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The map label for this gene is ribA [H]

Identifier: 154245981

GI number: 154245981

Start: 2296510

End: 2297622

Strand: Direct

Name: ribA [H]

Synonym: Xaut_2038

Alternate gene names: 154245981

Gene position: 2296510-2297622 (Clockwise)

Preceding gene: 154245976

Following gene: 154245982

Centisome position: 43.26

GC content: 71.79

Gene sequence:

>1113_bases
ATGACAACGGTGGTTGACGGTCTCGGTCTTGGCCGGGGCGCGGGAGAGATGGCGGTGGAGCGGGCGCTGGCGGAGCTGCG
GGCCGGCCGTGGCATGCGCGTGGCAGCAAACGGCACGGCGGTGCTGGTCATTGGCGCCGAGGCTTTCGATGCCGGAACTG
CCGCCGCCCTCACCGCTGCGGGGGCGCGCGACGCCCGCCTCGTGCTGCCGGCCCCACGCCTGCTGAAGCTGGGCGCGCCG
CGCGCTCAGGCCGGTTCGGTGTCCCTCCCGACCCTTGATGTGGAACGCGTCGCGGCCCTGGCGCTGCGCGTCGAGGCGCG
AGTGGATGCGCCGGTGGCGCCGGCCAATGCCTTCGACCACGCGGCGCTTGAGCTCTTGGGCCTCGCCTTGGTCCTGCCTG
CCGCCGTGGTGTGCGTGGTGCCTGAAGCGGCGGTTGCGGGCCTTCTCGCGGTGGATGCGGCGGACGTGATGGCCTATCGC
GCCGGGCAGGTGGCGCGGCTCGCCATCGTCGGGCGCGCGCCGGTGCCTTTGGAAGGCGCACCGGAGACGGAATTCGTGGT
GTTTCGTGGCGGCGAGGGCCTGCGCGACCAGGTGGCCATCGTGGTGGGCCGTCCGGACCTGTCCGCCCCGGTGGCGGTGC
GGCTGCATTCGGCCTGCCTCACCGGCGACCTGTTCGGCTCGCTGAAGTGCGATTGCGGCGACCAGCTGCGCGACAGCGTG
CGCCGCATGGCGGAAGGCGAGGGCGGCATCCTGCTTTATCTGGACCAGGAAGGGCGGGGCAACGGCATCTCCAACAAGAT
GCGCGCCTATGCCCTCCAGGCCCAGGGCTACGACACCTACGATGCGGACGCCGCACTGGGCTTCGACCTCGACCAGCGCC
GCTTCGACTTCGCCGCCGAGATGCTGCGCCAGCTTGGGGCGAAGGCGGTGCGGGTGTTCACCAACAATCCGCAGAAGATC
GCGGCGCTGAAGGCGGCGGGACTCGACGTGGTCTCCGACCAGCGGGTGCTGGGACGGCCCACCGCCGAGAATGTGCGCTA
CCTCGCCTCCAAGCGCGACCGCGCCGGCCACTACATCGATTTCGACGCCCTGGCCGCCCGCGCCCCGGACTGA

Upstream 100 bases:

>100_bases
GAGCAGGAACGCCATACGCCGTCGTTTGTTACGACCCTGCTGCGTTTGTGGATCTTTTTCTGGCGCATTGCGGCGCCGCC
TCTGCCTGTAAGGGGTCTTC

Downstream 100 bases:

>100_bases
CGCTTCGGCACGCGAAAAAAGCGGCCGGACTGGTTGTCGGGGTCGTTCGAAACGATTTAAAACCCCATCAGTCACGCACG
GCAAGACGTGGGACAGGATG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTTVVDGLGLGRGAGEMAVERALAELRAGRGMRVAANGTAVLVIGAEAFDAGTAAALTAAGARDARLVLPAPRLLKLGAP
RAQAGSVSLPTLDVERVAALALRVEARVDAPVAPANAFDHAALELLGLALVLPAAVVCVVPEAAVAGLLAVDAADVMAYR
AGQVARLAIVGRAPVPLEGAPETEFVVFRGGEGLRDQVAIVVGRPDLSAPVAVRLHSACLTGDLFGSLKCDCGDQLRDSV
RRMAEGEGGILLYLDQEGRGNGISNKMRAYALQAQGYDTYDADAALGFDLDQRRFDFAAEMLRQLGAKAVRVFTNNPQKI
AALKAAGLDVVSDQRVLGRPTAENVRYLASKRDRAGHYIDFDALAARAPD

Sequences:

>Translated_370_residues
MTTVVDGLGLGRGAGEMAVERALAELRAGRGMRVAANGTAVLVIGAEAFDAGTAAALTAAGARDARLVLPAPRLLKLGAP
RAQAGSVSLPTLDVERVAALALRVEARVDAPVAPANAFDHAALELLGLALVLPAAVVCVVPEAAVAGLLAVDAADVMAYR
AGQVARLAIVGRAPVPLEGAPETEFVVFRGGEGLRDQVAIVVGRPDLSAPVAVRLHSACLTGDLFGSLKCDCGDQLRDSV
RRMAEGEGGILLYLDQEGRGNGISNKMRAYALQAQGYDTYDADAALGFDLDQRRFDFAAEMLRQLGAKAVRVFTNNPQKI
AALKAAGLDVVSDQRVLGRPTAENVRYLASKRDRAGHYIDFDALAARAPD
>Mature_369_residues
TTVVDGLGLGRGAGEMAVERALAELRAGRGMRVAANGTAVLVIGAEAFDAGTAAALTAAGARDARLVLPAPRLLKLGAPR
AQAGSVSLPTLDVERVAALALRVEARVDAPVAPANAFDHAALELLGLALVLPAAVVCVVPEAAVAGLLAVDAADVMAYRA
GQVARLAIVGRAPVPLEGAPETEFVVFRGGEGLRDQVAIVVGRPDLSAPVAVRLHSACLTGDLFGSLKCDCGDQLRDSVR
RMAEGEGGILLYLDQEGRGNGISNKMRAYALQAQGYDTYDADAALGFDLDQRRFDFAAEMLRQLGAKAVRVFTNNPQKIA
ALKAAGLDVVSDQRVLGRPTAENVRYLASKRDRAGHYIDFDALAARAPD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=198, Percent_Identity=42.9292929292929, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319438, Length=132, Percent_Identity=37.8787878787879, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 38494; Mature: 38362

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVVDGLGLGRGAGEMAVERALAELRAGRGMRVAANGTAVLVIGAEAFDAGTAAALTAA
CCEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHC
GARDARLVLPAPRLLKLGAPRAQAGSVSLPTLDVERVAALALRVEARVDAPVAPANAFDH
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCHHH
AALELLGLALVLPAAVVCVVPEAAVAGLLAVDAADVMAYRAGQVARLAIVGRAPVPLEGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
PETEFVVFRGGEGLRDQVAIVVGRPDLSAPVAVRLHSACLTGDLFGSLKCDCGDQLRDSV
CCCCEEEEECCCCCCCEEEEEEECCCCCCCHHEEEHHHHHHHHHCCCEECCCCHHHHHHH
RRMAEGEGGILLYLDQEGRGNGISNKMRAYALQAQGYDTYDADAALGFDLDQRRFDFAAE
HHHHCCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHH
MLRQLGAKAVRVFTNNPQKIAALKAAGLDVVSDQRVLGRPTAENVRYLASKRDRAGHYID
HHHHHCCCEEEEEECCCHHEEHHHHCCCCEECCCHHHCCCCHHHHHHHHHCCCCCCCEEE
FDALAARAPD
HHHHHCCCCC
>Mature Secondary Structure 
TTVVDGLGLGRGAGEMAVERALAELRAGRGMRVAANGTAVLVIGAEAFDAGTAAALTAA
CEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHC
GARDARLVLPAPRLLKLGAPRAQAGSVSLPTLDVERVAALALRVEARVDAPVAPANAFDH
CCCCCEEEECCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCCCCCCHHH
AALELLGLALVLPAAVVCVVPEAAVAGLLAVDAADVMAYRAGQVARLAIVGRAPVPLEGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
PETEFVVFRGGEGLRDQVAIVVGRPDLSAPVAVRLHSACLTGDLFGSLKCDCGDQLRDSV
CCCCEEEEECCCCCCCEEEEEEECCCCCCCHHEEEHHHHHHHHHCCCEECCCCHHHHHHH
RRMAEGEGGILLYLDQEGRGNGISNKMRAYALQAQGYDTYDADAALGFDLDQRRFDFAAE
HHHHCCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHH
MLRQLGAKAVRVFTNNPQKIAALKAAGLDVVSDQRVLGRPTAENVRYLASKRDRAGHYID
HHHHHCCCEEEEEECCCHHEEHHHHCCCCEECCCHHHCCCCHHHHHHHHHCCCCCCCEEE
FDALAARAPD
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]