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The map label for this gene is hoxL [H]

Identifier: 154246117

GI number: 154246117

Start: 2434794

End: 2436608

Strand: Direct

Name: hoxL [H]

Synonym: Xaut_2174

Alternate gene names: 154246117

Gene position: 2434794-2436608 (Clockwise)

Preceding gene: 154246116

Following gene: 154246118

Centisome position: 45.86

GC content: 64.08

Gene sequence:

>1815_bases
GTGACCATCCAGACGCCGAATGGCTTTTCCCTCGACACCTCCGGCAAGCGCATCGTGGTCGATCCGGTCACCCGCATCGA
AGGCCACATGCGCTGCGAGGTGAATGTCGATTCCAACAACATCATCCGCAACGCGGTCTCCACCGGCACCATGTGGCGCG
GGCTGGAAGTGATCCTGAAGGGCCGCGACCCGCGCGACGCCTGGGCCTTCGTGGAGCGCATCTGCGGCGTGTGCACCGGT
TGCCACGCGCTGACCTCCGTGCGCGCGGTGGAAGACGCGCTGCAGATCAAGATCCCGAACAATGCCTTCCTGATCCGCGA
GATCATGGCCAAGGTGCTGCAGTGGCATGACCATGTGGTCCATTTCTACCACCTGCATGCGCTGGACTGGGTGAACCCGG
TCAACGCGCTCAAGGCGGACCCGAAGGCGACGAGCGTCCTGCAGCAGTCCATCTCGGCGCATTCCAAGTCCTCACCGGGC
TATTTCCGCGACGTGCAGAACCGGCTGAAGAAGTTCGTGGAGAGCGGACAGCTCGGCATCTTCAAGAACGGCTATTGGGA
CAATCCGGCCTATCTCCTGCCTCCCGAGGCGGACCTGCTGGCGGTGACGCACTATCTGGAAGCGCTCGACTTCCAGAAAG
AGATCGTGAAGGTCCACACCATCTTCGGCGGCAAGAACCCGCATCCGAACTACCTGGTTGGCGGCGTGCCCTGCGCCATC
AATATGGACGGCGACCTGGCCGCCGGCGCTCCGCTCAACATGGAGCGGCTGAACTTCGTGAAGCTGAAGCTTCAGGAAGC
CTTCGAGTTCTCCCAGAACGTCTATGTGCCGGACGTGATCGCCATCGCCAGCTTCTACAAGGGCTGGCTCTATGGCGGCG
GCCTCTCCGGCCAGAACGTAATGGATTACGGCGACTACGAAGCCATCCAGGGCCAGAAGAAGACCGACCGCCTGCCCGGC
GGCGTCATCCTCAACGGCAACTGGAACGAGGTGCACCCCATCGATCCGCGCAATCCGGACGAGGTGCAGGAATTCGTGGC
GCACTCCTGGTACACCTACGGCGATGCGAACAAGGACAAGGGCCTGCATCCGTGGGACGGCATCACCGATCCCCAGTATG
TGCTCGGCCCCAATGCCAAGGGCACCCGCACCAATATCGAGGCGGTGGACGAGAACGCGAAGTATTCCTGGATCAAGGCA
CCGCGCTGGAAGGGCAATGCGGTGGAGGTGGGTCCGCTCGCCCGCTACATCCTCGCCTATGCCCAGGGCGTCGACTATGT
GAAGGGGCAGGTGGACGAGGCTCTGGGCCAGTTCAACACCTTGGCCGGCACCCAGCTGACCGCAAAGCAGGCGCTGCCCT
CCACCATCGGGCGCACCCTCGCCCGCGCGCTGGAGGCCCACTACTGCGCCAAGATGTTCCTGGATGATTTCGACCACCTC
ATCGCCAACATCAAGGCCGGCGACACCTCCACCGCCAACATGGAGAAGTGGGACCCCTCGACCTGGCCGAAGGAGGCCAA
GGGCGTGGGTACGGTGGCGGCGCCGCGCGGCGGCCTCGGCCACTGGATCAAGATCAAGGACGGGCGGATCGAGAACTACC
AGTGCGTGGTGCCCACCACCTGGAACGGCGGGCCGCGCGATCCCAAGGGCAATATCGGCGCGTTCGAGGCCTCCCTCATG
AACACGCCCATGCAGCGCCCCGAGGAGCCGGTGGAGATCCTGCGCACCCTGCACTCGTTCGACCCGTGCCTGGCCTGCTC
CACCCATGTCATGTCCGAAGGCGGCGAGGAACTCGCCCGCGTCACCGTCCGCTGA

Upstream 100 bases:

>100_bases
GCGCGGGGGTCGCGGTTCACGCGGCGGTGAGTGCGCTCAAGCGCGCCCAGCACAAGAATACGGACAACGGCGCTGACACG
GGCGCGACGGGAGGCGAGAA

Downstream 100 bases:

>100_bases
GGGAGGGATGCCATGAGCGAGACCTCACTGTCCGGCGCCGCGCCTCCGGCGGCCCCTGTTTCCCCGGTTGCCAAGGCGGC
GGCCGGTGGAAAGAAGCTGA

Product: nickel-dependent hydrogenase large subunit

Products: NA

Alternate protein names: Hydrogenlyase; Membrane-bound hydrogenase large subunit [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTIQTPNGFSLDTSGKRIVVDPVTRIEGHMRCEVNVDSNNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTG
CHALTSVRAVEDALQIKIPNNAFLIREIMAKVLQWHDHVVHFYHLHALDWVNPVNALKADPKATSVLQQSISAHSKSSPG
YFRDVQNRLKKFVESGQLGIFKNGYWDNPAYLLPPEADLLAVTHYLEALDFQKEIVKVHTIFGGKNPHPNYLVGGVPCAI
NMDGDLAAGAPLNMERLNFVKLKLQEAFEFSQNVYVPDVIAIASFYKGWLYGGGLSGQNVMDYGDYEAIQGQKKTDRLPG
GVILNGNWNEVHPIDPRNPDEVQEFVAHSWYTYGDANKDKGLHPWDGITDPQYVLGPNAKGTRTNIEAVDENAKYSWIKA
PRWKGNAVEVGPLARYILAYAQGVDYVKGQVDEALGQFNTLAGTQLTAKQALPSTIGRTLARALEAHYCAKMFLDDFDHL
IANIKAGDTSTANMEKWDPSTWPKEAKGVGTVAAPRGGLGHWIKIKDGRIENYQCVVPTTWNGGPRDPKGNIGAFEASLM
NTPMQRPEEPVEILRTLHSFDPCLACSTHVMSEGGEELARVTVR

Sequences:

>Translated_604_residues
MTIQTPNGFSLDTSGKRIVVDPVTRIEGHMRCEVNVDSNNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTG
CHALTSVRAVEDALQIKIPNNAFLIREIMAKVLQWHDHVVHFYHLHALDWVNPVNALKADPKATSVLQQSISAHSKSSPG
YFRDVQNRLKKFVESGQLGIFKNGYWDNPAYLLPPEADLLAVTHYLEALDFQKEIVKVHTIFGGKNPHPNYLVGGVPCAI
NMDGDLAAGAPLNMERLNFVKLKLQEAFEFSQNVYVPDVIAIASFYKGWLYGGGLSGQNVMDYGDYEAIQGQKKTDRLPG
GVILNGNWNEVHPIDPRNPDEVQEFVAHSWYTYGDANKDKGLHPWDGITDPQYVLGPNAKGTRTNIEAVDENAKYSWIKA
PRWKGNAVEVGPLARYILAYAQGVDYVKGQVDEALGQFNTLAGTQLTAKQALPSTIGRTLARALEAHYCAKMFLDDFDHL
IANIKAGDTSTANMEKWDPSTWPKEAKGVGTVAAPRGGLGHWIKIKDGRIENYQCVVPTTWNGGPRDPKGNIGAFEASLM
NTPMQRPEEPVEILRTLHSFDPCLACSTHVMSEGGEELARVTVR
>Mature_603_residues
TIQTPNGFSLDTSGKRIVVDPVTRIEGHMRCEVNVDSNNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGC
HALTSVRAVEDALQIKIPNNAFLIREIMAKVLQWHDHVVHFYHLHALDWVNPVNALKADPKATSVLQQSISAHSKSSPGY
FRDVQNRLKKFVESGQLGIFKNGYWDNPAYLLPPEADLLAVTHYLEALDFQKEIVKVHTIFGGKNPHPNYLVGGVPCAIN
MDGDLAAGAPLNMERLNFVKLKLQEAFEFSQNVYVPDVIAIASFYKGWLYGGGLSGQNVMDYGDYEAIQGQKKTDRLPGG
VILNGNWNEVHPIDPRNPDEVQEFVAHSWYTYGDANKDKGLHPWDGITDPQYVLGPNAKGTRTNIEAVDENAKYSWIKAP
RWKGNAVEVGPLARYILAYAQGVDYVKGQVDEALGQFNTLAGTQLTAKQALPSTIGRTLARALEAHYCAKMFLDDFDHLI
ANIKAGDTSTANMEKWDPSTWPKEAKGVGTVAAPRGGLGHWIKIKDGRIENYQCVVPTTWNGGPRDPKGNIGAFEASLMN
TPMQRPEEPVEILRTLHSFDPCLACSTHVMSEGGEELARVTVR

Specific function: This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions [H]

COG id: COG0374

COG function: function code C; Ni,Fe-hydrogenase I large subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1787207, Length=601, Percent_Identity=58.5690515806988, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1789368, Length=597, Percent_Identity=42.8810720268007, Blast_Score=467, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.99.6 [H]

Molecular weight: Translated: 66868; Mature: 66736

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00507 NI_HGENASE_L_1 ; PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQTPNGFSLDTSGKRIVVDPVTRIEGHMRCEVNVDSNNIIRNAVSTGTMWRGLEVILK
CCCCCCCCCEECCCCCEEEECCHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHCHHHEEE
GRDPRDAWAFVERICGVCTGCHALTSVRAVEDALQIKIPNNAFLIREIMAKVLQWHDHVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHH
HFYHLHALDWVNPVNALKADPKATSVLQQSISAHSKSSPGYFRDVQNRLKKFVESGQLGI
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
FKNGYWDNPAYLLPPEADLLAVTHYLEALDFQKEIVKVHTIFGGKNPHPNYLVGGVPCAI
EECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCEEE
NMDGDLAAGAPLNMERLNFVKLKLQEAFEFSQNVYVPDVIAIASFYKGWLYGGGLSGQNV
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
MDYGDYEAIQGQKKTDRLPGGVILNGNWNEVHPIDPRNPDEVQEFVAHSWYTYGDANKDK
CCCCCHHHHCCCCHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCC
GLHPWDGITDPQYVLGPNAKGTRTNIEAVDENAKYSWIKAPRWKGNAVEVGPLARYILAY
CCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AQGVDYVKGQVDEALGQFNTLAGTQLTAKQALPSTIGRTLARALEAHYCAKMFLDDFDHL
HHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IANIKAGDTSTANMEKWDPSTWPKEAKGVGTVAAPRGGLGHWIKIKDGRIENYQCVVPTT
HHCCCCCCCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCCCEEEEECCCCCCEEEEEEEC
WNGGPRDPKGNIGAFEASLMNTPMQRPEEPVEILRTLHSFDPCLACSTHVMSEGGEELAR
CCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHH
VTVR
EECC
>Mature Secondary Structure 
TIQTPNGFSLDTSGKRIVVDPVTRIEGHMRCEVNVDSNNIIRNAVSTGTMWRGLEVILK
CCCCCCCCEECCCCCEEEECCHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHCHHHEEE
GRDPRDAWAFVERICGVCTGCHALTSVRAVEDALQIKIPNNAFLIREIMAKVLQWHDHVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHH
HFYHLHALDWVNPVNALKADPKATSVLQQSISAHSKSSPGYFRDVQNRLKKFVESGQLGI
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEE
FKNGYWDNPAYLLPPEADLLAVTHYLEALDFQKEIVKVHTIFGGKNPHPNYLVGGVPCAI
EECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCEEE
NMDGDLAAGAPLNMERLNFVKLKLQEAFEFSQNVYVPDVIAIASFYKGWLYGGGLSGQNV
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
MDYGDYEAIQGQKKTDRLPGGVILNGNWNEVHPIDPRNPDEVQEFVAHSWYTYGDANKDK
CCCCCHHHHCCCCHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCC
GLHPWDGITDPQYVLGPNAKGTRTNIEAVDENAKYSWIKAPRWKGNAVEVGPLARYILAY
CCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AQGVDYVKGQVDEALGQFNTLAGTQLTAKQALPSTIGRTLARALEAHYCAKMFLDDFDHL
HHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IANIKAGDTSTANMEKWDPSTWPKEAKGVGTVAAPRGGLGHWIKIKDGRIENYQCVVPTT
HHCCCCCCCCCCCCCCCCCCCCCHHHCCCCEECCCCCCCCCEEEEECCCCCCEEEEEEEC
WNGGPRDPKGNIGAFEASLMNTPMQRPEEPVEILRTLHSFDPCLACSTHVMSEGGEELAR
CCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHH
VTVR
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9324252 [H]