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The map label for this gene is cdr [H]

Identifier: 153937498

GI number: 153937498

Start: 1680170

End: 1681870

Strand: Direct

Name: cdr [H]

Synonym: CLC_1610

Alternate gene names: 153937498

Gene position: 1680170-1681870 (Clockwise)

Preceding gene: 153936768

Following gene: 153935246

Centisome position: 44.68

GC content: 31.1

Gene sequence:

>1701_bases
ATGAGCAAAAAATATTTAATAATAGGAGGAGTTGCTGGTGGTGCATCTACCGCAGCTAGACTTAGAAGACTTAGTGAGGA
AGATCAAATAATAATGTTTGAAAAAGATCCCTATGTATCCTTTTCAAATTGTAGCTTACCTTATCATTTGAGTGGAGTTG
TAGAGGATTCCAATAGTTTAGTACTTATGACTCCAGAACAATTTAAAGCTCAATACAATATAGAGGCTAGAGTAAATAAT
GAAGTTATAACAATTAATAGAGATAAAAAAGAAGTTATAGTTAAAAATACATTAACAGGAGAAAAGTATTCTGAAAATTA
TGATAAATTAATCTTATCTCCAGGAGCAACGCCAATAGTTCCACCAATTAAAGGGATTGAAAATGTAAATGTATTTACAG
TAAGAAATGTAATGGATATAAAAAGATTAAGTGACAAATTAAAAAATAAAAAAGTTGAAAATATATCTGTTATTGGAGGA
GGTTTTATAGGGGTTGAAGTTGCTGAAAATTTAAAAGAAGCAGGAAACGATGTTACTCTAATTGAAGCTATGCCTCATAT
TATGAAACCCTTTGATTATGATATGGCACAAATTTTACACAAAGAATTTTATGATAATGGTGTAAATTTAATTGTAAAAG
ATAAGGTTAGTGCTTTTGAAAAAGACACAGTAGTTTTAGAATCTGGAAGAAAAGTACAGGCTGAGGCTGTAGTTATGGCC
ATAGGTGTAGCTCCAGATACAAGACTTGCAAAGGCGGCAGGATTAGAAATTGGAGAAACAGGAGCTATAAAAGTAGATCA
AAATTATAGAACTAGTGATAAGGATATATATGCAGTAGGAGATGCTATTGAAGTTTATCATGCTCTAGCTAGAAAAACTA
CTAAACTACCTTTAGCAGGACCTGCTCAAAAAGAAGCAAGACAGGTGGCAGATCATATTCATGGAAGAGTTGTTAGGAAT
ACAGGCTTTATAGGAAGTTCAGTAATTAAATGTTTCGATTATAATGCAGCAGCCACAGGACTTAATGAAGAAATGATAGA
AGCATTAAAATTAGACATAAAATATGAGGTGGCTAAGGTGATACCGGGAGATAAGGTAGGATTAATGCCAGATTGTGAGC
CTCTACATTTTAAATTAATTTTCGAAATTCCTACAGGAAAAGTATTAGGGGCACAAGCTATTGGTAAAGGAAATGTAGAT
AAGAGAATAGATATAATTGCTACAGCAATTAAATTTGGAGCTACTGTGGATGATCTAAGAGACTTAGAATTATGCTATGC
ACCACCCTTTGGAACTGCTAAAGATGTAGTAAATTTTGCAGGCTATGTAGCATGTAATTTATTACAGGATGAATTTAGAC
AAGTTAGAGAAAAAGATATAAGAAATATCGTAAAAGAAAAAGCTTTAATTATAGATGTAAGAGAGAAGCATGAATATGAA
TTAAGTCATATTATTGGTGCAAAAAATATACCTCTTAGTGAGTTAAGAGATAGAATAAATGAAATACCTAAAGATGAGCC
TGTGTATTTACACTGTAGAAGTGCTCAAAGAAGTTATAACGCATTAAAGGCTCTTAAAAATTTAGGTTATGAAAATATTT
ATAACGTTTCTGGTGGATTTTTAGGAATTTCTTTTTATGAATACTTTAATGACATAACTACTAAAAGAGAAAAAATTCTT
ACAGATTATAACTTTTTATAA

Upstream 100 bases:

>100_bases
AAAATTATAAAATTAAGTAATCAATAAGTTTTATTTATAAATACAGCCATTATAAGGGGCTTAATACCTTGTACAATATA
TTTTAATGGAGGTATAAATT

Downstream 100 bases:

>100_bases
AATTAGAAATTGAGTAATCTAGCTTATTTAAATAACTATAAGGATTCTATGGTTCAAAAGGAGCTTTTATCTCAATTGAA
CCATAGCAATTCTTAACTAG

Product: pyridine nucleotide-disulphide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNN
EVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIKRLSDKLKNKKVENISVIGG
GFIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVVMA
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDKDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRN
TGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVD
KRIDIIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
LSHIIGAKNIPLSELRDRINEIPKDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKIL
TDYNFL

Sequences:

>Translated_566_residues
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNN
EVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIKRLSDKLKNKKVENISVIGG
GFIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVVMA
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDKDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRN
TGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVD
KRIDIIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
LSHIIGAKNIPLSELRDRINEIPKDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKIL
TDYNFL
>Mature_565_residues
SKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSLVLMTPEQFKAQYNIEARVNNE
VITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIVPPIKGIENVNVFTVRNVMDIKRLSDKLKNKKVENISVIGGG
FIGVEVAENLKEAGNDVTLIEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVVMAI
GVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDKDIYAVGDAIEVYHALARKTTKLPLAGPAQKEARQVADHIHGRVVRNT
GFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKVIPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDK
RIDIIATAIKFGATVDDLRDLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYEL
SHIIGAKNIPLSELRDRINEIPKDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGFLGISFYEYFNDITTKREKILT
DYNFL

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=291, Percent_Identity=29.553264604811, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI65787454, Length=378, Percent_Identity=26.7195767195767, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI226437568, Length=291, Percent_Identity=29.553264604811, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=26.5625, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788892, Length=283, Percent_Identity=26.5017667844523, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789765, Length=296, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786307, Length=329, Percent_Identity=27.355623100304, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=239, Percent_Identity=28.0334728033473, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24639257, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281359715, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281359713, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639250, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18543267, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639252, Length=322, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585130, Length=297, Percent_Identity=20.8754208754209, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 62942; Mature: 62811

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSL
CCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEEEECCCCE
VLMTPEQFKAQYNIEARVNNEVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIV
EEECHHHHCEEEEEEEEECCEEEEEECCCCEEEEEECCCCCHHCCCCCEEEECCCCCCCC
PPIKGIENVNVFTVRNVMDIKRLSDKLKNKKVENISVIGGGFIGVEVAENLKEAGNDVTL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEE
IEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCEEEEECCCEEEEEEEEEE
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDKDIYAVGDAIEVYHALARKTTKLPLAG
EECCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCC
PAQKEARQVADHIHGRVVRNTGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKV
CCHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHCCEEEEEEC
IPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDKRIDIIATAIKFGATVDDLR
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHH
LSHIIGAKNIPLSELRDRINEIPKDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGF
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCE
LGISFYEYFNDITTKREKILTDYNFL
EEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKKYLIIGGVAGGASTAARLRRLSEEDQIIMFEKDPYVSFSNCSLPYHLSGVVEDSNSL
CCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEEEECCCCE
VLMTPEQFKAQYNIEARVNNEVITINRDKKEVIVKNTLTGEKYSENYDKLILSPGATPIV
EEECHHHHCEEEEEEEEECCEEEEEECCCCEEEEEECCCCCHHCCCCCEEEECCCCCCCC
PPIKGIENVNVFTVRNVMDIKRLSDKLKNKKVENISVIGGGFIGVEVAENLKEAGNDVTL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHHHCCCCEEE
IEAMPHIMKPFDYDMAQILHKEFYDNGVNLIVKDKVSAFEKDTVVLESGRKVQAEAVVMA
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCEEEEECCCEEEEEEEEEE
IGVAPDTRLAKAAGLEIGETGAIKVDQNYRTSDKDIYAVGDAIEVYHALARKTTKLPLAG
EECCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCC
PAQKEARQVADHIHGRVVRNTGFIGSSVIKCFDYNAAATGLNEEMIEALKLDIKYEVAKV
CCHHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCHHHCCCCHHHHHHHHHCCEEEEEEC
IPGDKVGLMPDCEPLHFKLIFEIPTGKVLGAQAIGKGNVDKRIDIIATAIKFGATVDDLR
CCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
DLELCYAPPFGTAKDVVNFAGYVACNLLQDEFRQVREKDIRNIVKEKALIIDVREKHEYE
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHH
LSHIIGAKNIPLSELRDRINEIPKDEPVYLHCRSAQRSYNALKALKNLGYENIYNVSGGF
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCE
LGISFYEYFNDITTKREKILTDYNFL
EEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA