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The map label for this gene is bcr [C]

Identifier: 154245933

GI number: 154245933

Start: 2246903

End: 2248261

Strand: Direct

Name: bcr [C]

Synonym: Xaut_1990

Alternate gene names: 154245933

Gene position: 2246903-2248261 (Clockwise)

Preceding gene: 154245932

Following gene: 154245934

Centisome position: 42.32

GC content: 70.35

Gene sequence:

>1359_bases
ATGAGCGCCGTCCCGCACAGAACCGCCCCTGCGCCGGCCGTCGGGGTTTCGGCCGCGCCGCTCATGAGCGAGCGGGAAGT
GTCCGTCATCGGCGCGCTCATGGTGATGCTCGGCCCCATCAGCCTTGCCATGTATACGCCGGCGCTACCGACGCTGGTCG
AGGCCTTCGGCACCAGCATCGCCACGGTGAAGCTCACCCTCACCGTGTTCTTCATGGGCTTCGCCTTTTCCCAGCTGGTC
TGCGGCCCGCTCTCGGACGGCTACGGGCGGCGCCCGGTGGCTTTGGGCTTCTTCGGCATCTATCTCGCTGGCAGCGTCGT
CGCCATGCTGGCGCCCACCATCGGCTGGCTCATTGCAGGCCGCGCCCTGCAGGGCATCGGCTGTGCTGCCGGCATCGCCC
TGTCCCGCGCGCTGGTGCGCGACCAATATACCGGCCAGGCGTCGGCGCGGGTGATGAACCTCATCGGCACCATGCTGGCC
ATCGGCCCGGCGGTTTCGCCCACTCTGGGCGGGTTCATTCTCGGCACGGCGGGCTGGCATGTGATCTTCATCGCCATGGC
GGCCTATGGCCTCCTGCTGGTGGCGGTCCTCGCCCTTCGGGTGCCGGAGACCAACCGCTCGCCGGACCGCGGGCTGGCTT
CCCCCCGCGGAGTGACGACGAGCTATCGCCGGCTCCTCACCGACCGTGTGTTCATGCGCGCGGCGCTCACCGCCGGCCTC
AGCCTTGGCGGCATCTATACCCTCTCGGCGCTGCTGCCCTTCATTCTCATCCAGCGTGTGGGGCTCTCGCCCACCGGCTT
CGGCCTCGCCATGCTGTTGCAGACCGGTGCCTTCATGTCCGGCACCCTCATCGCCCGGCCGCTGCTGAAGCGCTACAGCG
CCCACGCCCTGATTCTGCCCGGCCTGTTGCTGGTGCTCACCGGGGCGGTGGGGCTGGGGCTGGGCCCGTTCGTGCTGCCG
TTGAGCGTCGCCAGCGTCATGCTGCCGATCTCGTTTTGGGCCTGCGGCGTCGCTTTGCTGCTGCCGGGCTGCACCACCGC
CGGCCTCGCCGGGTTCGCGCCCATCGCCGGGGCGGCCTCGGCGCTGATGGGCTTTCTCCAGATCGGCAGCGGCTTCCTCG
GCACTTCCTTCGCGGTGCTGTTTCCCTCGCCGCTGGTCGCCATGATGACGCTGCTGCCGGCCCTCGCCGTCACCGCCGCC
GGCGCCCACGTGTTGCTGGCTCCGCGCCGCGAGCCGGCCGTCGCAGTCGGGGCCGCTCCCGTCGAGGCCACCGACCTTGA
GCTGGCCGCCGATCCGCTCGGCGTGGTGGGCGCCGCCGGCGACGAAATCGAGTCCGGAACTTACGACAGGGCCTCATGA

Upstream 100 bases:

>100_bases
CCACCTGCGGCTTCACGGACGCCGAGCAGGCTCTGCTGCGGGACCTGCTGCTGCGGCTGCGCGACAACCTCGCGCGGGAG
CATCGCTTGAGGGACGAGAA

Downstream 100 bases:

>100_bases
GGCAATAGGTTACGGCTCCTCGATACCGTCCGCGCCACTCAGGTGATGTCGCAGGTTGACCCCGGCCGATCGGCAATGGT
CAATGCCCGCGTGCCCGAAC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSAVPHRTAPAPAVGVSAAPLMSEREVSVIGALMVMLGPISLAMYTPALPTLVEAFGTSIATVKLTLTVFFMGFAFSQLV
CGPLSDGYGRRPVALGFFGIYLAGSVVAMLAPTIGWLIAGRALQGIGCAAGIALSRALVRDQYTGQASARVMNLIGTMLA
IGPAVSPTLGGFILGTAGWHVIFIAMAAYGLLLVAVLALRVPETNRSPDRGLASPRGVTTSYRRLLTDRVFMRAALTAGL
SLGGIYTLSALLPFILIQRVGLSPTGFGLAMLLQTGAFMSGTLIARPLLKRYSAHALILPGLLLVLTGAVGLGLGPFVLP
LSVASVMLPISFWACGVALLLPGCTTAGLAGFAPIAGAASALMGFLQIGSGFLGTSFAVLFPSPLVAMMTLLPALAVTAA
GAHVLLAPRREPAVAVGAAPVEATDLELAADPLGVVGAAGDEIESGTYDRAS

Sequences:

>Translated_452_residues
MSAVPHRTAPAPAVGVSAAPLMSEREVSVIGALMVMLGPISLAMYTPALPTLVEAFGTSIATVKLTLTVFFMGFAFSQLV
CGPLSDGYGRRPVALGFFGIYLAGSVVAMLAPTIGWLIAGRALQGIGCAAGIALSRALVRDQYTGQASARVMNLIGTMLA
IGPAVSPTLGGFILGTAGWHVIFIAMAAYGLLLVAVLALRVPETNRSPDRGLASPRGVTTSYRRLLTDRVFMRAALTAGL
SLGGIYTLSALLPFILIQRVGLSPTGFGLAMLLQTGAFMSGTLIARPLLKRYSAHALILPGLLLVLTGAVGLGLGPFVLP
LSVASVMLPISFWACGVALLLPGCTTAGLAGFAPIAGAASALMGFLQIGSGFLGTSFAVLFPSPLVAMMTLLPALAVTAA
GAHVLLAPRREPAVAVGAAPVEATDLELAADPLGVVGAAGDEIESGTYDRAS
>Mature_451_residues
SAVPHRTAPAPAVGVSAAPLMSEREVSVIGALMVMLGPISLAMYTPALPTLVEAFGTSIATVKLTLTVFFMGFAFSQLVC
GPLSDGYGRRPVALGFFGIYLAGSVVAMLAPTIGWLIAGRALQGIGCAAGIALSRALVRDQYTGQASARVMNLIGTMLAI
GPAVSPTLGGFILGTAGWHVIFIAMAAYGLLLVAVLALRVPETNRSPDRGLASPRGVTTSYRRLLTDRVFMRAALTAGLS
LGGIYTLSALLPFILIQRVGLSPTGFGLAMLLQTGAFMSGTLIARPLLKRYSAHALILPGLLLVLTGAVGLGLGPFVLPL
SVASVMLPISFWACGVALLLPGCTTAGLAGFAPIAGAASALMGFLQIGSGFLGTSFAVLFPSPLVAMMTLLPALAVTAAG
AHVLLAPRREPAVAVGAAPVEATDLELAADPLGVVGAAGDEIESGTYDRAS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=359, Percent_Identity=29.2479108635098, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI48994889, Length=361, Percent_Identity=27.9778393351801, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790146, Length=338, Percent_Identity=27.810650887574, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87082312, Length=346, Percent_Identity=26.5895953757225, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790794, Length=312, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787065, Length=259, Percent_Identity=27.4131274131274, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081738, Length=196, Percent_Identity=33.6734693877551, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45967; Mature: 45836

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHCCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVPHRTAPAPAVGVSAAPLMSEREVSVIGALMVMLGPISLAMYTPALPTLVEAFGTSI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCH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CCCCCCHHCCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA