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The map label for this gene is garR [H]

Identifier: 154246374

GI number: 154246374

Start: 2720409

End: 2721296

Strand: Reverse

Name: garR [H]

Synonym: Xaut_2433

Alternate gene names: 154246374

Gene position: 2721296-2720409 (Counterclockwise)

Preceding gene: 154246375

Following gene: 154246373

Centisome position: 51.26

GC content: 71.85

Gene sequence:

>888_bases
ATGACACAGGTGCACAAGCCCGACGTCGCAGTCATCGGCGCCGGCATCATGGGCAGCGCCATCGCCCAGCGCCTGCTGGA
CACCGGCCATGGCGTCCATGTGTTCGACATCGATGCCGCCCGCGTGGCGGCGCTTGCGGCCAAGGGCGCCACCGGCCACG
CCAGCGTCGCGGCGGCGGCGGGCGCGGCGCCTTTCGTCATCCTCAGCCTGAACCGCGCCGACATCGTGGAAGCGGCGGTG
TTCGGACCGGACGGCGTCGCCTGCGTGGCCGCGCCGGAGCGGATGGTGATCGACATGTCGTCCATCGACCCCGGCGCCAC
CAAGCGCGTGGCCGAGCGGCTGAAGCGCGAGACCGGCATGGCCTTCGTGGATTGCCCGCTCTCCGGTGGCGTGCCCGGCG
CCCTTGAGGGCCGGCTGACGGTGATGGCGGGGGGCGAGCCCGACCATGTGGAGCGCGCCCGCGCGGTGATGGACGATCTT
TGCGCCAACTACACCCGCATGGGCGGTCCCGGCGCCGGGCAGACCACCAAGCTCGTCAACCAGCTGTTCTGCGCGGTGCT
GTTCCAGGCCGTGGCGGAGGCGGTGAAGCTGGCCGAGGCCGGCGGCGTCGACCCCGCCGCCATTCCCGTGGCCCTGAGCG
GCGGACGGGCCGATTCGCGCATCCTCGGCGAGTTCATGGCCAAGTTCGCGGCGCGCGACTTCACCCCCACCGGCCGCATC
GAGAACATGCTGAAGGACCTGGAATCCGTGCAGGCCTTCGCCATGGCCACCCGCACCCCGCTGCCCATGACCTCCCTGGT
GACCGAGATCCACCGCCTCCTGCAGGCCTCGGGCCTCGGCGGCCGCGACACCGCCGAAATGATGCGCCTGCTCGACGGCA
CGGCGTAG

Upstream 100 bases:

>100_bases
CACCGGCGAAGGCACGCAAACGCCCGACCGCCGCCGCGGCCGGCAACCAACCAAAGACCGCTGCCGGCCCCCGCCGCACG
CAGGCCGCGAGGGAAACGCC

Downstream 100 bases:

>100_bases
GCCCCCGGCCAGCCGTCCCAGCCCCTTCACAGCCGAAACTTCCCCTGGGACACCCCCTCGGGATACCGTACCACGCGGGG
GTGTCACGATCTGGCATAAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTQVHKPDVAVIGAGIMGSAIAQRLLDTGHGVHVFDIDAARVAALAAKGATGHASVAAAAGAAPFVILSLNRADIVEAAV
FGPDGVACVAAPERMVIDMSSIDPGATKRVAERLKRETGMAFVDCPLSGGVPGALEGRLTVMAGGEPDHVERARAVMDDL
CANYTRMGGPGAGQTTKLVNQLFCAVLFQAVAEAVKLAEAGGVDPAAIPVALSGGRADSRILGEFMAKFAARDFTPTGRI
ENMLKDLESVQAFAMATRTPLPMTSLVTEIHRLLQASGLGGRDTAEMMRLLDGTA

Sequences:

>Translated_295_residues
MTQVHKPDVAVIGAGIMGSAIAQRLLDTGHGVHVFDIDAARVAALAAKGATGHASVAAAAGAAPFVILSLNRADIVEAAV
FGPDGVACVAAPERMVIDMSSIDPGATKRVAERLKRETGMAFVDCPLSGGVPGALEGRLTVMAGGEPDHVERARAVMDDL
CANYTRMGGPGAGQTTKLVNQLFCAVLFQAVAEAVKLAEAGGVDPAAIPVALSGGRADSRILGEFMAKFAARDFTPTGRI
ENMLKDLESVQAFAMATRTPLPMTSLVTEIHRLLQASGLGGRDTAEMMRLLDGTA
>Mature_294_residues
TQVHKPDVAVIGAGIMGSAIAQRLLDTGHGVHVFDIDAARVAALAAKGATGHASVAAAAGAAPFVILSLNRADIVEAAVF
GPDGVACVAAPERMVIDMSSIDPGATKRVAERLKRETGMAFVDCPLSGGVPGALEGRLTVMAGGEPDHVERARAVMDDLC
ANYTRMGGPGAGQTTKLVNQLFCAVLFQAVAEAVKLAEAGGVDPAAIPVALSGGRADSRILGEFMAKFAARDFTPTGRIE
NMLKDLESVQAFAMATRTPLPMTSLVTEIHRLLQASGLGGRDTAEMMRLLDGTA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=28.3276450511945, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=22.4199288256228, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI145693186, Length=275, Percent_Identity=34.1818181818182, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786719, Length=281, Percent_Identity=34.1637010676157, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=32.280701754386, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=28.4722222222222, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=285, Percent_Identity=30.8771929824561, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24655230, Length=299, Percent_Identity=32.7759197324415, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922568, Length=299, Percent_Identity=32.7759197324415, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574115, Length=275, Percent_Identity=24.7272727272727, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30372; Mature: 30241

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVHKPDVAVIGAGIMGSAIAQRLLDTGHGVHVFDIDAARVAALAAKGATGHASVAAAA
CCCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHHC
GAAPFVILSLNRADIVEAAVFGPDGVACVAAPERMVIDMSSIDPGATKRVAERLKRETGM
CCCCEEEEECCHHHHHHHHEECCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCC
AFVDCPLSGGVPGALEGRLTVMAGGEPDHVERARAVMDDLCANYTRMGGPGAGQTTKLVN
EEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QLFCAVLFQAVAEAVKLAEAGGVDPAAIPVALSGGRADSRILGEFMAKFAARDFTPTGRI
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHH
ENMLKDLESVQAFAMATRTPLPMTSLVTEIHRLLQASGLGGRDTAEMMRLLDGTA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TQVHKPDVAVIGAGIMGSAIAQRLLDTGHGVHVFDIDAARVAALAAKGATGHASVAAAA
CCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHHC
GAAPFVILSLNRADIVEAAVFGPDGVACVAAPERMVIDMSSIDPGATKRVAERLKRETGM
CCCCEEEEECCHHHHHHHHEECCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCC
AFVDCPLSGGVPGALEGRLTVMAGGEPDHVERARAVMDDLCANYTRMGGPGAGQTTKLVN
EEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
QLFCAVLFQAVAEAVKLAEAGGVDPAAIPVALSGGRADSRILGEFMAKFAARDFTPTGRI
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHH
ENMLKDLESVQAFAMATRTPLPMTSLVTEIHRLLQASGLGGRDTAEMMRLLDGTA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]