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The map label for this gene is fadA [H]

Identifier: 154244577

GI number: 154244577

Start: 701220

End: 702356

Strand: Reverse

Name: fadA [H]

Synonym: Xaut_0625

Alternate gene names: 154244577

Gene position: 702356-701220 (Counterclockwise)

Preceding gene: 154244579

Following gene: 154244576

Centisome position: 13.23

GC content: 71.33

Gene sequence:

>1137_bases
ATGGCCCACGCTTTCATCGTCGATTACGCGCGCAGCCCCTTCGCCCCGGCCTACAAGGGCGCCCTCGCGGGCATCCGCCC
GGACGACCTTGCCGCCGGTGTCATCTCCACCGTCGTCGGCCGCTCGGGCCTCGATCCCGCGACCCTCGAGGACGTTATCC
TCGGCTGCGCCTTCGCGGAGGGGGAGCAGGGCCTCAATATCGCCCGCTGCGCCAGCCTCATCGCCGGCCTGCCGCTGAGC
GTCGGTGGCTCCACGGTGAACCGCTGGTGCGGCTCCTCCATGCAGGCGGTCCAGATGGCCACGGGCGCCATCGCCATGGG
AGCAGGCGAGGCCTTCATCGCCGGCGGCATCGAGAGCATGACCAAGGTGCCCATGATGGGCTTCAACCCCATGCCCAATC
CGCGCTGGGACGATGCCCTGCGCGCCGCATTCCTGAACATGGGCCTCACCGCCGAAAATCTCGCTGACCGTTACGCCATC
TCCCGCGAGGCCCAGGACACCTATGCCGCCGCGAGCCAGGACAAGGCCGCCACAGCGCAGGCCGATGGGCGCCTCGCCGC
CGAGATCGCACCGGTGGCGACGTCGGCCGGGGCGGTGGACAAGGACGGCTGCGTGCGCGGCGGCACCACCGTCGACAAGC
TCGGGGCCCTCAAGGCGGTGTTCAAGGCGGGGGGCTCGGTCACGGCTGGCAATTCCTCTCCGCTGACCGATGGCGCCTCG
GCGACCCTGATCGTCTCCGAGGATTTCGCCCGCCGGCACAATCTCGCGCCGCTGGCGCGGGTGGCGGGCTATGCGGTGTC
CGGCTGCGCGCCCGAGATCATGGGTATCGGCCCGGTGGAGGCCACCCGCAAGGCCCTCGCCCGCGCCGACATCACGGCGG
CCGACCTCGACGTGATCGAGATGAACGAGGCGTTCGCGGTCCAGGTGCTGGCCTGCTGCGCTGACCTCGACATCGATCCC
GCCCGTCTCAATCGCGACGGTGGCGCCATCGCGCTGGGCCATCCGCTGGGCGCCACCGGCGCGCGCCTGGTGGGCAAGGC
GGCGCAGCTCCTGAAGCGCGACGGCGGGCGCTATGGCCTTGCCACCCAGTGTATCGGCGGCGGGCAGGGCATCGCCCTCG
TGCTGGAGGCCGCGTGA

Upstream 100 bases:

>100_bases
CGGTCGAACCGGATCACCCCCCTCCCCTGCCGACACGACCTCTTGTCCTGCACTGCCTCCAGCGAACCCGTGCCGGCGTC
GGGCCGGCCAAGGAACGAGC

Downstream 100 bases:

>100_bases
TGGGCCAGATCCGCAAGACCGGCGTCATCGGCGCCGGCGTCATGGGATCGGGCATCGCCGCCCACCTCGCCAATGCCGGG
CTCGACGTGGTGCTGCTGGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MAHAFIVDYARSPFAPAYKGALAGIRPDDLAAGVISTVVGRSGLDPATLEDVILGCAFAEGEQGLNIARCASLIAGLPLS
VGGSTVNRWCGSSMQAVQMATGAIAMGAGEAFIAGGIESMTKVPMMGFNPMPNPRWDDALRAAFLNMGLTAENLADRYAI
SREAQDTYAAASQDKAATAQADGRLAAEIAPVATSAGAVDKDGCVRGGTTVDKLGALKAVFKAGGSVTAGNSSPLTDGAS
ATLIVSEDFARRHNLAPLARVAGYAVSGCAPEIMGIGPVEATRKALARADITAADLDVIEMNEAFAVQVLACCADLDIDP
ARLNRDGGAIALGHPLGATGARLVGKAAQLLKRDGGRYGLATQCIGGGQGIALVLEAA

Sequences:

>Translated_378_residues
MAHAFIVDYARSPFAPAYKGALAGIRPDDLAAGVISTVVGRSGLDPATLEDVILGCAFAEGEQGLNIARCASLIAGLPLS
VGGSTVNRWCGSSMQAVQMATGAIAMGAGEAFIAGGIESMTKVPMMGFNPMPNPRWDDALRAAFLNMGLTAENLADRYAI
SREAQDTYAAASQDKAATAQADGRLAAEIAPVATSAGAVDKDGCVRGGTTVDKLGALKAVFKAGGSVTAGNSSPLTDGAS
ATLIVSEDFARRHNLAPLARVAGYAVSGCAPEIMGIGPVEATRKALARADITAADLDVIEMNEAFAVQVLACCADLDIDP
ARLNRDGGAIALGHPLGATGARLVGKAAQLLKRDGGRYGLATQCIGGGQGIALVLEAA
>Mature_377_residues
AHAFIVDYARSPFAPAYKGALAGIRPDDLAAGVISTVVGRSGLDPATLEDVILGCAFAEGEQGLNIARCASLIAGLPLSV
GGSTVNRWCGSSMQAVQMATGAIAMGAGEAFIAGGIESMTKVPMMGFNPMPNPRWDDALRAAFLNMGLTAENLADRYAIS
REAQDTYAAASQDKAATAQADGRLAAEIAPVATSAGAVDKDGCVRGGTTVDKLGALKAVFKAGGSVTAGNSSPLTDGASA
TLIVSEDFARRHNLAPLARVAGYAVSGCAPEIMGIGPVEATRKALARADITAADLDVIEMNEAFAVQVLACCADLDIDPA
RLNRDGGAIALGHPLGATGARLVGKAAQLLKRDGGRYGLATQCIGGGQGIALVLEAA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=39.5886889460154, Blast_Score=267, Evalue=9e-72,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=40.3061224489796, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI148539872, Length=388, Percent_Identity=37.6288659793814, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=34.0153452685422, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=33.6492890995261, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI194353979, Length=385, Percent_Identity=32.4675324675325, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=45.5, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994986, Length=392, Percent_Identity=44.6428571428571, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=42.2391857506361, Blast_Score=258, Evalue=3e-70,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=40.9669211195929, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=33.0985915492958, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=37.8865979381443, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=35.3846153846154, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=33.9331619537275, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.8604651162791, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=383, Percent_Identity=28.1984334203655, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=380, Percent_Identity=35, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=34.3358395989975, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=43.2225063938619, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=38.7179487179487, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=33.9240506329114, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17137578, Length=420, Percent_Identity=30.4761904761905, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 38201; Mature: 38070

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAFIVDYARSPFAPAYKGALAGIRPDDLAAGVISTVVGRSGLDPATLEDVILGCAFAE
CCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GEQGLNIARCASLIAGLPLSVGGSTVNRWCGSSMQAVQMATGAIAMGAGEAFIAGGIESM
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCEEEECCCCHHHHCCHHHH
TKVPMMGFNPMPNPRWDDALRAAFLNMGLTAENLADRYAISREAQDTYAAASQDKAATAQ
HHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ADGRLAAEIAPVATSAGAVDKDGCVRGGTTVDKLGALKAVFKAGGSVTAGNSSPLTDGAS
CCCCEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
ATLIVSEDFARRHNLAPLARVAGYAVSGCAPEIMGIGPVEATRKALARADITAADLDVIE
EEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHCCCHHCCCEEE
MNEAFAVQVLACCADLDIDPARLNRDGGAIALGHPLGATGARLVGKAAQLLKRDGGRYGL
CCHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
ATQCIGGGQGIALVLEAA
HHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
AHAFIVDYARSPFAPAYKGALAGIRPDDLAAGVISTVVGRSGLDPATLEDVILGCAFAE
CCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GEQGLNIARCASLIAGLPLSVGGSTVNRWCGSSMQAVQMATGAIAMGAGEAFIAGGIESM
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCEEEECCCCHHHHCCHHHH
TKVPMMGFNPMPNPRWDDALRAAFLNMGLTAENLADRYAISREAQDTYAAASQDKAATAQ
HHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ADGRLAAEIAPVATSAGAVDKDGCVRGGTTVDKLGALKAVFKAGGSVTAGNSSPLTDGAS
CCCCEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
ATLIVSEDFARRHNLAPLARVAGYAVSGCAPEIMGIGPVEATRKALARADITAADLDVIE
EEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHCCCHHCCCEEE
MNEAFAVQVLACCADLDIDPARLNRDGGAIALGHPLGATGARLVGKAAQLLKRDGGRYGL
CCHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
ATQCIGGGQGIALVLEAA
HHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]