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The map label for this gene is gntR [H]

Identifier: 154246375

GI number: 154246375

Start: 2721293

End: 2722441

Strand: Reverse

Name: gntR [H]

Synonym: Xaut_2434

Alternate gene names: 154246375

Gene position: 2722441-2721293 (Counterclockwise)

Preceding gene: 154246376

Following gene: 154246374

Centisome position: 51.28

GC content: 71.37

Gene sequence:

>1149_bases
ATGTCCCGACCAACCCAGAAGCCCACCATGCGGGATGTCTCGCGCCTCGCGCGGGTCTCCCCCATGACCGTTTCGCGGGT
GTTCACCGATCCGGACACGGTGGCCGCGCCCACCCGCGAGCGGGTGCTGAAAGCGGTGGAGCAGCTCGGCTACCTGCCGG
ACCTGGTGGCCGGGGCCCTGTCCTCGCGGCGCACCAATTTCGTTGGGCTGATCCTGCCGACCCTGACCAACTCCAATTTC
GGCGACACTGCCCAGGGCCTCGCGGAAGTGCTGAAGGCCGACGCCACTCAGCTCCTCATCGGCTACACCCTCTATCAGGT
GGCCGAGGAAGAGCGCCTCGTGCGCGCGCTGCTGCCCCGCCGCCCGGACGCCATCGTCATCGCCGGCTCGGTGCACACGG
CCGCGACCCGCACCCTGCTCGACCGCGCCGGCATTCCGGTGGTGGAGATCTGGGAGCAGCCGGACCAGCCCCTCGACCGC
GCCGTGGGCTTCTCCAATTTCGAGGTGGGGCGCGCCGCCGCCCGCCATCTCATCGCGCTCGGCCACCGCAAGATCGGCGC
CATCGGGCCGGAGGCCGACGCGGACCTGTGCGACCATCGCGCCGACACCCGCCTGAAGGGCTTTTCCTCCATGCTGCGCG
AGGCCGGACTCTCCGACGCTTTGGTGCTGCGCCACGGACTGCCGCCGGCCTCCTTCGAGCACGGCGCCAACGCCATCGGC
GCGCTGCTCGCGCGGGCGCCGGACGTGGAGGCGGTGTTCGCCGTGTCCGACCTCGCAGCCTTCGGCGCGATGATGGAGCT
GAAGCGGCGCGGCATCGACGTTCCAGGGCAGATCTCCCTGATCGGCTTCGGCAATTTCGAGGTGGGCCGCCTCAGCTATC
CGGCCATGACCACCATCGGGGTGGATGCCCGCGCCATCGGCGCCGCCGCCGGCACCATGCTGCGCGCCCTGCTGAAGCGC
GACGCGCAGGAAGCCGAGGTGGAGCGCAACGTGGACGTGGGCTTCACCCTGATCGAACGCGAAACCACCGCCCCGCGCCC
CGCCGCACCGGCGAAGGCACGCAAACGCCCGACCGCCGCCGCGGCCGGCAACCAACCAAAGACCGCTGCCGGCCCCCGCC
GCACGCAGGCCGCGAGGGAAACGCCATGA

Upstream 100 bases:

>100_bases
TTCCTGGCTCACCTGAATAAAATGCGAAAATCCAAGTAGAAATACAGATCCAGCGCGCCCCCGCGCGGGATCTGCCCCGG
CAGGAGAGCGGACCCAAGCC

Downstream 100 bases:

>100_bases
CACAGGTGCACAAGCCCGACGTCGCAGTCATCGGCGCCGGCATCATGGGCAGCGCCATCGCCCAGCGCCTGCTGGACACC
GGCCATGGCGTCCATGTGTT

Product: periplasmic binding protein/LacI transcriptional regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSRPTQKPTMRDVSRLARVSPMTVSRVFTDPDTVAAPTRERVLKAVEQLGYLPDLVAGALSSRRTNFVGLILPTLTNSNF
GDTAQGLAEVLKADATQLLIGYTLYQVAEEERLVRALLPRRPDAIVIAGSVHTAATRTLLDRAGIPVVEIWEQPDQPLDR
AVGFSNFEVGRAAARHLIALGHRKIGAIGPEADADLCDHRADTRLKGFSSMLREAGLSDALVLRHGLPPASFEHGANAIG
ALLARAPDVEAVFAVSDLAAFGAMMELKRRGIDVPGQISLIGFGNFEVGRLSYPAMTTIGVDARAIGAAAGTMLRALLKR
DAQEAEVERNVDVGFTLIERETTAPRPAAPAKARKRPTAAAAGNQPKTAAGPRRTQAARETP

Sequences:

>Translated_382_residues
MSRPTQKPTMRDVSRLARVSPMTVSRVFTDPDTVAAPTRERVLKAVEQLGYLPDLVAGALSSRRTNFVGLILPTLTNSNF
GDTAQGLAEVLKADATQLLIGYTLYQVAEEERLVRALLPRRPDAIVIAGSVHTAATRTLLDRAGIPVVEIWEQPDQPLDR
AVGFSNFEVGRAAARHLIALGHRKIGAIGPEADADLCDHRADTRLKGFSSMLREAGLSDALVLRHGLPPASFEHGANAIG
ALLARAPDVEAVFAVSDLAAFGAMMELKRRGIDVPGQISLIGFGNFEVGRLSYPAMTTIGVDARAIGAAAGTMLRALLKR
DAQEAEVERNVDVGFTLIERETTAPRPAAPAKARKRPTAAAAGNQPKTAAGPRRTQAARETP
>Mature_381_residues
SRPTQKPTMRDVSRLARVSPMTVSRVFTDPDTVAAPTRERVLKAVEQLGYLPDLVAGALSSRRTNFVGLILPTLTNSNFG
DTAQGLAEVLKADATQLLIGYTLYQVAEEERLVRALLPRRPDAIVIAGSVHTAATRTLLDRAGIPVVEIWEQPDQPLDRA
VGFSNFEVGRAAARHLIALGHRKIGAIGPEADADLCDHRADTRLKGFSSMLREAGLSDALVLRHGLPPASFEHGANAIGA
LLARAPDVEAVFAVSDLAAFGAMMELKRRGIDVPGQISLIGFGNFEVGRLSYPAMTTIGVDARAIGAAAGTMLRALLKRD
AQEAEVERNVDVGFTLIERETTAPRPAAPAKARKRPTAAAAGNQPKTAAGPRRTQAARETP

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=332, Percent_Identity=29.5180722891566, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1790715, Length=351, Percent_Identity=30.1994301994302, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790369, Length=309, Percent_Identity=31.7152103559871, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787948, Length=344, Percent_Identity=29.0697674418605, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788474, Length=309, Percent_Identity=31.0679611650485, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789202, Length=293, Percent_Identity=33.1058020477816, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789068, Length=298, Percent_Identity=29.5302013422819, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790194, Length=337, Percent_Identity=26.1127596439169, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=26.4797507788162, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786540, Length=358, Percent_Identity=27.6536312849162, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787906, Length=275, Percent_Identity=30.1818181818182, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 40763; Mature: 40632

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPTQKPTMRDVSRLARVSPMTVSRVFTDPDTVAAPTRERVLKAVEQLGYLPDLVAGAL
CCCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SSRRTNFVGLILPTLTNSNFGDTAQGLAEVLKADATQLLIGYTLYQVAEEERLVRALLPR
HHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPDAIVIAGSVHTAATRTLLDRAGIPVVEIWEQPDQPLDRAVGFSNFEVGRAAARHLIAL
CCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
GHRKIGAIGPEADADLCDHRADTRLKGFSSMLREAGLSDALVLRHGLPPASFEHGANAIG
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHH
ALLARAPDVEAVFAVSDLAAFGAMMELKRRGIDVPGQISLIGFGNFEVGRLSYPAMTTIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEC
VDARAIGAAAGTMLRALLKRDAQEAEVERNVDVGFTLIERETTAPRPAAPAKARKRPTAA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHH
AAGNQPKTAAGPRRTQAARETP
CCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SRPTQKPTMRDVSRLARVSPMTVSRVFTDPDTVAAPTRERVLKAVEQLGYLPDLVAGAL
CCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SSRRTNFVGLILPTLTNSNFGDTAQGLAEVLKADATQLLIGYTLYQVAEEERLVRALLPR
HHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RPDAIVIAGSVHTAATRTLLDRAGIPVVEIWEQPDQPLDRAVGFSNFEVGRAAARHLIAL
CCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
GHRKIGAIGPEADADLCDHRADTRLKGFSSMLREAGLSDALVLRHGLPPASFEHGANAIG
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHH
ALLARAPDVEAVFAVSDLAAFGAMMELKRRGIDVPGQISLIGFGNFEVGRLSYPAMTTIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEEC
VDARAIGAAAGTMLRALLKRDAQEAEVERNVDVGFTLIERETTAPRPAAPAKARKRPTAA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHH
AAGNQPKTAAGPRRTQAARETP
CCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]