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The map label for this gene is cbh [H]

Identifier: 154246070

GI number: 154246070

Start: 2386825

End: 2388108

Strand: Reverse

Name: cbh [H]

Synonym: Xaut_2127

Alternate gene names: 154246070

Gene position: 2388108-2386825 (Counterclockwise)

Preceding gene: 154246072

Following gene: 154246069

Centisome position: 44.98

GC content: 66.98

Gene sequence:

>1284_bases
ATGTCTTTTCGGGGCAGACAGGGCATGGATGACCGGCTCCGCCTTGCTGTGTGGGCGGAGCCGGTATCTCTTTCAGCCGT
CTATCCGGCGGTCGATGCGGTGCTGCTGGAGCCTCAGGCTCCGGCAGCACGCTCAAAAAATAATCCGGCCGCCCAACCGG
AGACGGTCATGCCGCTTACGCGCGCCCCCCTCACATTCAAGTCCATCCGCACCGCCGCACTCGCCGCCGCCGCGCTCTAT
GTCGCAGGCCTTGGCGCCGGGGTGGCGCAGGCCTGCACCCGCGCGGTCTATCTCGGCTCCGATGGCGTGGTCATCACCGG
CCGGTCCATGGACTGGGCGGAAGACATGCGCACCAATCTCTGGGCGTTCCCGGCGGGCATGGCACGCAGCGGCGCAGCGG
GCGCCAACACCCCGAAATGGGTGGCCAAATACGGCAGCCTCATCGCCTCCGGCTATGACGTGGGCACGGCAGACGGCATG
AACGAGAAAGGCCTCGTCGCCAACCTGCTCTATCTGGCCGAATCCGAATATGCCAAGCCCGATGGCCGCCCCGCCCTCTC
CATCAGCCTGTGGGCGCAATATGTGCTCGACAATTTCGCCACCGTGAGCGAGGCGGTGACGGCGCTGTCCGCCGAGCCGT
TCGTGGTGGTGACGGCGAACCTGCCCAATGGCGCGGGCGCACAGTTGCACCTCGCTATCTCCGATCCCTCCGGCGACAGC
GCCATCTTCGAATATCTGGGCGGCAAGCTGGTGGTCCACCATGGCCGCCAATACCAGGTGATGACCAATTCGCCGTCGTT
CGACCAGCAGCTGGCGCTGAACAGCTACTGGCAGCAGATCGGCGGCACGGTGTTCCTGCCCGGCACCAACCGGGCGGCCG
ACCGCTTCGCCCGCGCCAGCTTCTTCATCAAGGCCATTCCGACGCAGGCCGCCCCGGCCATCCTCACCGCCGTGCCGGAG
GGCACCTATGCCAACCAGGCGGTGGCCAGCGTCGCCAGCGTGATGCGCTCGGTGAGCGTGCCGCTGGGCCTCACCACGCC
CGGCGAGCCGAACATCGCCTCCACCCTGTGGCGGACGGTGAGCGACCAGAAGGACCGCGTCTATTTCTTCGATTCCGCCA
CCAGCCCCAACAGCTTCTGGGTGCCCCTCGACAGTCTCGACCTCAAGGCCGGGGCGCCGGTGAAGAAGCTGACGCTGACC
GGCGGCAAGGTCTATTCGGGCAATGCGGCCGGGCACTTCGAGCCGGCCCAGCCCTTCGCCTTCCTGCCCGTGGACGTGAA
GTAG

Upstream 100 bases:

>100_bases
GCTACGACTTTTGTCCATAGCAAAAATCTGACCGGCTTCCGCGAAATTTGATCCATCTCAGAGAATCCAGCCGGGGGTGG
TGGTTATCTCCCTCTTGTCC

Downstream 100 bases:

>100_bases
CACGCCCCGGCTGCATCGGCGGGACCGGACAGCGCGGGGCGGCCAAGGGCTGCCGCGCGTTGTCCCGGGCTGCCCCGTCC
AAGATGCTGCAATGCGGTAA

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSFRGRQGMDDRLRLAVWAEPVSLSAVYPAVDAVLLEPQAPAARSKNNPAAQPETVMPLTRAPLTFKSIRTAALAAAALY
VAGLGAGVAQACTRAVYLGSDGVVITGRSMDWAEDMRTNLWAFPAGMARSGAAGANTPKWVAKYGSLIASGYDVGTADGM
NEKGLVANLLYLAESEYAKPDGRPALSISLWAQYVLDNFATVSEAVTALSAEPFVVVTANLPNGAGAQLHLAISDPSGDS
AIFEYLGGKLVVHHGRQYQVMTNSPSFDQQLALNSYWQQIGGTVFLPGTNRAADRFARASFFIKAIPTQAAPAILTAVPE
GTYANQAVASVASVMRSVSVPLGLTTPGEPNIASTLWRTVSDQKDRVYFFDSATSPNSFWVPLDSLDLKAGAPVKKLTLT
GGKVYSGNAAGHFEPAQPFAFLPVDVK

Sequences:

>Translated_427_residues
MSFRGRQGMDDRLRLAVWAEPVSLSAVYPAVDAVLLEPQAPAARSKNNPAAQPETVMPLTRAPLTFKSIRTAALAAAALY
VAGLGAGVAQACTRAVYLGSDGVVITGRSMDWAEDMRTNLWAFPAGMARSGAAGANTPKWVAKYGSLIASGYDVGTADGM
NEKGLVANLLYLAESEYAKPDGRPALSISLWAQYVLDNFATVSEAVTALSAEPFVVVTANLPNGAGAQLHLAISDPSGDS
AIFEYLGGKLVVHHGRQYQVMTNSPSFDQQLALNSYWQQIGGTVFLPGTNRAADRFARASFFIKAIPTQAAPAILTAVPE
GTYANQAVASVASVMRSVSVPLGLTTPGEPNIASTLWRTVSDQKDRVYFFDSATSPNSFWVPLDSLDLKAGAPVKKLTLT
GGKVYSGNAAGHFEPAQPFAFLPVDVK
>Mature_426_residues
SFRGRQGMDDRLRLAVWAEPVSLSAVYPAVDAVLLEPQAPAARSKNNPAAQPETVMPLTRAPLTFKSIRTAALAAAALYV
AGLGAGVAQACTRAVYLGSDGVVITGRSMDWAEDMRTNLWAFPAGMARSGAAGANTPKWVAKYGSLIASGYDVGTADGMN
EKGLVANLLYLAESEYAKPDGRPALSISLWAQYVLDNFATVSEAVTALSAEPFVVVTANLPNGAGAQLHLAISDPSGDSA
IFEYLGGKLVVHHGRQYQVMTNSPSFDQQLALNSYWQQIGGTVFLPGTNRAADRFARASFFIKAIPTQAAPAILTAVPEG
TYANQAVASVASVMRSVSVPLGLTTPGEPNIASTLWRTVSDQKDRVYFFDSATSPNSFWVPLDSLDLKAGAPVKKLTLTG
GKVYSGNAAGHFEPAQPFAFLPVDVK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 45061; Mature: 44930

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS01159 WW_DOMAIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRGRQGMDDRLRLAVWAEPVSLSAVYPAVDAVLLEPQAPAARSKNNPAAQPETVMPLT
CCCCCCCCCCCCEEEEEEECCCCCEEHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
RAPLTFKSIRTAALAAAALYVAGLGAGVAQACTRAVYLGSDGVVITGRSMDWAEDMRTNL
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHH
WAFPAGMARSGAAGANTPKWVAKYGSLIASGYDVGTADGMNEKGLVANLLYLAESEYAKP
EECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
DGRPALSISLWAQYVLDNFATVSEAVTALSAEPFVVVTANLPNGAGAQLHLAISDPSGDS
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCH
AIFEYLGGKLVVHHGRQYQVMTNSPSFDQQLALNSYWQQIGGTVFLPGTNRAADRFARAS
HHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
FFIKAIPTQAAPAILTAVPEGTYANQAVASVASVMRSVSVPLGLTTPGEPNIASTLWRTV
HEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
SDQKDRVYFFDSATSPNSFWVPLDSLDLKAGAPVKKLTLTGGKVYSGNAAGHFEPAQPFA
CCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCEE
FLPVDVK
EEEEECC
>Mature Secondary Structure 
SFRGRQGMDDRLRLAVWAEPVSLSAVYPAVDAVLLEPQAPAARSKNNPAAQPETVMPLT
CCCCCCCCCCCEEEEEEECCCCCEEHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
RAPLTFKSIRTAALAAAALYVAGLGAGVAQACTRAVYLGSDGVVITGRSMDWAEDMRTNL
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHH
WAFPAGMARSGAAGANTPKWVAKYGSLIASGYDVGTADGMNEKGLVANLLYLAESEYAKP
EECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
DGRPALSISLWAQYVLDNFATVSEAVTALSAEPFVVVTANLPNGAGAQLHLAISDPSGDS
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCH
AIFEYLGGKLVVHHGRQYQVMTNSPSFDQQLALNSYWQQIGGTVFLPGTNRAADRFARAS
HHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHH
FFIKAIPTQAAPAILTAVPEGTYANQAVASVASVMRSVSVPLGLTTPGEPNIASTLWRTV
HEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
SDQKDRVYFFDSATSPNSFWVPLDSLDLKAGAPVKKLTLTGGKVYSGNAAGHFEPAQPFA
CCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCEE
FLPVDVK
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]