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The map label for this gene is hemA [H]

Identifier: 154246069

GI number: 154246069

Start: 2385273

End: 2386565

Strand: Reverse

Name: hemA [H]

Synonym: Xaut_2126

Alternate gene names: 154246069

Gene position: 2386565-2385273 (Counterclockwise)

Preceding gene: 154246070

Following gene: 154246063

Centisome position: 44.95

GC content: 68.75

Gene sequence:

>1293_bases
ATGAACTACGACAGCTTTTTTGCCGACGCCATCGACGCCCTGCGCAAGGAGCGCCGCTATCGGACCTTCGCCGAGATCGA
GCGTGACGCGCGCCATTTCCCGCGCGCCGTCTGGCATTCGCCCGGTGGCCCGCGCGACATCGTGGTGTGGTGCTCCAACG
ACTATCTGGGCATGGGCAGCCATCCCGACGTGGTCGCCGCCATGTGCGATGCGGCGAAAGCGCGCGGCGCCGGCGCCGGT
GGCACCCGCAACATCTCGGGCAACAGCCACGAGATCGTGATGCTGGAGCGCGAGCTGGCCGACCTGCACGGCAAGGAATC
CGGCCTCGTCTTCACCTCCGGCTACATTTCCAATGCCACCGGCATCTCCACCATCGTCAAGCTGATCCCCGACTGCGTGG
TGATCTCCGACGAGCTCAACCACAATTCCATGATCGAGGGCGTGCGCCACGGCGGCCGGCAGAAGGCCATCTTCCGCCAC
AACGACCTTGAGCACCTGGAAGAGCTGCTCAAGGCCGCCGGCGACCGTCCCAAGCTGGTGGTGTTCGAGAGCGTCTATTC
CATGGACGGCGACATCGCCCCCATCGGCGCCATCTGCGAGCTGGCCGAGCGCTACGGCGCCATGACCTATCTCGATGAAG
TCCACGCCGTGGGCATGTATGGCGAGCGCGGCGGCGGCGTGGCCGAGCGCGACGGCGTCATGCACAAGGTGGACGTGATC
GAGGGCACGCTGGGCAAGGCCTTCGGCGTGGTCGGCGGCTACATCACCGGCAAGCGCCTGATCATCGACGCGGTGCGCTC
CTATGCGCCGGGCTTCATCTTCACCACCGCGCTGCCCCCGGCGGTCGCGGCGGCGGCTGCCGCCTCGGTGCGGCACCTGA
AGAATTCGCAGGCGGAACGCGACGGCCAGCGCGCCCAGGTGGCCAAGGTCAAGCGCGCCCTCGCCGCCGCCGGCCTGCCG
CAGATGGACACCCCCACCCACATCGTCCCGGTGATGGTGGGCGACGCCAAGGCCTGCAAGATGGCGAGCGACCTGCTGCT
CGCCGAGTACGGCATCTATATCCAACCCATCAACTATCCCACCGTGCCCCGCGGCACCGAGCGGCTGCGCATCACCCCCA
CCCCGTTCCACGACGACGCGCTGATCGCCCATCTGGCCAAGGCGCTCACCGATGTGTGGGAGCGGCTGGAGCTGCCCTAC
GCCGACCGGGTGGCCGAACGCACCTCCGCCGCCTCGTCCCGCCGTACGGCGCTCGGCCCCGCGCCCATCCCGCTGCCGGT
GGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
TGGTATCAATACAAGGAGCAAGGTGCCGCGATAACCTTATAACAATGAGGAACGGCTCCTCGGAGCCGCACCCAGTCGCT
CAGTCGCCGCAGGGTTCGGA

Downstream 100 bases:

>100_bases
TACGACTGGTCTTTCACACATGAAAAAGCCCCGGCCGGTCCGGGGCTTTTTCAGTTTCGAGGCCGAGGATTAGGGGATCA
GGGCCTGCCTTGCATCGGTG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNYDSFFADAIDALRKERRYRTFAEIERDARHFPRAVWHSPGGPRDIVVWCSNDYLGMGSHPDVVAAMCDAAKARGAGAG
GTRNISGNSHEIVMLERELADLHGKESGLVFTSGYISNATGISTIVKLIPDCVVISDELNHNSMIEGVRHGGRQKAIFRH
NDLEHLEELLKAAGDRPKLVVFESVYSMDGDIAPIGAICELAERYGAMTYLDEVHAVGMYGERGGGVAERDGVMHKVDVI
EGTLGKAFGVVGGYITGKRLIIDAVRSYAPGFIFTTALPPAVAAAAAASVRHLKNSQAERDGQRAQVAKVKRALAAAGLP
QMDTPTHIVPVMVGDAKACKMASDLLLAEYGIYIQPINYPTVPRGTERLRITPTPFHDDALIAHLAKALTDVWERLELPY
ADRVAERTSAASSRRTALGPAPIPLPVAGG

Sequences:

>Translated_430_residues
MNYDSFFADAIDALRKERRYRTFAEIERDARHFPRAVWHSPGGPRDIVVWCSNDYLGMGSHPDVVAAMCDAAKARGAGAG
GTRNISGNSHEIVMLERELADLHGKESGLVFTSGYISNATGISTIVKLIPDCVVISDELNHNSMIEGVRHGGRQKAIFRH
NDLEHLEELLKAAGDRPKLVVFESVYSMDGDIAPIGAICELAERYGAMTYLDEVHAVGMYGERGGGVAERDGVMHKVDVI
EGTLGKAFGVVGGYITGKRLIIDAVRSYAPGFIFTTALPPAVAAAAAASVRHLKNSQAERDGQRAQVAKVKRALAAAGLP
QMDTPTHIVPVMVGDAKACKMASDLLLAEYGIYIQPINYPTVPRGTERLRITPTPFHDDALIAHLAKALTDVWERLELPY
ADRVAERTSAASSRRTALGPAPIPLPVAGG
>Mature_430_residues
MNYDSFFADAIDALRKERRYRTFAEIERDARHFPRAVWHSPGGPRDIVVWCSNDYLGMGSHPDVVAAMCDAAKARGAGAG
GTRNISGNSHEIVMLERELADLHGKESGLVFTSGYISNATGISTIVKLIPDCVVISDELNHNSMIEGVRHGGRQKAIFRH
NDLEHLEELLKAAGDRPKLVVFESVYSMDGDIAPIGAICELAERYGAMTYLDEVHAVGMYGERGGGVAERDGVMHKVDVI
EGTLGKAFGVVGGYITGKRLIIDAVRSYAPGFIFTTALPPAVAAAAAASVRHLKNSQAERDGQRAQVAKVKRALAAAGLP
QMDTPTHIVPVMVGDAKACKMASDLLLAEYGIYIQPINYPTVPRGTERLRITPTPFHDDALIAHLAKALTDVWERLELPY
ADRVAERTSAASSRRTALGPAPIPLPVAGG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=407, Percent_Identity=48.4029484029484, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI83977440, Length=407, Percent_Identity=48.4029484029484, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI83977444, Length=407, Percent_Identity=48.4029484029484, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.1315136476427, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.1315136476427, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=37.8223495702006, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=37.8223495702006, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4758668, Length=402, Percent_Identity=29.1044776119403, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI119220554, Length=378, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI5454084, Length=249, Percent_Identity=27.3092369477912, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1790046, Length=355, Percent_Identity=34.3661971830986, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=32.183908045977, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=362, Percent_Identity=37.0165745856354, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17560912, Length=383, Percent_Identity=27.9373368146214, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=383, Percent_Identity=27.9373368146214, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI32566772, Length=396, Percent_Identity=28.5353535353535, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=227, Percent_Identity=28.6343612334802, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=227, Percent_Identity=28.6343612334802, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=46.6824644549763, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=28.2608695652174, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=258, Percent_Identity=23.6434108527132, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=47.3815461346633, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=36.5921787709497, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI17136286, Length=384, Percent_Identity=26.8229166666667, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24653280, Length=257, Percent_Identity=26.8482490272374, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653276, Length=257, Percent_Identity=26.8482490272374, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653278, Length=257, Percent_Identity=26.8482490272374, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46342; Mature: 46342

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDSFFADAIDALRKERRYRTFAEIERDARHFPRAVWHSPGGPRDIVVWCSNDYLGMGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCC
HPDVVAAMCDAAKARGAGAGGTRNISGNSHEIVMLERELADLHGKESGLVFTSGYISNAT
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCEEEECCCCCCCH
GISTIVKLIPDCVVISDELNHNSMIEGVRHGGRQKAIFRHNDLEHLEELLKAAGDRPKLV
HHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHCCCCCCEE
VFESVYSMDGDIAPIGAICELAERYGAMTYLDEVHAVGMYGERGGGVAERDGVMHKVDVI
EEEHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEHHHH
EGTLGKAFGVVGGYITGKRLIIDAVRSYAPGFIFTTALPPAVAAAAAASVRHLKNSQAER
HHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
DGQRAQVAKVKRALAAAGLPQMDTPTHIVPVMVGDAKACKMASDLLLAEYGIYIQPINYP
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCC
TVPRGTERLRITPTPFHDDALIAHLAKALTDVWERLELPYADRVAERTSAASSRRTALGP
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
APIPLPVAGG
CCCCCCCCCC
>Mature Secondary Structure
MNYDSFFADAIDALRKERRYRTFAEIERDARHFPRAVWHSPGGPRDIVVWCSNDYLGMGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCC
HPDVVAAMCDAAKARGAGAGGTRNISGNSHEIVMLERELADLHGKESGLVFTSGYISNAT
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCEEEECCCCCCCH
GISTIVKLIPDCVVISDELNHNSMIEGVRHGGRQKAIFRHNDLEHLEELLKAAGDRPKLV
HHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHCCCCCCEE
VFESVYSMDGDIAPIGAICELAERYGAMTYLDEVHAVGMYGERGGGVAERDGVMHKVDVI
EEEHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHCCCEEEHHHH
EGTLGKAFGVVGGYITGKRLIIDAVRSYAPGFIFTTALPPAVAAAAAASVRHLKNSQAER
HHHHHHHHHHHCCHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
DGQRAQVAKVKRALAAAGLPQMDTPTHIVPVMVGDAKACKMASDLLLAEYGIYIQPINYP
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCC
TVPRGTERLRITPTPFHDDALIAHLAKALTDVWERLELPYADRVAERTSAASSRRTALGP
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
APIPLPVAGG
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]