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The map label for this gene is guaA

Identifier: 154244402

GI number: 154244402

Start: 487173

End: 488747

Strand: Reverse

Name: guaA

Synonym: Xaut_0445

Alternate gene names: 154244402

Gene position: 488747-487173 (Counterclockwise)

Preceding gene: 154244403

Following gene: 154244401

Centisome position: 9.21

GC content: 68.51

Gene sequence:

>1575_bases
ATGTCCTCCCCCGCTCTGGATACTGCCGCCCAGGAAACCGTCCTCATCATCGATTTCGGCAGCCAGGTGACCCAGCTCAT
CGCCCGGCGGGTGCGCGAGGAAGGGGTCTATTCCGAGGTGGTGCCGTTCCAGAAGGGCGCCGAAGCCATCCAGCGGCTGA
AGCCTAAGGCCATCATCCTCTCCGGAGGCCCCGCCTCCGTCATCGAGGGCCAGAGCCCTAAGGCGCCCGAAGAAGCCTTC
GCCGCCGGCGTGCCGGTGCTCGGCATCTGCTACGGCGAGCAGTGCATGGCGGCCCAGCTGGGAGGCGCGGTGGAGGCGGG
CCACCATCGCGAGTTCGGCCGCGCCGAGCTGACCGTCCAGAAGGTGGTGCCTCTGTTCGAGGGCGTCTGGCGCGCGGGCG
AGCGCCACACGGTGTGGATGAGCCACGGCGATCGCGTCACCGCCCTGCCCGAGGGCTTCGAGGTGGTGGCCACCTCCGAC
AACGCCCCCTTCGCCGCCATCGCCGACCTGTCGCGCAACTATTACGGCGTGCAGTTCCACCCCGAGGTGGTGCACACCCC
GGACGGCGCACGGCTGCTCTCCAATTTCGTGCGCAAGGTGGCGAAGCTCGAGGGCGCCTGGACCATGGGCGCCTTCCGCG
AGCGCGCCATCGCCCGCATCCGCGAGCAGGTGGGCACGGGGCGCGTCATCTGCGGCCTGTCCGGCGGCGTGGATTCGTCC
GTTGCGGCTGTGCTCATCCACGAGGCCATCGGCGACCAGCTCACCTGTGTGTTCGTGGACCACGGCCTGATGCGCCAGGC
CGAGGCCGACGAGGTGGTTTCGCTGTTCCGCGGCCACTACAACATCCCGCTGGTGCATGTGGACGCCTCCGAGCTGTTCC
TGAAGGAGCTGGAGGGCGTCGAGGATCCCGAGGCCAAGCGCAAGACCATCGGCCGGCTGTTCATCGACGTGTTCGATGCC
GAGGCCAGGAAGGTGGGCGGCGCCGATTTCCTCGCCCAGGGCACGCTCTATCCCGACGTGATCGAGAGCGTCTCGTTCGC
CGGCGGCCCCTCGGTGACCATCAAGAGCCACCACAATGTGGGCGGCCTGCCCGAGCGCATGAACATGAAGCTGGTGGAGC
CCCTGCGCGACCTGTTCAAGGACGAGGTGCGCGCGCTCGGCCGCGAGCTCGGCCTGCCCGAGAGCTTCGTGGGCCGCCAC
CCCTTCCCCGGCCCCGGCCTCGCCATCCGCTGCCCGGGCGCCATCACCCGCGAGAAGCTGGACATCCTGCGCAAGGCCGA
CGCCATCTATCTGGAAGAGATCCGCTATGCCGGCCTCTACGACGTGATCTGGCAGGCCTTTGCCGTGCTGCTCCCGGTGC
GCACCGTGGGCGTGATGGGCGACGGCCGCACCTACGACCACGTCCTCGCCCTGCGCGCGGTGACCTCCGTGGACGGCATG
ACCGCCGACTTCTACCCCTTCGACATGGGCTTCCTCGGCCGCACCGCTACACGCATCATCAACGAGGTAAAGGGCGTCAA
CCGCGTGGTCTACGACGTCACCAGCAAGCCCCCGGGAACAATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GGCGCAAGGCCGGCCTGCGCCGGCCTTGACTTTTTAAATGGCCGCTTTGCCGCTAAAGGAGGGCGCAACATTTCCTCCTT
CGCGCGCAAGGTGCCCCTTC

Downstream 100 bases:

>100_bases
ACTAGGGTGGTTTCAGACCATCCCGCGCCGTGCCGAAGATCGAACCAACCATCTGGCTAACAACGATTTTTCTTCCTACC
CCGTATCACTGCGTTTCACC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSSPALDTAAQETVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKGAEAIQRLKPKAIILSGGPASVIEGQSPKAPEEAF
AAGVPVLGICYGEQCMAAQLGGAVEAGHHREFGRAELTVQKVVPLFEGVWRAGERHTVWMSHGDRVTALPEGFEVVATSD
NAPFAAIADLSRNYYGVQFHPEVVHTPDGARLLSNFVRKVAKLEGAWTMGAFRERAIARIREQVGTGRVICGLSGGVDSS
VAAVLIHEAIGDQLTCVFVDHGLMRQAEADEVVSLFRGHYNIPLVHVDASELFLKELEGVEDPEAKRKTIGRLFIDVFDA
EARKVGGADFLAQGTLYPDVIESVSFAGGPSVTIKSHHNVGGLPERMNMKLVEPLRDLFKDEVRALGRELGLPESFVGRH
PFPGPGLAIRCPGAITREKLDILRKADAIYLEEIRYAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSVDGM
TADFYPFDMGFLGRTATRIINEVKGVNRVVYDVTSKPPGTIEWE

Sequences:

>Translated_524_residues
MSSPALDTAAQETVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKGAEAIQRLKPKAIILSGGPASVIEGQSPKAPEEAF
AAGVPVLGICYGEQCMAAQLGGAVEAGHHREFGRAELTVQKVVPLFEGVWRAGERHTVWMSHGDRVTALPEGFEVVATSD
NAPFAAIADLSRNYYGVQFHPEVVHTPDGARLLSNFVRKVAKLEGAWTMGAFRERAIARIREQVGTGRVICGLSGGVDSS
VAAVLIHEAIGDQLTCVFVDHGLMRQAEADEVVSLFRGHYNIPLVHVDASELFLKELEGVEDPEAKRKTIGRLFIDVFDA
EARKVGGADFLAQGTLYPDVIESVSFAGGPSVTIKSHHNVGGLPERMNMKLVEPLRDLFKDEVRALGRELGLPESFVGRH
PFPGPGLAIRCPGAITREKLDILRKADAIYLEEIRYAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSVDGM
TADFYPFDMGFLGRTATRIINEVKGVNRVVYDVTSKPPGTIEWE
>Mature_523_residues
SSPALDTAAQETVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKGAEAIQRLKPKAIILSGGPASVIEGQSPKAPEEAFA
AGVPVLGICYGEQCMAAQLGGAVEAGHHREFGRAELTVQKVVPLFEGVWRAGERHTVWMSHGDRVTALPEGFEVVATSDN
APFAAIADLSRNYYGVQFHPEVVHTPDGARLLSNFVRKVAKLEGAWTMGAFRERAIARIREQVGTGRVICGLSGGVDSSV
AAVLIHEAIGDQLTCVFVDHGLMRQAEADEVVSLFRGHYNIPLVHVDASELFLKELEGVEDPEAKRKTIGRLFIDVFDAE
ARKVGGADFLAQGTLYPDVIESVSFAGGPSVTIKSHHNVGGLPERMNMKLVEPLRDLFKDEVRALGRELGLPESFVGRHP
FPGPGLAIRCPGAITREKLDILRKADAIYLEEIRYAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSVDGMT
ADFYPFDMGFLGRTATRIINEVKGVNRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=37.3406193078324, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=56.0693641618497, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1789760, Length=152, Percent_Identity=30.9210526315789, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=38.1034482758621, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=38.1034482758621, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI133901714, Length=582, Percent_Identity=38.1443298969072, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=52.6011560693642, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=35.8181818181818, Blast_Score=281, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57007; Mature: 56876

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPALDTAAQETVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKGAEAIQRLKPKAIIL
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCEEEE
SGGPASVIEGQSPKAPEEAFAAGVPVLGICYGEQCMAAQLGGAVEAGHHREFGRAELTVQ
CCCCCHHCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHH
KVVPLFEGVWRAGERHTVWMSHGDRVTALPEGFEVVATSDNAPFAAIADLSRNYYGVQFH
HHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHCCCEEEEEEC
PEVVHTPDGARLLSNFVRKVAKLEGAWTMGAFRERAIARIREQVGTGRVICGLSGGVDSS
CCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VAAVLIHEAIGDQLTCVFVDHGLMRQAEADEVVSLFRGHYNIPLVHVDASELFLKELEGV
HHHHHHHHHHCCCEEEEEECCCHHHHCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCC
EDPEAKRKTIGRLFIDVFDAEARKVGGADFLAQGTLYPDVIESVSFAGGPSVTIKSHHNV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCC
GGLPERMNMKLVEPLRDLFKDEVRALGRELGLPESFVGRHPFPGPGLAIRCPGAITREKL
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCHHHHHH
DILRKADAIYLEEIRYAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSVDGM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCC
TADFYPFDMGFLGRTATRIINEVKGVNRVVYDVTSKPPGTIEWE
CCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SSPALDTAAQETVLIIDFGSQVTQLIARRVREEGVYSEVVPFQKGAEAIQRLKPKAIIL
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCEEEE
SGGPASVIEGQSPKAPEEAFAAGVPVLGICYGEQCMAAQLGGAVEAGHHREFGRAELTVQ
CCCCCHHCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHH
KVVPLFEGVWRAGERHTVWMSHGDRVTALPEGFEVVATSDNAPFAAIADLSRNYYGVQFH
HHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEECCCCCCHHHHHHCCCEEEEEEC
PEVVHTPDGARLLSNFVRKVAKLEGAWTMGAFRERAIARIREQVGTGRVICGLSGGVDSS
CCEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHH
VAAVLIHEAIGDQLTCVFVDHGLMRQAEADEVVSLFRGHYNIPLVHVDASELFLKELEGV
HHHHHHHHHHCCCEEEEEECCCHHHHCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCC
EDPEAKRKTIGRLFIDVFDAEARKVGGADFLAQGTLYPDVIESVSFAGGPSVTIKSHHNV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCCCCCEEEEECCCCC
GGLPERMNMKLVEPLRDLFKDEVRALGRELGLPESFVGRHPFPGPGLAIRCPGAITREKL
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCHHHHHH
DILRKADAIYLEEIRYAGLYDVIWQAFAVLLPVRTVGVMGDGRTYDHVLALRAVTSVDGM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCC
TADFYPFDMGFLGRTATRIINEVKGVNRVVYDVTSKPPGTIEWE
CCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA