| Definition | Xanthobacter autotrophicus Py2 chromosome, complete genome. |
|---|---|
| Accession | NC_009720 |
| Length | 5,308,934 |
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The map label for this gene is cysG [H]
Identifier: 154246317
GI number: 154246317
Start: 2651788
End: 2653311
Strand: Reverse
Name: cysG [H]
Synonym: Xaut_2375
Alternate gene names: 154246317
Gene position: 2653311-2651788 (Counterclockwise)
Preceding gene: 154246318
Following gene: 154246315
Centisome position: 49.98
GC content: 73.36
Gene sequence:
>1524_bases ATGGCCGCCACCGGCCCCGACACCCCCAACTCCGGCGCCCTGTCGCCCCGCGCCCCGCGCCAGGCCGGACATGCGCGCAT GGAGGCCCTCGCGCGCCTGCCGGTGTTCTTTGGCCTGGAGGGCCGGCGCGTGCTGGTGGCGGGCGGCGGCGAGCCGGCGG CCTGGAAGGCGGAACTGCTCTCCGCCGCCGGGGCGCGGGTGGAGGTGATCGCCCCCCATGTCTGCGAGGACCTGTGGCGG CTGGCCGGCGCGCCGCCCCGTGGACCCATCTCGATCCATGTGCGCGACTGGCACGCCGACGACATCCCCGGCGCCGTCCT CGCGGTGGCCGGCTTTGACGAAGAGGCGGACGCCCTCAACTTCACCACCGCCGCCCGCGCTGCCGGCGTGCCGGTGAACG CCATCGACAAGCCGGCCCTCTCCGACTTCACCTTCGGCGCCATCGTGAACCGCTCGCCGCTGGTGGTGGGCATCTCCACC GACGGCGCGGCGCCCGTCTTCGGGCAGGCGGTGCGGGCCAAGATCGAGGCGCTGTTGCCCTCGGGCTTCAAGGCCTGGGC GCTGGCCGCAAAGACGTGGCGGCAGGCGGTGACCGCGCGCGGCCTCTCCCACCACGCCCGCCGCGCCTTCTGGGAACGCT TCGCCGCCACGGCGCTGGCCGAGCCCAACCGGGCGCCGCAGGACACCGACCGCGCCGCCCTGTTCACCGCCATCGAGGCG GAGGGCACGCCGCACCGCTCCGGCCACGCGGGCTCGGTGGTGCTGGTGGGCGCAGGCCCCGGCGATCCGGAGCTGCTCAC GCTCAAGGCGGTGCGGGCGCTGCAATCGGCGGACGTGGTGCTCTATGACGACCTCGTCTCCGGCGCGATCCTCGATTTCG CCCGGCGCGAGGCGAAGAAGATGCTGGTGGGCAAGACCGGCTACGGCCCCTCCTGCAAGCAGGACGACATCAACGCTTTG ATGGTGGACCTCGCCAAGGAAGGCCGCCGCGTGGTGCGCCTGAAGGGCGGCGAGCCCATGATCTTCGGCCGCGCCGGGGA AGAGATCACCCATTGCCATGCGGCGGGGGTGCCGGTGGAGGTGATCCCCGGCATCTCGGCACCGCAGGGGGCGGCGAGCC GGCTGGTCACCTCGCTCACCCACCGCGACCATGCACGGCGGCTGCAATTCGTCACCGCCCATGCTCGCGACGGCAAGCTG CCCAAGGACCTCGACTTCAACGCGCTGGCCGACAAGGCGGCGACGACGGTGGTCTACATGCCCCGCCGCACCCTGCCGGA CCTGGTGCGCAACCTGATGGCCGCGGGCATCGATCCGGCGACGCCCGCGGTGGCCATGTTCTCGGTGACGCGGCCGGAGG AGAAGGTGATCCTCGCCACCGTCGCGACGCTGGCGGAAGAGGTGGCCCGCGCCGCCGAGGTGGGCGCGCAAGGCCCCTGC CTCATCCTCTACGGCCAGGCCCTGGCCGAAGTGGCGGTGGATGCCCTGCCCCAGATCGTCCAGGCTGCCGCCAACGGCGG CTGA
Upstream 100 bases:
>100_bases GCGGCGCCCCGCGCGTCCGCCGGAGGGCCGCAGCCGCGTTGATCGGCGGACCGGCACGCCTTACGTTGAAGATCCAACAG TTTCGGGAGCACCTTTCCCC
Downstream 100 bases:
>100_bases GGGGCGAATCCCGACGCCAGCCCGCGTTGCCCCCTTCAGGAATACGTCCCAAACACACTCTCGTCATGCCCCGGCTTGAC CGGGGCATCCACGCCGCCGG
Product: uroporphyrin-III C-methyltransferase
Products: NA
Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]
Number of amino acids: Translated: 507; Mature: 506
Protein sequence:
>507_residues MAATGPDTPNSGALSPRAPRQAGHARMEALARLPVFFGLEGRRVLVAGGGEPAAWKAELLSAAGARVEVIAPHVCEDLWR LAGAPPRGPISIHVRDWHADDIPGAVLAVAGFDEEADALNFTTAARAAGVPVNAIDKPALSDFTFGAIVNRSPLVVGIST DGAAPVFGQAVRAKIEALLPSGFKAWALAAKTWRQAVTARGLSHHARRAFWERFAATALAEPNRAPQDTDRAALFTAIEA EGTPHRSGHAGSVVLVGAGPGDPELLTLKAVRALQSADVVLYDDLVSGAILDFARREAKKMLVGKTGYGPSCKQDDINAL MVDLAKEGRRVVRLKGGEPMIFGRAGEEITHCHAAGVPVEVIPGISAPQGAASRLVTSLTHRDHARRLQFVTAHARDGKL PKDLDFNALADKAATTVVYMPRRTLPDLVRNLMAAGIDPATPAVAMFSVTRPEEKVILATVATLAEEVARAAEVGAQGPC LILYGQALAEVAVDALPQIVQAAANGG
Sequences:
>Translated_507_residues MAATGPDTPNSGALSPRAPRQAGHARMEALARLPVFFGLEGRRVLVAGGGEPAAWKAELLSAAGARVEVIAPHVCEDLWR LAGAPPRGPISIHVRDWHADDIPGAVLAVAGFDEEADALNFTTAARAAGVPVNAIDKPALSDFTFGAIVNRSPLVVGIST DGAAPVFGQAVRAKIEALLPSGFKAWALAAKTWRQAVTARGLSHHARRAFWERFAATALAEPNRAPQDTDRAALFTAIEA EGTPHRSGHAGSVVLVGAGPGDPELLTLKAVRALQSADVVLYDDLVSGAILDFARREAKKMLVGKTGYGPSCKQDDINAL MVDLAKEGRRVVRLKGGEPMIFGRAGEEITHCHAAGVPVEVIPGISAPQGAASRLVTSLTHRDHARRLQFVTAHARDGKL PKDLDFNALADKAATTVVYMPRRTLPDLVRNLMAAGIDPATPAVAMFSVTRPEEKVILATVATLAEEVARAAEVGAQGPC LILYGQALAEVAVDALPQIVQAAANGG >Mature_506_residues AATGPDTPNSGALSPRAPRQAGHARMEALARLPVFFGLEGRRVLVAGGGEPAAWKAELLSAAGARVEVIAPHVCEDLWRL AGAPPRGPISIHVRDWHADDIPGAVLAVAGFDEEADALNFTTAARAAGVPVNAIDKPALSDFTFGAIVNRSPLVVGISTD GAAPVFGQAVRAKIEALLPSGFKAWALAAKTWRQAVTARGLSHHARRAFWERFAATALAEPNRAPQDTDRAALFTAIEAE GTPHRSGHAGSVVLVGAGPGDPELLTLKAVRALQSADVVLYDDLVSGAILDFARREAKKMLVGKTGYGPSCKQDDINALM VDLAKEGRRVVRLKGGEPMIFGRAGEEITHCHAAGVPVEVIPGISAPQGAASRLVTSLTHRDHARRLQFVTAHARDGKLP KDLDFNALADKAATTVVYMPRRTLPDLVRNLMAAGIDPATPAVAMFSVTRPEEKVILATVATLAEEVARAAEVGAQGPCL ILYGQALAEVAVDALPQIVQAAANGG
Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si
COG id: COG0007
COG function: function code H; Uroporphyrinogen-III methylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the precorrin methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1789768, Length=466, Percent_Identity=35.1931330472103, Blast_Score=242, Evalue=5e-65, Organism=Saccharomyces cerevisiae, GI6322922, Length=238, Percent_Identity=31.0924369747899, Blast_Score=98, Evalue=3e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000878 - InterPro: IPR014777 - InterPro: IPR014776 - InterPro: IPR006366 - InterPro: IPR016040 - InterPro: IPR019478 - InterPro: IPR006367 - InterPro: IPR003043 [H]
Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]
EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]
Molecular weight: Translated: 53051; Mature: 52920
Theoretical pI: Translated: 7.73; Mature: 7.73
Prosite motif: PS00839 SUMT_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAATGPDTPNSGALSPRAPRQAGHARMEALARLPVFFGLEGRRVLVAGGGEPAAWKAELL CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCCHHHHHHH SAAGARVEVIAPHVCEDLWRLAGAPPRGPISIHVRDWHADDIPGAVLAVAGFDEEADALN HHCCCEEEEECHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCC FTTAARAAGVPVNAIDKPALSDFTFGAIVNRSPLVVGISTDGAAPVFGQAVRAKIEALLP HHHHHHHCCCCCCCCCCCCCCCCCHHHEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCC SGFKAWALAAKTWRQAVTARGLSHHARRAFWERFAATALAEPNRAPQDTDRAALFTAIEA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEC EGTPHRSGHAGSVVLVGAGPGDPELLTLKAVRALQSADVVLYDDLVSGAILDFARREAKK CCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH MLVGKTGYGPSCKQDDINALMVDLAKEGRRVVRLKGGEPMIFGRAGEEITHCHAAGVPVE HHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHCCCCEE VIPGISAPQGAASRLVTSLTHRDHARRLQFVTAHARDGKLPKDLDFNALADKAATTVVYM ECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHCEEEEEE PRRTLPDLVRNLMAAGIDPATPAVAMFSVTRPEEKVILATVATLAEEVARAAEVGAQGPC CCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE LILYGQALAEVAVDALPQIVQAAANGG EEEEHHHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure AATGPDTPNSGALSPRAPRQAGHARMEALARLPVFFGLEGRRVLVAGGGEPAAWKAELL CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEEEECCCCCCHHHHHHH SAAGARVEVIAPHVCEDLWRLAGAPPRGPISIHVRDWHADDIPGAVLAVAGFDEEADALN HHCCCEEEEECHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCC FTTAARAAGVPVNAIDKPALSDFTFGAIVNRSPLVVGISTDGAAPVFGQAVRAKIEALLP HHHHHHHCCCCCCCCCCCCCCCCCHHHEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCC SGFKAWALAAKTWRQAVTARGLSHHARRAFWERFAATALAEPNRAPQDTDRAALFTAIEA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEC EGTPHRSGHAGSVVLVGAGPGDPELLTLKAVRALQSADVVLYDDLVSGAILDFARREAKK CCCCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHH MLVGKTGYGPSCKQDDINALMVDLAKEGRRVVRLKGGEPMIFGRAGEEITHCHAAGVPVE HHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHCCCCEE VIPGISAPQGAASRLVTSLTHRDHARRLQFVTAHARDGKLPKDLDFNALADKAATTVVYM ECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHCEEEEEE PRRTLPDLVRNLMAAGIDPATPAVAMFSVTRPEEKVILATVATLAEEVARAAEVGAQGPC CCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE LILYGQALAEVAVDALPQIVQAAANGG EEEEHHHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA