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The map label for this gene is gcvT [H]

Identifier: 154246144

GI number: 154246144

Start: 2459880

End: 2461025

Strand: Reverse

Name: gcvT [H]

Synonym: Xaut_2201

Alternate gene names: 154246144

Gene position: 2461025-2459880 (Counterclockwise)

Preceding gene: 154246145

Following gene: 154246143

Centisome position: 46.36

GC content: 70.86

Gene sequence:

>1146_bases
TTGGATCATTCCGAGCCTCTGCTCGAAACCCCGCTGTTCTCCGCCCATCGCGCCCTCGGCGCACGCATGGTGCCGTTCGC
CGGCTACCAGATGCCGGTGCAATATCCCGAAGGCATCCTCGCGGAGCACGGCTGGACCCGCACCCGTGCCGGCCTGTTCG
ATGTCTCCCACATGGGCCAGGCCCTGCTGAAGGGGTCCGACCACGCCACCACCGCCCGAGCCCTCGAAGCCCTCGCCCCT
GCAGATTTCCTGAATCTCGCGCCCGGCCGCCAGCGCTATTCCCAGCTCCTGGCCGAGGATGGCGGCATCATCGACGACTT
CATGGTGACGCGGCCGCTGGCGCCGGAGGCGGACGGCACCCTCATCCTCGTGGTCAACGCCGCCTGCAAGGCCGGCGACT
TCGCCCACATCGCCGCCCACCTACCGGAGGGCGTCGCCCTCGTCGAGCGCCCGGAGCGCGCGCTGCTCGCCCTGCAGGGG
CCGGAAGCCGCAGCCGTCATGGCCCGCCACTGCCCTGAGGCGGCGACGCTGGACTTCATGGCGGCCATCCCGACTGAATT
CGACGGCATCCCGGTGGAGGTCTCCCGCTCCGGCTACACCGGCGAGGACGGTTTTGAAATCTCGGTCGAGAACGAAAGCG
CGCCCCTTCTGTGGGCCGCCCTGCTCGCCGAGCCGGAGGTGAAGGCCATCGGCCTCGGAGCCCGCGACAGCCTGCGCCTT
GAGGCCGGGCTCTGCCTCTATGGCCACGACATCGATCTTTCCACGTCCCCCATCGAGGCGGCGCTCAACTGGTCCATCCA
GAAGCGGCGGCGCACGGAGGGCGGCTTTCCCGGCGACGCGCGTATTCAGCGCGAGTTGGCGCAAGGCCCGGCCCGCGTTC
GGGTGGGGCTGAGGCTGGAAGGCCGCGCGCCGGCCCGCGAGGGGGCCGAGATCGCATCCGATGGCGCCGTGGTGGGGCGC
GTCACCTCCGGCGGCTTCGCGCCGACGCTCGGTGCCCCCATCGCCATGGGCTACGTGCCGCCGGCCCTGTCGGCGCCCGG
CACCCGCCTCGACGTTCTGGTGCGCGGCAAGGCTTTGGCGGCCACTGTCGCATCCCTCCCGTTCGTGCCGACGCGCTATG
CGCGCAAACCTAAAACTGGGGCCTGA

Upstream 100 bases:

>100_bases
GGGGGCGCCGCGCGGACCTGCGTCTTGCGCCGTTACGACCTTTTGTGTCGTCGCGCGAGGGACAGGTCCGGAAATTGGCG
CTGTCGTCCGGGAGCCCCCC

Downstream 100 bases:

>100_bases
TCCATGACGAGCGTGCGCTACACGAAGGACCACGAATATGTGCGCGTCGAAGGCGACGTGGCCGTGGTGGGCATCTCCGA
CTATGCCCAGCAGCAGCTGG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDHSEPLLETPLFSAHRALGARMVPFAGYQMPVQYPEGILAEHGWTRTRAGLFDVSHMGQALLKGSDHATTARALEALAP
ADFLNLAPGRQRYSQLLAEDGGIIDDFMVTRPLAPEADGTLILVVNAACKAGDFAHIAAHLPEGVALVERPERALLALQG
PEAAAVMARHCPEAATLDFMAAIPTEFDGIPVEVSRSGYTGEDGFEISVENESAPLLWAALLAEPEVKAIGLGARDSLRL
EAGLCLYGHDIDLSTSPIEAALNWSIQKRRRTEGGFPGDARIQRELAQGPARVRVGLRLEGRAPAREGAEIASDGAVVGR
VTSGGFAPTLGAPIAMGYVPPALSAPGTRLDVLVRGKALAATVASLPFVPTRYARKPKTGA

Sequences:

>Translated_381_residues
MDHSEPLLETPLFSAHRALGARMVPFAGYQMPVQYPEGILAEHGWTRTRAGLFDVSHMGQALLKGSDHATTARALEALAP
ADFLNLAPGRQRYSQLLAEDGGIIDDFMVTRPLAPEADGTLILVVNAACKAGDFAHIAAHLPEGVALVERPERALLALQG
PEAAAVMARHCPEAATLDFMAAIPTEFDGIPVEVSRSGYTGEDGFEISVENESAPLLWAALLAEPEVKAIGLGARDSLRL
EAGLCLYGHDIDLSTSPIEAALNWSIQKRRRTEGGFPGDARIQRELAQGPARVRVGLRLEGRAPAREGAEIASDGAVVGR
VTSGGFAPTLGAPIAMGYVPPALSAPGTRLDVLVRGKALAATVASLPFVPTRYARKPKTGA
>Mature_381_residues
MDHSEPLLETPLFSAHRALGARMVPFAGYQMPVQYPEGILAEHGWTRTRAGLFDVSHMGQALLKGSDHATTARALEALAP
ADFLNLAPGRQRYSQLLAEDGGIIDDFMVTRPLAPEADGTLILVVNAACKAGDFAHIAAHLPEGVALVERPERALLALQG
PEAAAVMARHCPEAATLDFMAAIPTEFDGIPVEVSRSGYTGEDGFEISVENESAPLLWAALLAEPEVKAIGLGARDSLRL
EAGLCLYGHDIDLSTSPIEAALNWSIQKRRRTEGGFPGDARIQRELAQGPARVRVGLRLEGRAPAREGAEIASDGAVVGR
VTSGGFAPTLGAPIAMGYVPPALSAPGTRLDVLVRGKALAATVASLPFVPTRYARKPKTGA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=379, Percent_Identity=45.1187335092348, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=44.6927374301676, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI257796254, Length=375, Percent_Identity=41.0666666666667, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI257796256, Length=323, Percent_Identity=44.5820433436532, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI24797151, Length=364, Percent_Identity=27.1978021978022, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI197927446, Length=318, Percent_Identity=27.6729559748428, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21361378, Length=318, Percent_Identity=27.6729559748428, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789272, Length=370, Percent_Identity=35.6756756756757, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=40.5263157894737, Blast_Score=214, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6320222, Length=394, Percent_Identity=41.3705583756345, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI20129441, Length=384, Percent_Identity=42.4479166666667, Blast_Score=270, Evalue=2e-72,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40207; Mature: 40207

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHSEPLLETPLFSAHRALGARMVPFAGYQMPVQYPEGILAEHGWTRTRAGLFDVSHMGQ
CCCCCCCHHCCHHHHHHHHCCEECCCCCCCCCCCCCCCHHHCCCCCHHHCCHHHHHHHHH
ALLKGSDHATTARALEALAPADFLNLAPGRQRYSQLLAEDGGIIDDFMVTRPLAPEADGT
HHHCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCE
LILVVNAACKAGDFAHIAAHLPEGVALVERPERALLALQGPEAAAVMARHCPEAATLDFM
EEEEEECCCCCCCHHHHHHHCCCCCEEHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHH
AAIPTEFDGIPVEVSRSGYTGEDGFEISVENESAPLLWAALLAEPEVKAIGLGARDSLRL
HHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCEEE
EAGLCLYGHDIDLSTSPIEAALNWSIQKRRRTEGGFPGDARIQRELAQGPARVRVGLRLE
ECCEEEEECCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEC
GRAPAREGAEIASDGAVVGRVTSGGFAPTLGAPIAMGYVPPALSAPGTRLDVLVRGKALA
CCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECHHHH
ATVASLPFVPTRYARKPKTGA
HHHHHCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MDHSEPLLETPLFSAHRALGARMVPFAGYQMPVQYPEGILAEHGWTRTRAGLFDVSHMGQ
CCCCCCCHHCCHHHHHHHHCCEECCCCCCCCCCCCCCCHHHCCCCCHHHCCHHHHHHHHH
ALLKGSDHATTARALEALAPADFLNLAPGRQRYSQLLAEDGGIIDDFMVTRPLAPEADGT
HHHCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCE
LILVVNAACKAGDFAHIAAHLPEGVALVERPERALLALQGPEAAAVMARHCPEAATLDFM
EEEEEECCCCCCCHHHHHHHCCCCCEEHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHH
AAIPTEFDGIPVEVSRSGYTGEDGFEISVENESAPLLWAALLAEPEVKAIGLGARDSLRL
HHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCEEE
EAGLCLYGHDIDLSTSPIEAALNWSIQKRRRTEGGFPGDARIQRELAQGPARVRVGLRLE
ECCEEEEECCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEC
GRAPAREGAEIASDGAVVGRVTSGGFAPTLGAPIAMGYVPPALSAPGTRLDVLVRGKALA
CCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECHHHH
ATVASLPFVPTRYARKPKTGA
HHHHHCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA