMLCVTPDLRSFQNLVLDITAAPNVRNVKTALT
LKQSKNAPVVPLEAGLPKGA
>Mature_180_residues
MRCHKRALRCRDVAVGSCALTVRLDAVDWKILDELQRDGRMTNVELSRRVGISAPPCLRRVRALEEAGIIEGYRALLDEK
SLGYDLMAFAMVHLISQAEVDLDAFQEMIAQWPQVRSAWMLSGDVDFLMLCVTPDLRSFQNLVLDITAAPNVRNVKTALT
LKQSKNAPVVPLEAGLPKGA

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=36.551724137931, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=27.1523178807947, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 20018; Mature: 20018

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCHKRALRCRDVAVGSCALTVRLDAVDWKILDELQRDGRMTNVELSRRVGISAPPCLRR
CCCHHHHHHHHHCEECEEEEEEEECCHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHH
VRALEEAGIIEGYRALLDEKSLGYDLMAFAMVHLISQAEVDLDAFQEMIAQWPQVRSAWM
HHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHEE
LSGDVDFLMLCVTPDLRSFQNLVLDITAAPNVRNVKTALTLKQSKNAPVVPLEAGLPKGA
ECCCCEEEEEEECCCHHHHHHHEEEEECCCCCCCHHHHEEEECCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MRCHKRALRCRDVAVGSCALTVRLDAVDWKILDELQRDGRMTNVELSRRVGISAPPCLRR
CCCHHHHHHHHHCEECEEEEEEEECCHHHHHHHHHHHCCCCCCEEHHHHCCCCCCHHHHH
VRALEEAGIIEGYRALLDEKSLGYDLMAFAMVHLISQAEVDLDAFQEMIAQWPQVRSAWM
HHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHEE
LSGDVDFLMLCVTPDLRSFQNLVLDITAAPNVRNVKTALTLKQSKNAPVVPLEAGLPKGA
ECCCCEEEEEEECCCHHHHHHHEEEEECCCCCCCHHHHEEEECCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]