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The map label for this gene is folP [C]

Identifier: 154246434

GI number: 154246434

Start: 2784749

End: 2785189

Strand: Reverse

Name: folP [C]

Synonym: Xaut_2493

Alternate gene names: 154246434

Gene position: 2785189-2784749 (Counterclockwise)

Preceding gene: 154246435

Following gene: 154246433

Centisome position: 52.46

GC content: 65.31

Gene sequence:

>441_bases
ATGGCCAAAGTGGTGGCGGAGTACGACGCCGCCGCTGTCATCATGCATAACCGAACCGAAGTCGATGAATCCCTCGATAT
CGTCGCCGATATGCTGGACTTCTTCGCGAAAGCTCTCGATACGGCCGACAAGGCGGGCGTGAAGCGCGAGCGTCTGGTGC
TCGACCCCGGCATCGGCTTCGGCAAGAGCTTCCCGCAGAACCTCTCCGCCATCCGCCGCCTCGGCGAGCTCCGCGTGCTG
GGACTGCCGATCCTGCTCGGCGCGTCGCGCAAGTCCTTGATCGGAAAGGTGATTGATACCGTGCCGGCGGAACGCCTGCC
GGGCACCATCGCCTCCAACGTCATCGCCATCATGGCCGGGGTGGAGATCATCCGGGTGCATGACGTAGCCGCCCATGTGC
AGGCGGCGCGCGTCGCCGAGGCCATCCGGGACGCCTCGTGA

Upstream 100 bases:

>100_bases
GATCTCGGTGGACACTTACAAGGCCTCGGTCGCGCGGCGGGCGCTGGAGGCGGGGGCGGTGATCGTCAACGACGTGTGGG
GCTTTTCCCGCGATCCGGAC

Downstream 100 bases:

>100_bases
CCAGCCGCACCGCCTATCTGTGCCTGGGGTCCAACGTGGGCGACCGGGCCGCCACCATGAGGCTGGCGCTGGGTGTGCTG
GCCCGCGCCGGCCTCACCAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MAKVVAEYDAAAVIMHNRTEVDESLDIVADMLDFFAKALDTADKAGVKRERLVLDPGIGFGKSFPQNLSAIRRLGELRVL
GLPILLGASRKSLIGKVIDTVPAERLPGTIASNVIAIMAGVEIIRVHDVAAHVQAARVAEAIRDAS

Sequences:

>Translated_146_residues
MAKVVAEYDAAAVIMHNRTEVDESLDIVADMLDFFAKALDTADKAGVKRERLVLDPGIGFGKSFPQNLSAIRRLGELRVL
GLPILLGASRKSLIGKVIDTVPAERLPGTIASNVIAIMAGVEIIRVHDVAAHVQAARVAEAIRDAS
>Mature_145_residues
AKVVAEYDAAAVIMHNRTEVDESLDIVADMLDFFAKALDTADKAGVKRERLVLDPGIGFGKSFPQNLSAIRRLGELRVLG
LPILLGASRKSLIGKVIDTVPAERLPGTIASNVIAIMAGVEIIRVHDVAAHVQAARVAEAIRDAS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=120, Percent_Identity=45.8333333333333, Blast_Score=117, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324073, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 15565; Mature: 15434

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVVAEYDAAAVIMHNRTEVDESLDIVADMLDFFAKALDTADKAGVKRERLVLDPGIGF
CCCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEECCCCCC
GKSFPQNLSAIRRLGELRVLGLPILLGASRKSLIGKVIDTVPAERLPGTIASNVIAIMAG
CCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHH
VEIIRVHDVAAHVQAARVAEAIRDAS
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKVVAEYDAAAVIMHNRTEVDESLDIVADMLDFFAKALDTADKAGVKRERLVLDPGIGF
CCHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEECCCCCC
GKSFPQNLSAIRRLGELRVLGLPILLGASRKSLIGKVIDTVPAERLPGTIASNVIAIMAG
CCCCHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHH
VEIIRVHDVAAHVQAARVAEAIRDAS
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]