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The map label for this gene is paaE [H]

Identifier: 154244850

GI number: 154244850

Start: 1001813

End: 1002982

Strand: Direct

Name: paaE [H]

Synonym: Xaut_0900

Alternate gene names: 154244850

Gene position: 1001813-1002982 (Clockwise)

Preceding gene: 154244849

Following gene: 154244854

Centisome position: 18.87

GC content: 68.72

Gene sequence:

>1170_bases
ATGCCACTGACGGGTGACGCCATGGACAACGCGATCGACACCACCGCCGCTTCCGGCATCCCGTCCACCGGCGTGGGCGC
TGCTCCGAAGGGGGCGGGTACGCCGAAATTCCATCGCCTCGCCGTGCGCGAGGTGCGCCGCGAGACTATCGATGCGGTCT
CCATTACCTTCGAGGTGCCCTCCGCCCTTGCCGCCGATTTCGCCTTCGCCCCCGGCCAATACCTGACCCTGAAGGCGACG
ATGGAGGGCGAGGAGATCCGCCGCTCCTATTCCATCTGCTCCGGTCCGGATGACGGCGAGCTGCGCATCGCGGTGAAGCA
GGTGGAGGGCGGCCTGTTCTCCACCTGGGTCAATGAAAGCCTGAAGCCCGGCGACGAACTGGAGGTGATGACCCCCACCG
GCCGCTTCGGGCTGGAGCAGGCGCCGGGCAATGCCCGCATTCATGTGGCGTTCGCGGCGGGCTCGGGCATCACGCCGGTG
CTCTCCATCGCCCGCGGCGTGCTGGCGCGCGAGCCCGACAGCCGCTTCTTCCTGTTCTATGGCAACCGCTCCACCGACAA
CATCCTGTTCCGCACCGAGCTGGAGGAACTGAAGGACCGCTTCCTCGGCCGCCTGTCCGTGTTCCATGTGCTGTCGCGGG
AGCAGCAGGACCTTGCCATCCTCAACGGCCATCTGGACGGGGAGAAGGTGCGCCTTCTGCTCACCGCCATGGTGCCGGCG
GCGGCGGTGGACCATGCCTTCGTCTGCGGCCCCACCGCCATGATCGACGAGCTGGAGGCGACGCTCGCCGATCTCGGCCT
GCCGAAGGACAAGGTGCATGTGGAGCGCTTCGTCTCGGCGCTGGGCGGCAAGCCGCGCCCGAAGCCGGTGGTGGCGCCCG
ATGCCGCGCCGGCCCATGTGGCCTCCCTCATCGTGGACGGCAAGCGCCGCGACGTGCCGGTTGCCGAGGGCGAGGCCATC
CTCGACGCGGCGCTGCGGGCCGGCATGGACCTGCCTTTCGCCTGCAAGGGCGGCATGTGCTCCACCTGCCGCGCCAAGGT
GGTGGAAGGCGCGGCCGAGATGGAGGTGAATTATTCGCTGGAGCCGTGGGAGCTGGAAGCCGGCTTCATCCTCACCTGCC
AGGCCCGGCCCACCAGCGCGCGGGTGGTGGTGGATTTCGACCAGGTGTGA

Upstream 100 bases:

>100_bases
GCGGCTCCTCCGACACGGCGGAAATCGCGCCGTTCGGCTCCACCTCCTGCAAGTCCCTGTGGCAGTGCAAGGCCTGCCGC
GAGCCGTTCGATTATTTCAA

Downstream 100 bases:

>100_bases
GCGGGCGTTTGTAAATGCGCTCAAATGGGGGATTGCAGCCGTCGCAGGCGCATTATCACTGTCATGGCCGGGCTTGTCCC
GGCCATCCAAGCGGTGGGGC

Product: phenylacetate-CoA oxygenase/reductase subunit PaaK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPLTGDAMDNAIDTTAASGIPSTGVGAAPKGAGTPKFHRLAVREVRRETIDAVSITFEVPSALAADFAFAPGQYLTLKAT
MEGEEIRRSYSICSGPDDGELRIAVKQVEGGLFSTWVNESLKPGDELEVMTPTGRFGLEQAPGNARIHVAFAAGSGITPV
LSIARGVLAREPDSRFFLFYGNRSTDNILFRTELEELKDRFLGRLSVFHVLSREQQDLAILNGHLDGEKVRLLLTAMVPA
AAVDHAFVCGPTAMIDELEATLADLGLPKDKVHVERFVSALGGKPRPKPVVAPDAAPAHVASLIVDGKRRDVPVAEGEAI
LDAALRAGMDLPFACKGGMCSTCRAKVVEGAAEMEVNYSLEPWELEAGFILTCQARPTSARVVVDFDQV

Sequences:

>Translated_389_residues
MPLTGDAMDNAIDTTAASGIPSTGVGAAPKGAGTPKFHRLAVREVRRETIDAVSITFEVPSALAADFAFAPGQYLTLKAT
MEGEEIRRSYSICSGPDDGELRIAVKQVEGGLFSTWVNESLKPGDELEVMTPTGRFGLEQAPGNARIHVAFAAGSGITPV
LSIARGVLAREPDSRFFLFYGNRSTDNILFRTELEELKDRFLGRLSVFHVLSREQQDLAILNGHLDGEKVRLLLTAMVPA
AAVDHAFVCGPTAMIDELEATLADLGLPKDKVHVERFVSALGGKPRPKPVVAPDAAPAHVASLIVDGKRRDVPVAEGEAI
LDAALRAGMDLPFACKGGMCSTCRAKVVEGAAEMEVNYSLEPWELEAGFILTCQARPTSARVVVDFDQV
>Mature_388_residues
PLTGDAMDNAIDTTAASGIPSTGVGAAPKGAGTPKFHRLAVREVRRETIDAVSITFEVPSALAADFAFAPGQYLTLKATM
EGEEIRRSYSICSGPDDGELRIAVKQVEGGLFSTWVNESLKPGDELEVMTPTGRFGLEQAPGNARIHVAFAAGSGITPVL
SIARGVLAREPDSRFFLFYGNRSTDNILFRTELEELKDRFLGRLSVFHVLSREQQDLAILNGHLDGEKVRLLLTAMVPAA
AVDHAFVCGPTAMIDELEATLADLGLPKDKVHVERFVSALGGKPRPKPVVAPDAAPAHVASLIVDGKRRDVPVAEGEAIL
DAALRAGMDLPFACKGGMCSTCRAKVVEGAAEMEVNYSLEPWELEAGFILTCQARPTSARVVVDFDQV

Specific function: May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=226, Percent_Identity=26.5486725663717, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI284448553, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI6552328, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI193794826, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI284448551, Length=245, Percent_Identity=27.3469387755102, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4503327, Length=245, Percent_Identity=27.3469387755102, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787658, Length=353, Percent_Identity=47.5920679886686, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1787098, Length=341, Percent_Identity=25.2199413489736, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788104, Length=326, Percent_Identity=26.3803680981595, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788903, Length=215, Percent_Identity=28.8372093023256, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790359, Length=229, Percent_Identity=27.5109170305677, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17563926, Length=211, Percent_Identity=28.9099526066351, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322146, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322699, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=201, Percent_Identity=27.8606965174129, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007806, Length=231, Percent_Identity=25.974025974026, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007804, Length=231, Percent_Identity=25.974025974026, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366101, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24662934, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24662938, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR011884
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 41567; Mature: 41436

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTGDAMDNAIDTTAASGIPSTGVGAAPKGAGTPKFHRLAVREVRRETIDAVSITFEVP
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECC
SALAADFAFAPGQYLTLKATMEGEEIRRSYSICSGPDDGELRIAVKQVEGGLFSTWVNES
HHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHCC
LKPGDELEVMTPTGRFGLEQAPGNARIHVAFAAGSGITPVLSIARGVLAREPDSRFFLFY
CCCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
GNRSTDNILFRTELEELKDRFLGRLSVFHVLSREQQDLAILNGHLDGEKVRLLLTAMVPA
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEHHHHHHHH
AAVDHAFVCGPTAMIDELEATLADLGLPKDKVHVERFVSALGGKPRPKPVVAPDAAPAHV
HHHCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHH
ASLIVDGKRRDVPVAEGEAILDAALRAGMDLPFACKGGMCSTCRAKVVEGAAEMEVNYSL
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHEEEECCC
EPWELEAGFILTCQARPTSARVVVDFDQV
CCEEECCCEEEEEECCCCCCEEEEEECCC
>Mature Secondary Structure 
PLTGDAMDNAIDTTAASGIPSTGVGAAPKGAGTPKFHRLAVREVRRETIDAVSITFEVP
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECC
SALAADFAFAPGQYLTLKATMEGEEIRRSYSICSGPDDGELRIAVKQVEGGLFSTWVNES
HHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHCC
LKPGDELEVMTPTGRFGLEQAPGNARIHVAFAAGSGITPVLSIARGVLAREPDSRFFLFY
CCCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
GNRSTDNILFRTELEELKDRFLGRLSVFHVLSREQQDLAILNGHLDGEKVRLLLTAMVPA
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEHHHHHHHH
AAVDHAFVCGPTAMIDELEATLADLGLPKDKVHVERFVSALGGKPRPKPVVAPDAAPAHV
HHHCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCHHHH
ASLIVDGKRRDVPVAEGEAILDAALRAGMDLPFACKGGMCSTCRAKVVEGAAEMEVNYSL
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHEEEECCC
EPWELEAGFILTCQARPTSARVVVDFDQV
CCEEECCCEEEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]