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The map label for this gene is mutL

Identifier: 153936560

GI number: 153936560

Start: 1843641

End: 1845641

Strand: Reverse

Name: mutL

Synonym: CLC_1741

Alternate gene names: 153936560

Gene position: 1845641-1843641 (Counterclockwise)

Preceding gene: 153936669

Following gene: 153937216

Centisome position: 49.08

GC content: 25.34

Gene sequence:

>2001_bases
ATGAGGAAAATAAATTTATTAGATTTAGAAACTACAAATAAAATAGCTGCAGGAGAAGTTATAGAAAGACCCTTTTCTGT
AGTAAAAGAATTAGTAGAAAATAGTATAGACGCCGGTGCCAAAAATATAACCATAGAAATAGAAGATGGAGGACAAAAGC
TTATAAAAATAATAGATGATGGAGAAGGTATTTATCCTATTGATATAAAAAATGCTTTTCTTCCTCATGCTACAAGTAAA
ATAAATTCTATAGAGGATATATACAAAATAAGTACTATGGGCTTTAGAGGTGAAGCACTAGCTAGCATTTCTTCCGTATC
AAAAACTAAACTTAAAAGTAGAGTTGACTCTTATAATTTTGGAAAAGAAATATATATAGAGGGTGGCAAAATAGAGTACT
TAAAAGATACAGGTTGCAATGTTGGCACTACTATAGAAGTTTCTGATTTATTTTATAATGTACCTGCAAGACTTAAATTT
TTGAAAAGTGCAAGAAGTGATAGTAGTTCTATATCAGATATTGTGAATAGGTTTATATTATCCCATCCAGATATATCTTT
TAATTTAATAAATAAGGGAAAGCAAAGTATAAAGAGTTATGGTACCGGAAATTTAAAGGACTCTATACGATGTGTATACA
ATAAAACAATAAGTGAAAACCTTATAAACTTCGAAAGTCATAAAGATATAATATCTGTATATGGATTTATAGGTAAGCCT
GAAATAAGCCGTAAAAGCAGAACAAATCAAAGTATATTTGTAAACAAGCGATATGTTAAAAGTAAATTTATAACTGCTGC
AGTAGAAAATGCTTTTAAATCCTTTTTAACAGTAAATAGCTATCCTTTCTTTGTAATATTTATAGATATTTTTCCGGAAT
ATATTGATGTAAATGTACATCCTACTAAATCAGAAGTTAAATTTAAAGATGAGAGAGCTATGTTTAAAACTATATTTGAT
GCAGTTCATGAAGCCATAAAAGGAGAATTAAAAGAATCCTTTACAAACTTCTTTAATAAAGAAGATATTAATATATATGA
TTCTGAAAAATCTATAACTGAACCCATAAAACTAGAGAAAGAAGAAGTACAAATACCAATAGATTTAAATAGTAATAATA
AAATTGATATTTTTGGTAATAATATAAATAAACTACCTAACAATACAGAACTTCTTAAAAATATAGGTATTAAAGAAAAA
AATACACTTGAAAATAATAATGATTTCTATACTTCTAAACAAAATGAAATATACTATGCTAATAAAAATGATGAATGTTT
AAATTCATGTAATAAAGATAACTATAGCAAAATAGAAAAGTCATTACAAAAAGATAATAAAAATCCAGATATCTTATATC
TAAATGAGCACAATAGAAATTCTTCACCTATAAATATTAAAGAAAATAAATCTAATAATTTTTATGTAGATATGAAAATA
ATAGGACAGTTTAATAATACATATATATTAATAGAAAAGGATAAAGAACTTTATATAATAGATCAACATGCGGCTCATGA
AAAAGTGTTATTTGAGAAATTCAAATGCGAAATAGAAAAGGGATATGTAATAAGTCAGATTTTATTATCTCCTGTAGTTA
TAGAACTTTCAGAAGATGAATTTAATATATACGAAGAAAACAAGGATATTTTTAAGAATTCAGGTTTTTCAGTGGAAACT
TTTGGAGAATACACTATAAATATAAAAGAAGTACCTTTAATTCTAGGTAAACCCAATGTAGAAAATCTCTTTATGGATAT
ACTTTATAATTTAAAAAATATGAAGTCTAAAGAAACTTCTACAATAAAATATAATGCCATTGCTACACTGGCATGCAAAT
CCGCAGTTAAAGCTAATGACAACTTAAAAGAAGAAGAAATAAAAAAATTAATAGAAGACATGCTTATATTAAATAATCCA
TATACTTGTCCCCATGGAAGACCTACTATGATTAAATTTACATTAAAAGATTTAGAAAAAAAATTTAAAAGAATACAATG
A

Upstream 100 bases:

>100_bases
ATATTAATACATACAAAATCCTATAATTTTTATTGACCTAGTACCACTTATAAGTGGTGCTAACCTATATAATAAAATTA
TAAGCTATGTGGTGATTTAA

Downstream 100 bases:

>100_bases
GGGGGATAAGGAAAAATGATAGATTTATTAATAATTGCAGGTCCTACAGCAGTAGGGAAAACAGATATTTCCATAAAACT
TGCAGAAAAACTAAATGGAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Sequences:

>Translated_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ
>Mature_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILSHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.2424242424242, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI4505911, Length=355, Percent_Identity=28.4507042253521, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI189458898, Length=355, Percent_Identity=28.4507042253521, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=26.453488372093, Blast_Score=131, Evalue=3e-30,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=26.453488372093, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI189458896, Length=348, Percent_Identity=28.735632183908, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=24.0802675585284, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI91992162, Length=464, Percent_Identity=25.8620689655172, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=464, Percent_Identity=25.8620689655172, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=597, Percent_Identity=28.643216080402, Blast_Score=240, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=32.5, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=28.2051282051282, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=36.036036036036, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=30.3116147308782, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=194, Percent_Identity=32.9896907216495, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=759, Percent_Identity=23.1884057971014, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=33.5329341317365, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.2100840336134, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CLOB1 (A7FUK9)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384056.1
- ProteinModelPortal:   A7FUK9
- SMR:   A7FUK9
- STRING:   A7FUK9
- GeneID:   5397570
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1734
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- ProtClustDB:   PRK00095
- BioCyc:   CBOT441770:CLB_1734-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 76326; Mature: 76326

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHH
SHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
CCCCCEEEEHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCEEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEK
EEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC
>Mature Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHH
SHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKP
CCCCCEEEEHHHHHHHHHHCCCCCCHHHHHEECCCHHHHHHHCCCHHHHHHHHHCCCCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCCEEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGIKEKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDILYLNEHNRNSSPINIKENKSNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKCEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEK
EEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA