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The map label for this gene is msrA [H]

Identifier: 154246435

GI number: 154246435

Start: 2785731

End: 2786387

Strand: Reverse

Name: msrA [H]

Synonym: Xaut_2494

Alternate gene names: 154246435

Gene position: 2786387-2785731 (Counterclockwise)

Preceding gene: 154246438

Following gene: 154246434

Centisome position: 52.48

GC content: 67.73

Gene sequence:

>657_bases
ATGTTCTGGCTGAAGAAGTCCCTCGACCTGCCCACCAAGGCTGACGCACTGCCCGGCCGCAGCACGCCCGTGCCCACCGC
CGAGACCCATTTCGTCAACGGCCATGCCCTCAAGGGCCCCTACCCCGCCGGGTTCGAGACCGCGGTGTTCGCCCTCGGCT
GCTTCTGGGGCGCCGAGCGCAAGTTCTGGCAGACCCCCGGCGTGTGGGCCACCGCTGTCGGCTATGTGGCCGGCATCACC
GAGAACCCCACTTACGAGGAGGTGTGCTCCGGCCGTACCGGGCATACCGAGGCGGTGCTGGTGGTCTATGATCCCAAGGC
CGTGAGCTATGACGAGCTGGTGCGCCTGTTCTTCGAATCCCACGACCCCACCCAGGGCATGCGCCAGGGCAATGACGTGG
GCACCCAGTACCGCTCCGGCATCTATGTGACCAATGCCGGCCAGCGGGTGGCGGCGGAAGCGGCCAAGGCCGCCTACGAG
CCGGCGCTGAAGGCCAAGGGCTTTGGGCCGATCACCACCGAGATCGCGGAGCTGGGGCCGTTCTATTTCGCGGAAGGCTA
CCACCAGCAGTATCTGGCCAAGAACCCCGCCGGCTATTGTGGCCTCGGCGGCACCGGCGTCTCCTGCCCCATCGGCACCG
GAGTCGCGGCGCAGTAG

Upstream 100 bases:

>100_bases
TTGGGGATCCGGCCCGGCTTGCCGCCGGCGCTTTCCTTCAAGCCCCATTCGCGCGCGACGGGTCCGATGCCCGGCGCGGC
GCCCCCGCGAGGAGCCCGCC

Downstream 100 bases:

>100_bases
CCTCCCGGCACGACAGGAGCACACTTTTCAGGCAGGGCGCGGCGCAGGCTGCGCCCTGCTTCGTTTCGGCCCCCTGTTGC
AAAGGCGGGCGCCGCGCGGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFWLKKSLDLPTKADALPGRSTPVPTAETHFVNGHALKGPYPAGFETAVFALGCFWGAERKFWQTPGVWATAVGYVAGIT
ENPTYEEVCSGRTGHTEAVLVVYDPKAVSYDELVRLFFESHDPTQGMRQGNDVGTQYRSGIYVTNAGQRVAAEAAKAAYE
PALKAKGFGPITTEIAELGPFYFAEGYHQQYLAKNPAGYCGLGGTGVSCPIGTGVAAQ

Sequences:

>Translated_218_residues
MFWLKKSLDLPTKADALPGRSTPVPTAETHFVNGHALKGPYPAGFETAVFALGCFWGAERKFWQTPGVWATAVGYVAGIT
ENPTYEEVCSGRTGHTEAVLVVYDPKAVSYDELVRLFFESHDPTQGMRQGNDVGTQYRSGIYVTNAGQRVAAEAAKAAYE
PALKAKGFGPITTEIAELGPFYFAEGYHQQYLAKNPAGYCGLGGTGVSCPIGTGVAAQ
>Mature_218_residues
MFWLKKSLDLPTKADALPGRSTPVPTAETHFVNGHALKGPYPAGFETAVFALGCFWGAERKFWQTPGVWATAVGYVAGIT
ENPTYEEVCSGRTGHTEAVLVVYDPKAVSYDELVRLFFESHDPTQGMRQGNDVGTQYRSGIYVTNAGQRVAAEAAKAAYE
PALKAKGFGPITTEIAELGPFYFAEGYHQQYLAKNPAGYCGLGGTGVSCPIGTGVAAQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=59.3137254901961, Blast_Score=261, Evalue=3e-70,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=62.2950819672131, Blast_Score=247, Evalue=7e-66,
Organism=Homo sapiens, GI208609993, Length=204, Percent_Identity=46.5686274509804, Blast_Score=184, Evalue=7e-47,
Organism=Escherichia coli, GI1790665, Length=193, Percent_Identity=59.0673575129534, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=37.3333333333333, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=37.3493975903614, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=40, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=39.3103448275862, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=39.2857142857143, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23308; Mature: 23308

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFWLKKSLDLPTKADALPGRSTPVPTAETHFVNGHALKGPYPAGFETAVFALGCFWGAER
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
KFWQTPGVWATAVGYVAGITENPTYEEVCSGRTGHTEAVLVVYDPKAVSYDELVRLFFES
CEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHC
HDPTQGMRQGNDVGTQYRSGIYVTNAGQRVAAEAAKAAYEPALKAKGFGPITTEIAELGP
CCCHHHHHCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
FYFAEGYHQQYLAKNPAGYCGLGGTGVSCPIGTGVAAQ
HHHHCCHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFWLKKSLDLPTKADALPGRSTPVPTAETHFVNGHALKGPYPAGFETAVFALGCFWGAER
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
KFWQTPGVWATAVGYVAGITENPTYEEVCSGRTGHTEAVLVVYDPKAVSYDELVRLFFES
CEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHC
HDPTQGMRQGNDVGTQYRSGIYVTNAGQRVAAEAAKAAYEPALKAKGFGPITTEIAELGP
CCCHHHHHCCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
FYFAEGYHQQYLAKNPAGYCGLGGTGVSCPIGTGVAAQ
HHHHCCHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA