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The map label for this gene is vanR [H]

Identifier: 153937109

GI number: 153937109

Start: 1718683

End: 1719375

Strand: Reverse

Name: vanR [H]

Synonym: CLC_1640

Alternate gene names: 153937109

Gene position: 1719375-1718683 (Counterclockwise)

Preceding gene: 153935864

Following gene: 153934672

Centisome position: 45.72

GC content: 29.73

Gene sequence:

>693_bases
ATGATTGAATATAAGGTTTTAATAGTTGATGATGAAGATGAAATAAGAGAAGCTATAGAAATTTATTTAAAAAATGAAGG
TATAACTGTTTTTAAAGCTAAAGATGGAATAGATGCCTTAATGCTTTTAGAAGACCATGATATCCATCTTATTATTATGG
ATATCATGATGCCTAAAATGGATGGCATTAAAGCTACTTTTAAAATTAGAGAAAATAAAAACATTCCTATAATAATGCTT
TCTGCTAAATCTGAGGACACAGATAAGATACTAGGGCTTAATATAGGGGCAGATGATTATGTTACAAAACCCTTTAATAT
GCTAGAGCTAGTAGCTAGGGTTAAATCTCAGCTTAGAAGATATGTCAACTTAGGAAATTATAAAGAAACTGAGGATAAAG
TTGTGGCAGGAGCTCTTATATTAGATAAAAAAACAAAATTAATAATTGTAGATGGAAAAGAAATAAGACTTACCCCTATT
GAATATAGAATACTAGAACTTCTAATGGAAAACAAAGGTAGAGTTTTTTCCATTGAAGAAATATATGAAAAAGCTTGGAA
GGAGCCCTATTACAATGGTGAAAACACCGTAGCTGTGCATATAAGAAGAATAAGAGAAAAAATTGAAATTAACTCTAGAG
AACCAAGATATTTAAAGGTGGTGTGGGGAATTGGTTATAAAATCCAAGAATAA

Upstream 100 bases:

>100_bases
TTATTATTGTAGAAAAAAATAGTAAGGTTAATTTTGATGACCTATTTAGGAGGTGATAAAAATGTTATAATTTATTCCGT
AAAGAAAGGATGGGACAAGT

Downstream 100 bases:

>100_bases
ATTTATTTATATAATATGTTTCATTGTAGGTATATATATGCTGTCTCTTTCATTTTTAACCGGCTATGATTTAATAAAAA
ACAAAAGGTATCTTGTGAAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE

Sequences:

>Translated_230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
>Mature_230_residues
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPI
EYRILELLMENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=35.8407079646018, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=36.1233480176211, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.4561403508772, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.1858407079646, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=32.5892857142857, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=32.4444444444444, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.061135371179, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=30.1310043668122, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=214, Percent_Identity=32.2429906542056, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=28, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=29.7777777777778, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=39.2523364485981, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787487, Length=105, Percent_Identity=34.2857142857143, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788191, Length=112, Percent_Identity=34.8214285714286, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=103, Percent_Identity=34.9514563106796, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26832; Mature: 26832

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHHEEEEECCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCC
DGIKATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPIEYRILELLMENKGRVFSIEE
HHCCCCCCCCCCCEEEEEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC
>Mature Secondary Structure
MIEYKVLIVDDEDEIREAIEIYLKNEGITVFKAKDGIDALMLLEDHDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHHEEEEECCCEEEEEECCCCEEEEEEECCCEEEEEEEECCCCC
DGIKATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGALILDKKTKLIIVDGKEIRLTPIEYRILELLMENKGRVFSIEE
HHCCCCCCCCCCCEEEEEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINSREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]