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The map label for this gene is hisB

Identifier: 154246235

GI number: 154246235

Start: 2557355

End: 2557948

Strand: Reverse

Name: hisB

Synonym: Xaut_2293

Alternate gene names: 154246235

Gene position: 2557948-2557355 (Counterclockwise)

Preceding gene: 154246239

Following gene: 154246234

Centisome position: 48.18

GC content: 67.51

Gene sequence:

>594_bases
ATGCGCAAGGCCGACATCGTCCGCGAAACCAAGGAGACCCGCGTCGCCCTCACCGTCGATCTCGACGGAACGGGCCGCTC
TGCCATCTCCACCGGGATCGGCTTCCTGGACCACATGCTGGACCTGTTGGCCCGGCACGCCCGCTTTGACCTTGAGATCA
AGGCCGACGGCGACCTCCATGTGGATTTCCACCACACCACCGAGGATGTGGGCATCGTGCTCGGCCAGGCGCTGAAGAAG
GCGCTCGGCGACATGCGCGGCATCACCCGCTACGCCGACGTGCTGCTGCCCATGGACGAGACGCTGACCCGCGTCGCCCT
CGACATTTCGGGCCGGCCGTTCCTGGTGTTCCGCACCGAATTCGCGGTGCCCAAGATCGGCGAGTTCGACACCGAGCTGG
TGCGTGAGTTCTTCCAGGCCTTCGCCTCCAGCGCCGGGGTGACCCTGCATGTGGAGACCCTGTATGGCGTGAACGCCCAC
CACATCGCGGAAAGCTGCTTCAAGGGCCTTGCCCGGGTGCTGCGGGCGGCGGTGGCGGTGGACCCGGCGGCGGCGGGGGA
GATCCCCTCCACCAAGGGCGCGCTGGGAACCTGA

Upstream 100 bases:

>100_bases
GGCCCGGCGACGAGACGATCAGACGCCGGAAACGTCATCTCTTCGCCATATGGCGTCGCAGCGAGGTTGCTGATAGAACC
CGCGGCCTTGGAGGAGTTCC

Downstream 100 bases:

>100_bases
GGAGCCGGGCGATGGGCATCTGGACGGTCCTGAGCAGGACGGAACCCGGCGACACCGCCGAGGCGGTGGCCGGCGGCACC
GTGTTCGTGCGCGAGAAATT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRKADIVRETKETRVALTVDLDGTGRSAISTGIGFLDHMLDLLARHARFDLEIKADGDLHVDFHHTTEDVGIVLGQALKK
ALGDMRGITRYADVLLPMDETLTRVALDISGRPFLVFRTEFAVPKIGEFDTELVREFFQAFASSAGVTLHVETLYGVNAH
HIAESCFKGLARVLRAAVAVDPAAAGEIPSTKGALGT

Sequences:

>Translated_197_residues
MRKADIVRETKETRVALTVDLDGTGRSAISTGIGFLDHMLDLLARHARFDLEIKADGDLHVDFHHTTEDVGIVLGQALKK
ALGDMRGITRYADVLLPMDETLTRVALDISGRPFLVFRTEFAVPKIGEFDTELVREFFQAFASSAGVTLHVETLYGVNAH
HIAESCFKGLARVLRAAVAVDPAAAGEIPSTKGALGT
>Mature_197_residues
MRKADIVRETKETRVALTVDLDGTGRSAISTGIGFLDHMLDLLARHARFDLEIKADGDLHVDFHHTTEDVGIVLGQALKK
ALGDMRGITRYADVLLPMDETLTRVALDISGRPFLVFRTEFAVPKIGEFDTELVREFFQAFASSAGVTLHVETLYGVNAH
HIAESCFKGLARVLRAAVAVDPAAAGEIPSTKGALGT

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50.5154639175258, Blast_Score=192, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.9082568807339, Blast_Score=165, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_XANP2 (A7IHP3)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417193.1
- ProteinModelPortal:   A7IHP3
- SMR:   A7IHP3
- STRING:   A7IHP3
- GeneID:   5420812
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2293
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   XAUT78245:XAUT_2293-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21357; Mature: 21357

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKADIVRETKETRVALTVDLDGTGRSAISTGIGFLDHMLDLLARHARFDLEIKADGDLH
CCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEE
VDFHHTTEDVGIVLGQALKKALGDMRGITRYADVLLPMDETLTRVALDISGRPFLVFRTE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCEEEEEEEC
FAVPKIGEFDTELVREFFQAFASSAGVTLHVETLYGVNAHHIAESCFKGLARVLRAAVAV
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DPAAAGEIPSTKGALGT
CCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRKADIVRETKETRVALTVDLDGTGRSAISTGIGFLDHMLDLLARHARFDLEIKADGDLH
CCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEE
VDFHHTTEDVGIVLGQALKKALGDMRGITRYADVLLPMDETLTRVALDISGRPFLVFRTE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCEEEEEEEC
FAVPKIGEFDTELVREFFQAFASSAGVTLHVETLYGVNAHHIAESCFKGLARVLRAAVAV
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DPAAAGEIPSTKGALGT
CCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA