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The map label for this gene is tetA [H]

Identifier: 154244381

GI number: 154244381

Start: 456169

End: 457380

Strand: Reverse

Name: tetA [H]

Synonym: Xaut_0424

Alternate gene names: 154244381

Gene position: 457380-456169 (Counterclockwise)

Preceding gene: 154244382

Following gene: 154244373

Centisome position: 8.62

GC content: 69.31

Gene sequence:

>1212_bases
ATGATCGCGCTCTATCTGCTGATCCTGGTGGATTCCATCAGCGCGACCGTCATCATCCCGCTGCTCGGTCCGCTGCTGAT
CGACCCGGCGACGCTGGTGTTCCTGCCCGATGCGTCGCTGCCCCTGCGCAATTTCGTCAGCGGGCTGCTGGTGGCGACCT
ACGTCCTGCTGATGCTGTACATGGCGCCGGTGCTGGGGCGCCTGTCGGACCAATGGGGCCGCCGGCCGGTGCTGCTGCTG
TGCGGTGCTGGCGTGCTGCTGGGCAATCTTCTGGCCGGCCTCGCCATCGACCTGCACCTGCTGCCGCTGCTGTTCCTCGG
CCGGTTCATCGGCGGCGCCACCGCCGCCGCCCAGCCCACGGCGCAGGCGGCGCTGGTGGATACCGGCAGCAACAAGGCCC
GGCTTTTGAGCTACAGCATGCTGTTCTCCTCGCTCGGCTTCGTGCTCGGTCCGGTGGTGGCCTCCGGCCTGTCCACCCTC
TCCTTCTCCGCGCCGCTGCACCTGTGCACGGCGCTGACGCTCGTCGCCCTGGTGCTGCTGTGGACCGGCTACCGGGAGGA
AGAGAAGCCCGGGCGAAAGGTGGACTGGTCCACCATCTCCATCTTCGAGGGCGTGCGCTGCTTCCGGGAGGCGGCGGGCG
ACAAGGCGGTGCGCGGCATCCTCGGCGGCTTCCTGCTGATGCAGGTGGCGTGGGGCAGCTTCTTCGTCTTCGTCTCGGTC
TATCTCATGGCCGCGCCCGGACTGCGGCTGAGCCTGCATCAGGTGGGCGCCTTCATGTCCATCATGGGGATCGGCTTCTG
CATCTCCAACGCGCTGGTGCAGCCGGCCCTGTCCGAGCGCTTCGGCATGCGCAGCCTCGCGGTGGCCGGGCTCGCCCTGA
ATGCGACCACCATGGTGGCGTGCCTGCTGCTGGGTTCGGCCTATCAGGCCTATGCGGCGGCGTTGATCGCCGGCATCACC
GTCAACATCGCCTACCCCTCCATCGTCACCATGCTGTCGGATCGCGTGGCGCCGGAGCGACAGGGCTGGATCCTGGGCAT
GGTCGGCTCGGCGGCGGCCATGGGGTGGGGGATTTCCTCAGTGGTCTCCGGCGCGCTGGGCGGCCTCGGGCAGGCCCTGC
CGGTGGTGCTGGCAGCAGCGCTGATGGCGACCGCCGCCCTCGCCATGACCGTGGCGGGCTCCGGCAGGACGATGGCCGAC
GCGCCGGACTGA

Upstream 100 bases:

>100_bases
ACTACAAGGAAGAAACCATCCGCGGCCTGGCCGACCGGATGCGGGAGAGCCTGAAGGCGCACCTAAACGACCCCGTCGCA
GCTCCGGTCGCCGCGCCGGC

Downstream 100 bases:

>100_bases
GACCAACTGTGATCGGGCGTGACGCGCGGGCCTTCGATCAGGCCCGCGCGTCGGTCGAGGGGCGAAATCGGCAAGCCTCA
ATCGCCCTCATGCCGCACCT

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MIALYLLILVDSISATVIIPLLGPLLIDPATLVFLPDASLPLRNFVSGLLVATYVLLMLYMAPVLGRLSDQWGRRPVLLL
CGAGVLLGNLLAGLAIDLHLLPLLFLGRFIGGATAAAQPTAQAALVDTGSNKARLLSYSMLFSSLGFVLGPVVASGLSTL
SFSAPLHLCTALTLVALVLLWTGYREEEKPGRKVDWSTISIFEGVRCFREAAGDKAVRGILGGFLLMQVAWGSFFVFVSV
YLMAAPGLRLSLHQVGAFMSIMGIGFCISNALVQPALSERFGMRSLAVAGLALNATTMVACLLLGSAYQAYAAALIAGIT
VNIAYPSIVTMLSDRVAPERQGWILGMVGSAAAMGWGISSVVSGALGGLGQALPVVLAAALMATAALAMTVAGSGRTMAD
APD

Sequences:

>Translated_403_residues
MIALYLLILVDSISATVIIPLLGPLLIDPATLVFLPDASLPLRNFVSGLLVATYVLLMLYMAPVLGRLSDQWGRRPVLLL
CGAGVLLGNLLAGLAIDLHLLPLLFLGRFIGGATAAAQPTAQAALVDTGSNKARLLSYSMLFSSLGFVLGPVVASGLSTL
SFSAPLHLCTALTLVALVLLWTGYREEEKPGRKVDWSTISIFEGVRCFREAAGDKAVRGILGGFLLMQVAWGSFFVFVSV
YLMAAPGLRLSLHQVGAFMSIMGIGFCISNALVQPALSERFGMRSLAVAGLALNATTMVACLLLGSAYQAYAAALIAGIT
VNIAYPSIVTMLSDRVAPERQGWILGMVGSAAAMGWGISSVVSGALGGLGQALPVVLAAALMATAALAMTVAGSGRTMAD
APD
>Mature_403_residues
MIALYLLILVDSISATVIIPLLGPLLIDPATLVFLPDASLPLRNFVSGLLVATYVLLMLYMAPVLGRLSDQWGRRPVLLL
CGAGVLLGNLLAGLAIDLHLLPLLFLGRFIGGATAAAQPTAQAALVDTGSNKARLLSYSMLFSSLGFVLGPVVASGLSTL
SFSAPLHLCTALTLVALVLLWTGYREEEKPGRKVDWSTISIFEGVRCFREAAGDKAVRGILGGFLLMQVAWGSFFVFVSV
YLMAAPGLRLSLHQVGAFMSIMGIGFCISNALVQPALSERFGMRSLAVAGLALNATTMVACLLLGSAYQAYAAALIAGIT
VNIAYPSIVTMLSDRVAPERQGWILGMVGSAAAMGWGISSVVSGALGGLGQALPVVLAAALMATAALAMTVAGSGRTMAD
APD

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41827; Mature: 41827

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALYLLILVDSISATVIIPLLGPLLIDPATLVFLPDASLPLRNFVSGLLVATYVLLMLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
MAPVLGRLSDQWGRRPVLLLCGAGVLLGNLLAGLAIDLHLLPLLFLGRFIGGATAAAQPT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQAALVDTGSNKARLLSYSMLFSSLGFVLGPVVASGLSTLSFSAPLHLCTALTLVALVLL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WTGYREEEKPGRKVDWSTISIFEGVRCFREAAGDKAVRGILGGFLLMQVAWGSFFVFVSV
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLMAAPGLRLSLHQVGAFMSIMGIGFCISNALVQPALSERFGMRSLAVAGLALNATTMVA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
CLLLGSAYQAYAAALIAGITVNIAYPSIVTMLSDRVAPERQGWILGMVGSAAAMGWGISS
HHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCHHH
VVSGALGGLGQALPVVLAAALMATAALAMTVAGSGRTMADAPD
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIALYLLILVDSISATVIIPLLGPLLIDPATLVFLPDASLPLRNFVSGLLVATYVLLMLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
MAPVLGRLSDQWGRRPVLLLCGAGVLLGNLLAGLAIDLHLLPLLFLGRFIGGATAAAQPT
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQAALVDTGSNKARLLSYSMLFSSLGFVLGPVVASGLSTLSFSAPLHLCTALTLVALVLL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WTGYREEEKPGRKVDWSTISIFEGVRCFREAAGDKAVRGILGGFLLMQVAWGSFFVFVSV
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLMAAPGLRLSLHQVGAFMSIMGIGFCISNALVQPALSERFGMRSLAVAGLALNATTMVA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
CLLLGSAYQAYAAALIAGITVNIAYPSIVTMLSDRVAPERQGWILGMVGSAAAMGWGISS
HHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCHHH
VVSGALGGLGQALPVVLAAALMATAALAMTVAGSGRTMADAPD
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]