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The map label for this gene is folK [H]

Identifier: 154246433

GI number: 154246433

Start: 2784261

End: 2784752

Strand: Reverse

Name: folK [H]

Synonym: Xaut_2492

Alternate gene names: 154246433

Gene position: 2784752-2784261 (Counterclockwise)

Preceding gene: 154246434

Following gene: 154246431

Centisome position: 52.45

GC content: 69.92

Gene sequence:

>492_bases
GTGACCAGCCGCACCGCCTATCTGTGCCTGGGGTCCAACGTGGGCGACCGGGCCGCCACCATGAGGCTGGCGCTGGGTGT
GCTGGCCCGCGCCGGCCTCACCATCGGCGCCCGCTCCTCGCTCTATGAGACGCCGCCCTGGGGGCCGATCCCGCAGGGGC
CTTACCTCAATCAAGTGGTTGAAATCCAAAGCCCGGTGCCGCCCCGCAGCCTGCTGTTCCTGGCCCTTGCGGTGGAGCGC
ATGCTGGGGCGCGACCGGCCCCACGAGGTGCGCTTCGGGCCCCGCCGCATCGACATCGATATCCTGTTGTTCGCAAACGA
GACGATCGCCGAGCCGGACCTGGAGATCCCGCATCCCCGCCTGCTTGAGCGCGCCTTCGCCCTGGTCCCCCTGACCGAGA
TCGCGCCGGACATCGTGGTCTCAGGGGTGCGCGCGGCGGATGCGCTGGCGGCGCTCGACAAGAGCGGCATCGAGAAGGTC
GCAGTCGCTTGA

Upstream 100 bases:

>100_bases
ACGTCATCGCCATCATGGCCGGGGTGGAGATCATCCGGGTGCATGACGTAGCCGCCCATGTGCAGGCGGCGCGCGTCGCC
GAGGCCATCCGGGACGCCTC

Downstream 100 bases:

>100_bases
AAACGCACAAAAAGCCCCGCGCCGGGTGGCGCGGGGCGGGTCGGACAGGTCCGCGATCACATGGTGCGGATGTTGGTGGA
CCAGGTATCCACCTGGCGCT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MTSRTAYLCLGSNVGDRAATMRLALGVLARAGLTIGARSSLYETPPWGPIPQGPYLNQVVEIQSPVPPRSLLFLALAVER
MLGRDRPHEVRFGPRRIDIDILLFANETIAEPDLEIPHPRLLERAFALVPLTEIAPDIVVSGVRAADALAALDKSGIEKV
AVA

Sequences:

>Translated_163_residues
MTSRTAYLCLGSNVGDRAATMRLALGVLARAGLTIGARSSLYETPPWGPIPQGPYLNQVVEIQSPVPPRSLLFLALAVER
MLGRDRPHEVRFGPRRIDIDILLFANETIAEPDLEIPHPRLLERAFALVPLTEIAPDIVVSGVRAADALAALDKSGIEKV
AVA
>Mature_162_residues
TSRTAYLCLGSNVGDRAATMRLALGVLARAGLTIGARSSLYETPPWGPIPQGPYLNQVVEIQSPVPPRSLLFLALAVERM
LGRDRPHEVRFGPRRIDIDILLFANETIAEPDLEIPHPRLLERAFALVPLTEIAPDIVVSGVRAADALAALDKSGIEKVA
VA

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=40.7407407407407, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324073, Length=151, Percent_Identity=38.4105960264901, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17596; Mature: 17465

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRTAYLCLGSNVGDRAATMRLALGVLARAGLTIGARSSLYETPPWGPIPQGPYLNQVV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHE
EIQSPVPPRSLLFLALAVERMLGRDRPHEVRFGPRRIDIDILLFANETIAEPDLEIPHPR
ECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCHH
LLERAFALVPLTEIAPDIVVSGVRAADALAALDKSGIEKVAVA
HHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
TSRTAYLCLGSNVGDRAATMRLALGVLARAGLTIGARSSLYETPPWGPIPQGPYLNQVV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHE
EIQSPVPPRSLLFLALAVERMLGRDRPHEVRFGPRRIDIDILLFANETIAEPDLEIPHPR
ECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCHH
LLERAFALVPLTEIAPDIVVSGVRAADALAALDKSGIEKVAVA
HHHHHHHHHCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]