Click here to switch to the map view.

The map label for this gene is acoB [H]

Identifier: 153937737

GI number: 153937737

Start: 1740217

End: 1741188

Strand: Direct

Name: acoB [H]

Synonym: CLC_1657

Alternate gene names: 153937737

Gene position: 1740217-1741188 (Clockwise)

Preceding gene: 153936990

Following gene: 153934661

Centisome position: 46.28

GC content: 36.73

Gene sequence:

>972_bases
ATGAAAAAGTTAACATACGCAGAAGCAATAAGAGAAGCAATGAGAACTAAAATGAGTGAAGATGATAAGGTATTAATTTT
TGGGGAAGACGTAGGAGCTTTTGGAGGATGCTTTGGAGTAACCGGAGATTTATACAAAGAATTTGGAGATAAAAGAGTAA
GAGATACTCCTATATCTGAAGGCGCAATTGCAGGATGTGCTGTTGGAGCAGCAGCTACGGGTCTAAGACCAATTGCAGAG
ATAATGTTTGGGGACTTTTTAACGGTGTCAATGGATATGATCGTAAATCAAGCTGCAAAAATGAGATTTATGTTTGGGGG
AAAGATAAGTTTACCTATGGTAGTTAGATTACCAGAGGGAGCAGGTGTACAAGCAGCTGCACAGCATTCTCAATCCCTTG
AAGCTTGGCTTACACATGTGCCAGGTCTTAAAGTGGTATATCCATCCACACCACAGGATGCATATGGACTTATGGTAGCA
GCTATAGAGGATGATAACCCAGTTATGTTTATGGAACACAAATTTTTATATGGCATGAAGGGTGAAGTTTCAGATGAAAT
AAAAAGAATACCTTTAGGTGTGGCAGATATTAAAAGAGAAGGAAAGGATGTCACTATTATAGCTACAGGTAAAATGGTAC
ACGAATCTTTAAAAGCAGCAGATATACTTTCAAAGGATGGGATTGAAGTAGAAGTGATAGATCCAAGAACTTTATATCCA
CTAGATAAGGAAACTATATTTAATTCTATAAAGAAAACCAATAGAGCTGTAGTTGTAACAGAGGAAAATAAAAGAGGAGC
CTATAGTGGAGAAATATCTTCCCTAATAAATGAGGAGATTTTCGATTATTTGGATGCACCTGTAGGCAGAATAGGAGCCC
TTAATACTCCTATACCATTTTCACCTACACTAGAAAGTTATGTTATTCCTGATTCTAAGGATATAGTTAAAAAAGTAAAA
GAGCTATTCTAA

Upstream 100 bases:

>100_bases
TTGATGAAGCAGTAGATTTTGCAAATAATAGTCCATATCCAGAATTAGAGTCAGTATTAGAAGATGTTTATACTGACATT
AAAGAGGAGGTTAGATAACT

Downstream 100 bases:

>100_bases
TCTGAAGGAATATAAAGGGAGATTTTTCCCCTTACTTAATAGGGTGATAATTATGAATAAAATAGGTATAATTGCAAATC
CCGCCTCTGGTAAAGATATA

Product: TPP-dependent acetoin dehydrogenase complex, E1 component, beta subunit

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKKLTYAEAIREAMRTKMSEDDKVLIFGEDVGAFGGCFGVTGDLYKEFGDKRVRDTPISEGAIAGCAVGAAATGLRPIAE
IMFGDFLTVSMDMIVNQAAKMRFMFGGKISLPMVVRLPEGAGVQAAAQHSQSLEAWLTHVPGLKVVYPSTPQDAYGLMVA
AIEDDNPVMFMEHKFLYGMKGEVSDEIKRIPLGVADIKREGKDVTIIATGKMVHESLKAADILSKDGIEVEVIDPRTLYP
LDKETIFNSIKKTNRAVVVTEENKRGAYSGEISSLINEEIFDYLDAPVGRIGALNTPIPFSPTLESYVIPDSKDIVKKVK
ELF

Sequences:

>Translated_323_residues
MKKLTYAEAIREAMRTKMSEDDKVLIFGEDVGAFGGCFGVTGDLYKEFGDKRVRDTPISEGAIAGCAVGAAATGLRPIAE
IMFGDFLTVSMDMIVNQAAKMRFMFGGKISLPMVVRLPEGAGVQAAAQHSQSLEAWLTHVPGLKVVYPSTPQDAYGLMVA
AIEDDNPVMFMEHKFLYGMKGEVSDEIKRIPLGVADIKREGKDVTIIATGKMVHESLKAADILSKDGIEVEVIDPRTLYP
LDKETIFNSIKKTNRAVVVTEENKRGAYSGEISSLINEEIFDYLDAPVGRIGALNTPIPFSPTLESYVIPDSKDIVKKVK
ELF
>Mature_323_residues
MKKLTYAEAIREAMRTKMSEDDKVLIFGEDVGAFGGCFGVTGDLYKEFGDKRVRDTPISEGAIAGCAVGAAATGLRPIAE
IMFGDFLTVSMDMIVNQAAKMRFMFGGKISLPMVVRLPEGAGVQAAAQHSQSLEAWLTHVPGLKVVYPSTPQDAYGLMVA
AIEDDNPVMFMEHKFLYGMKGEVSDEIKRIPLGVADIKREGKDVTIIATGKMVHESLKAADILSKDGIEVEVIDPRTLYP
LDKETIFNSIKKTNRAVVVTEENKRGAYSGEISSLINEEIFDYLDAPVGRIGALNTPIPFSPTLESYVIPDSKDIVKKVK
ELF

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=324, Percent_Identity=42.2839506172839, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=40.1234567901235, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=39.1975308641975, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=39.1975308641975, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI133778974, Length=82, Percent_Identity=45.1219512195122, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=323, Percent_Identity=42.7244582043344, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=40.0621118012422, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=41.8960244648318, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21358145, Length=321, Percent_Identity=42.6791277258567, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24650940, Length=321, Percent_Identity=42.6791277258567, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=41.0493827160494, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=41.0493827160494, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=43.956043956044, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=43.956043956044, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 35277; Mature: 35277

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTYAEAIREAMRTKMSEDDKVLIFGEDVGAFGGCFGVTGDLYKEFGDKRVRDTPISE
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCHHHHHHHCCCCCCCCCCCC
GAIAGCAVGAAATGLRPIAEIMFGDFLTVSMDMIVNQAAKMRFMFGGKISLPMVVRLPEG
CCHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCC
AGVQAAAQHSQSLEAWLTHVPGLKVVYPSTPQDAYGLMVAAIEDDNPVMFMEHKFLYGMK
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCEEECCC
GEVSDEIKRIPLGVADIKREGKDVTIIATGKMVHESLKAADILSKDGIEVEVIDPRTLYP
CCHHHHHHHCCCCHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCEECC
LDKETIFNSIKKTNRAVVVTEENKRGAYSGEISSLINEEIFDYLDAPVGRIGALNTPIPF
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCC
SPTLESYVIPDSKDIVKKVKELF
CCCCCCEECCCCHHHHHHHHHHC
>Mature Secondary Structure
MKKLTYAEAIREAMRTKMSEDDKVLIFGEDVGAFGGCFGVTGDLYKEFGDKRVRDTPISE
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCHHHHHHHCCCCCCCCCCCC
GAIAGCAVGAAATGLRPIAEIMFGDFLTVSMDMIVNQAAKMRFMFGGKISLPMVVRLPEG
CCHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCC
AGVQAAAQHSQSLEAWLTHVPGLKVVYPSTPQDAYGLMVAAIEDDNPVMFMEHKFLYGMK
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCEEECCC
GEVSDEIKRIPLGVADIKREGKDVTIIATGKMVHESLKAADILSKDGIEVEVIDPRTLYP
CCHHHHHHHCCCCHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEECCCEECC
LDKETIFNSIKKTNRAVVVTEENKRGAYSGEISSLINEEIFDYLDAPVGRIGALNTPIPF
CCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCC
SPTLESYVIPDSKDIVKKVKELF
CCCCCCEECCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]